Efficacy and Toxicity of Amphotericin B Liposomal and Lipid Formulations

Abstract

Objective:

To review the efficacy and toxicity of amphotericin B liposomal and various lipid formulations with conventional amphotericin B desoxycholate.

Data Sources:

Pertinent literature was identified via a MEDLINE search.

Study Selection:

English-language clinical trials.

Conclusions:

The incorporation of amphotericin B into liposomes or lipid formulations appears to be a novel method of administering amphotericin B for the treatment of serious systemic fungal infections for patients who have either failed therapy with, or are intolerant to, conventional amphotericin B desoxycholate.