The aim of this article is to present a novel framework that integrates the strategic dimensions of sustainability and the ISO 21500 standard to evaluate and select subcontractors for megaprojects. ISO 21500 processes were utilized to develop benefits, opportunities, costs, and risks subnets, whereas triple-bottom line sustainability dimensions were used as strategic criteria. Subsequently, the Analytic Network Process was used to examine the proposed framework for the Qatar Rail megaproject. The proposed framework supports organizations dealing with megaprojects to align their subcontractor selection with ISO 21500 and achieve ecological and social objectives alongside the project’s stipulated economic benefits.
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