Abstract
Article: Targeted Contrast-Enhanced Ultrasound for Inflammation Detection: A Review of Current Evidence
Authors: Kevin R. Volz, PhD, RVT, Kevin D. Evans, PhD, RT(R)(M)(BD), RDMS, RVS, Christopher D. Kanner, BS, John A. Buford, PhD, PT, Miriam Freimer, MD, and Carolyn M. Sommerich, PhD, CPE
Category: Musculoskeletal [MSK]
Credit: 1.0 SDMS CME Credit
Objectives: After studying the article entitled “Targeted Contrast-Enhanced Ultrasound for Inflammation Detection: A Review of Current Evidence,” you will be able to:
Describe the curvology types that have been suggested to determine CEUS kinetics
Determine the possible applications for CEUS that could facilitate molecular imaging
Explain the inflammatory cascade of enzymes, occurring at the molecular level, which could become binding molecules for ultrasound contrast
The most notable application of contrast-enhanced ultrasound contrast (CEUS), beyond cardiac applications, is which of the following? The diagnosis of testicular tumors The diagnosis of ovarian tumors The imaging of thyroid masses The imaging of renal masses
A 2013 review of the literature found that the sensitivity of detecting liver lesions with CEUS is which of the following? 100% 10% 90% 80%
The inflammatory process is mediated by which of the following cell adhesion molecules? Testosterone Thyroxine ICAM-1 VEGFR-2
Based on the authors’ review of the literature, which of the following inflammatory enzymes combined with a contrast agent was able to burst bubbles? P-selectin + Lipid MB for visualizing the coronary ischemia ICAM-1 + Lipid MB for visualizing coronary vessels VCAM-1, P-selectin + Lipid MB for detecting inflammation VCAM-1 + Lipid MB for detecting the aortic endothelium
Which of the following time intensity curves (TICs) represents the “wash-in and wash-out plateau” of contrast? Type I Type II Type III Type IV
The type III TIC is most generally characterized by which of the following statements? A plateau during the wash-in phase A wash-out phase after two to three minutes A lack of the wash-in phase Bubbles resonating for five minutes in the wash-out phase
Synonyms for describing the TICs associated with CEUS are denoted by which of the following? Contrast uptake curves Perfusion kinetics Time-variant curves Choices A and B
In the Cosgrove et al. study, the CEUS TIC that resulted during patients’ treatment was more sensitive than the computed tomography scan. Which body part was being imaged with CEUS? Liver Breast Kidney Testicle
The authors suggest that CEUS dosing parameters need to be established for which group of patients? Elderly Pediatrics Women over 40 years of age Men who have had recent surgery
Which of the following statements describes a type I TIC? Wash-in phase that reaches a peak and then maintains a plateau Wash-out curve, where a decrease in signal intensity is seen shortly Curve shape that is depressed in wash-in as well as wash-out Curve shape that depicts a continuous signal intensity that builds
Footnotes