The reduction or limitation of myocardial infarct size is an appealing approach to improving early survival and late prognosis. Depending on the pathophysiology of myocardial ischaemia and postischaemic resuscitation and the regulation of anaerobic glycolytic energy production, early reperfusion to re-establish blood supply and oxygen availability is the most promising approach to infarct reduction. A good functional result, namely limitation of infarct size, depends on the duration of ischaemia, on the presence of collateral vessels supplying the infracting area and on the removal of a high-grade residual stenosis by angioplasty.
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