Na+/H+exchange inhibitor cariporide: effects on respiratory dysfunction after cardiopulmonary bypass

Abstract

The purpose of the present study was to evaluate the potential of the Na⁺/H⁺ exchange inhibitor cariporide to protect the lung from injury after cardiopulmonary bypass (CPB). In a randomized placebo-controlled study, 16 pigs were subjected to CPB for 75 min. Administration of vehicle or cariporide (bolus 180 mg, 40 mg/hour) began 30 min pre-CPB and was continued throughout the protocol. The alveolo-arterial O₂-gradient (AaDO₂), the pulmonary shunt (Qs/Qt), the compliance (Cpl), haemo-dynamic variables and glycerol and water content in lung tissue were measured 10 min before and up to 180 min post-CPB. All animals in the control versus 75% in the cariporide group survived the experiment. At 5 and 60 min post-CPB, the mean AaDO₂ and at 5, 60 and 180 min post-CPB, the mean pulmonary vascular resistance index were higher in the cariporide group (p < 0.05), respectively. More lung water accumulation was found in the cariporide group (p < 0.05). Mean Cpl decreased; the Qs/Qt and glycerol in lung tissue increased without significant intergroup difference. In this model, the inhibitor of the Na⁺/H⁺ antiporter showed no protective effect on lung injury after CPB and might even have harmful effects on pulmonary vascular tone and function.