Abstract
Article: Prenatal Sonographic Detection of Multiple Congenital Anomalies: A Case of Severe Arthrogryposis Multiplex Congenita (AMC)
Authors: Amy Bildner, RDMS, RDCS, RVT, and Daniel Jackson, MD, MS
Category: OB/GYN [OB]
Credit: 1.0 SDMS CME Credit
Objectives: After studying the article entitled “Prenatal Sonographic Detection of Multiple Congenital Anomalies: A Case of Severe Arthrogryposis Multiplex Congenita (AMC),” you will be able to:
Describe the essential sonography findings making it the imaging choice that contributes to diagnosing arthrogryposis multiplex congenita
Differentiate why sonographic diagnoses of contractures occur more in the second trimester versus the first trimester
Explain for this case study the important rationale for including orthopedic, cardiology, neurology, and genetic consultation
What statement best defines arthrogryposis multiplex congenita (AMC)? Believed to be caused by increased fetal movement Biophysical profiles document gross body movement Syndrome defined by the abnormal position of two or more joints Differential diagnosis is narrow and requires a limited diagnostic workup
Which subcategory of AMC etiologies comprise 70% to 80% of cases? Connective tissue defects Intrauterine fetal vascular compromise Maternal disease text Neurologic anomalies
In cases of AMC, what is the most common isolated finding identified during a routine second-trimester sonogram with a prevalence of 1 in 500 live births? Club foot Nuchal edema Renal anomalies Cardiac defects
Although the pathogenesis of AMC is unknown, which fetal neurologic infection insult can cause factors leading to AMC? Fetal cerebral vascular accident Aneuploidy Porencephaly Cytomegalovirus
Which genetic test is not recommended as the first-line genetic testing in obstetrics because of its increased cost and the potential for misinterpretation of results? First-trimester translucency measurement Whole-exome sequencing Genetic amniocentesis Microarray
Which maternal disease has been reported to cause decreased fetal movement due to the transfer of acetylcholinesterase receptor antibodies across the placenta? Myasthenia gravis Muscular dystrophy Mitochondrial disorders Myositis
The differential diagnosis may be due to which extrinsic (oligohydramnios) insult? Zika virus Schizencephaly Bladder outlet obstruction A syndromic condition
In this case study, which extremity was spared severe contractures? Left upper extremity Right upper extremity Left lower extremity Right lower extremity
What response from a lack of fetal motion contributes to contractions or joint fixations? Limb repositioning Growth restriction Collagenic response around joints Mid-muscular ventricular septal defect
What is the purpose of placing an infant in a Pavlick harness? Treat bilateral hip dysplasia Place extremity in a neutral position Add structural integrity to spinal column Adjust plantarflexion
Footnotes