Astrobiology is used as an explicit example to illustrate some of the social, political and philosophical problems that have arisen as a result of the current institutionalization of science. The associated funding mechanisms and policies that suffer from overbearing systems of management, bureaucracy and administration and frequently come into direct conflict with the aims and objectives of innovative and bold science initiatives are discussed. The profound changes that are required in science-policy structures to foster and defend both creative freedom and transparency are outlined. Biologically rooted, as well as sociological and political factors are identified that can impede the healthy practice of any multidisciplinary science, and of astrobiology in particular. Solutions and guidelines are offered based on a set of proven operating principles practised by successful multidisciplinary research centres.
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