Cholelithiasis is a pathology that can be confidently diagnosed by sonographic examination. The following case presents sonographic findings consistent with cholelithiasis in a child being treated with the antibiotic Rocephin. A follow-up preoperative sonographic examination of the gallbladder displayed no evidence of cholelithiasis. This is a classic example of Rocephin-induced “biliary pseudolithiasis.”
8. Palanduz A, Yalcin I, Tonguc E, Guler N, Ones U, Salman N, et al: Sonographic assessment of ceftriaxoneassociated biliary pseudolithiasis in children. J Clin Ultrasound2000;28(4):166–168.
9.
9. Herek O, Sarioglu A, Kocer N, Tiryaki A, Akkemik B: Biliary pseudolithiasis in childhood: a case report. Eur J Pediatr Surg1999;9(5):337–339.
10.
10. Papadopoulou F, Efremidis S, Karyda S, Badouraki M, Karatza E, Panteliadis C, et al: Incidence of ceftriaxoneassociated gallbladder pseudolithiasis. Acta Paediatr1999;88(12):1352–1355.
11.
11. Lorberboym M, Machado M, Glajchen N, Pertsemlidis D: Transient false-positive hepatobiliary scan associated with ceftriaxone therapy. Clin Nucl Med1996;21(1):4–7.
12.
12. Fekety FR: Safety of parenteral third-generation cephalosporins. Am J Med1990;88(4A):38S–44S.
13.
13. Shiffman ML, Keith FB, Moore EW: Pathogenesis of ceftriaxone-associated biliary sludge: in vitro studies of calcium-ceftriaxone binding and solubility. Gastroenterology1990;99(6):1772–1778.
14.
14. Park HZ, Lee SP, Schy AL: Ceftriaxone-associated gallbladder sludge: identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Gastroenterology1991;100(6):1665–1670.
15.
15. Tokumine F, Sunagawa T, Shiohira Y, Nakamoto T, Miyazato F, Muto Y: Drug-associated cholelithiasis: a case of Sulindac stone formation and the incorporation of Sulindac metabolites into the gallstones. AmJ Gastroenterol1999;94(8):2285–2288.
16.
16. Spes CH, Angermann CE, Beyer RW, Schreiner J, Lehnert P, Kemkes BM, et al: Increased incidence of cholelithiasis in heart transplant recipients receiving cyclosporine therapy. J Heart Transplant1990;9(4):404–407.
17.
17. Weinstein S, Lipsitz EC, Addonizio L, Stolar CJ: Cholelithiasis in pediatric cardiac transplant patients on cyclosporine. J Pediatr Surg1995;30(1):61–64.
18.
18. Alberu J, Alberu J, Gatica M, Cachafeiro-Vilar M, Robles-Diaz G, Bezaury P, et al: Asymptomatic gallstones and duration of cyclosporine use in kidney transplant recipients. Rev Invest Clin2001;53(5):396–400.
