Issues in Contemporary Drug Delivery

Gibaldi M Perrier D , eds. Pharmacokinetics. 2nd ed. New York: Marcel Dekker, 1982:iii.

Silber BM Bialer M Yacobi A . In: Robinson JR Lee VHL , eds. Controlled drug delivery. 2nd ed. New York: Marcel Dekker, 1987: 213–51.

Colbum WA . Pharmacokinetics/pharmacodynamics: Measures, models and manipulations. In: Young J Ingalls VW Flankins R , eds. Simulations at the frontiers of science. San Diego: Society of Computer Simulation, 1986:7–11.

Colburn WA . Perspectives in pharmacokinetics. J Pharmacokinet Biopharm 1987; 15: 545–52.

Norman TR Burrows GD . Plasma concentrations of benzodiazepines—a review of clinical findings and implications. Prog Neuropsychopharmacol Biol Psychiatr 1984; 8: 115–26.

Friedel RD . Relationships of plasma levels of benzodiazepines and clinical response: A critical review. In: Usdin E , ed. Clinical pharmacology in psychiatry. New York: Elsevier, 1981:81–94.

Bellantuono C Reggi V Tognoni G Garattini S . Benzodiazepines: Clinical pharmacology and therapeutic use. Drugs 1980; 19: 195–219.

Itil TM Itil KZ . The significance of pharmacodynamic measurements in the assessment of bioavailability and bioequivalence of psychotropic drugs using CEEG and dynamic brain mapping. J Clin Psychiatr 1986; 47: 20–7.

Wagner JG . Kinetics of pharmacologic response. I: Proposed relationships between response and drug concentration in the intact animal and man. J Theor Biol 1968; 30: 173–201.

Segre G . Kinetics and interaction between drugs and biological systems. Il Farmaco Sci Ed 1968; 23: 907–18.

Hull CJ Beem HBHV McLeod K Sibbald A Watson JM . A pharmacodynamic model for pancuronium. Br J Anaesth 1978; 50: 1113–23.

Sheiner LB Stanski DR Vozeh S Miller RD Ham J . Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979; 25: 358–70.

Colburn WA Jack ML . Relationships among CSF drug concentrations, receptors, binding characteristics, and pharmacokinetic and pharmacodynamic properties of selected 1,4-substituted benzodiazepines. Clin Pharmacokinet 1987; 13: 179–90.

Colburn WA . Simultaneous pharmacokinetic and pharmacodynamic modeling. J Pharmacokinet Biopharm 1981; 9: 367–88.

Colburn WA Brazzell RK . Pharmacokinetics as an aid to understanding drug effects. Adv Pain Res Ther 1986; 8: 427–39.

Unadkat JD Bartha F Sheiner LB . Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther 1986; 40: 86–93.

Fuseau E Sheiner LB . Simultaneous modeling of pharmacokinetics and pharmacodynamics with a nonparametric dynamic model. Clin Pharmacol Ther 1984; 35: 733–41.

Wagner JG . Pharmacokinetics: Past developments, present issues, future challenges. In: Welling PG Tse FLS , eds. Pharmacokinetics; New York: Marcel Dekker, 1988:3–26.

Sikic BI Collins JM Mimnaugh EG Gram TC . Improved therapeutic index of bleomycin when administered by continuous infusion in mice. Cancer Treat Rep 1978; 62: 2011–7.

Fara J Urquhart J . The value of infusion and injection regimens in assessing efficacy and toxicity of drugs. Trends Pharmacol Sci 1984; 5: 21–5.

Urquhart J . Ophthalmic drug delivery systems. In: Robinson JR , ed. Pharmaceutical dosage forms. Washington, DC: Academy of Pharmaceutical Sciences, 1980:105–15.

Shaw J Urquhart J . The injection-infusion comparison (IIC) protocol. Trends Pharmacol Sci 1980; 1: 208–10.

Nau H Merker JH Brendel K Gansau C Hauser I Wittfoht W . Disposition, embryotoxicity and teratogenicity of valproic acid in the mouse as related to man. In: Levy RH Eichelbaum M Pitlick WH Meijer J , eds. Metabolism of antiepileptic drugs. New York: Raven Press, 1984:85–96.

Nau H Spielmann H . Embryotoxicity testing of valproic acid. Lancet 1983; 1: 763–5.

Nau H Ziever R Spielmann H Neubert D Gansau C . A new model for embryotoxicity testing: Teratogenicity and pharmacokinetics of valproic acid following constant rate administration in the mouse using human therapeutic drug and metabolite concentrations. Life Sci 1981; 29: 2803–14.

Riviere JE Carver MP Coppoc GL Carlton WW Lanctz GC Shy-Modjeska J . Pharmacokinetics and comparative nephrotoxicity of fixed-dose versus fixed-internal reduction of gentamicin dosage in subtotal nephrectomized dogs. Toxicol Appl Pharmacol 1984; 75: 496–509.

Urquhart J Nichols K . Pharmacodynamics research in new drug research and development. Proceedings of a Conference on Drug Delivery Systems. Eugene, OR: Aster Publishing, 1985:13–6.

Boxenbaum H . Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin. J Pharmacokinet Biopharm 1980; 8: 165–76.

Boxenbaum H . Interspecies scaling, allometry, physiological time and the ground plan of pharmacokinetics. J Pharmacokinet Biopharm 1982; 10: 201–27.

Kleinbloesem CH . Nifedipine: Clinical pharmacodynamics and haemodynamic effects (dissertation). Leiden, The Netherlands: Rijksuniversiteit te Leiden, 1985:71–9.

McLeod SM Gilles HG Patzalek-Thierson JJ Sellers EM . Diazepam action and plasma concentrations following ethanol ingestion. Eur J Clin Pharmacol 1977; 11: 345–9.

Physicians' desk reference. 39th ed. Oradell, NJ: Medical Economics, 1985:843–4, 1606–8.

Langmuir I . The adsorption of gasses on plane surfaces of glass, mica and platinum. J Am Chem Soc 1918; 40: 1361–4.

Clark AJ . General pharmacology. In: Heffter's handbuch d-experimantic pharmacologie erg. Berlin: Rand & Springer, 1937:15–27.

Ariens EJ . Affinity and intrinsic activity in the theory of competitive inhibition. Arch Int Pharmacodyn Ther 1954; 99: 32–49.

Stephenson RP . A modification of receptor theory. Br J Pharmacol 1956; 11: 371–93.

Furchgott RF . The classification of adrenoreceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Blaschko C Muscholl HC , eds. Handbook of experimental pharmacology. Vol. 33. Catecholamines. Berlin: Springer-Verlag, 1972:283–335.

Levy G . Kinetics of pharmacologic effects. Clin Pharmacol Ther 1966; 7: 362–72.

Levy G . Relationship between elimination rate of drugs and rate of decline of their pharmacologic effects. J Pharm Sci 1964; 53: 342–3.

Holford NHG Sheiner LB . Kinetics of pharmacological response. Pharmacol Ther 1982; 16: 143–66.

Eichelbaum M Brikel P Grube E Gutgemann U Somogyi A . Effects of verapamil on P-R intervals in relation to verapamil plasma levels following single IV and oral administration and during chronic treatment. Klin Wochenschr 1980; 58: 919–25.

Holford NHG Coates PE Guentert TW Riegelman S Sheiner LB . The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: Concentration-effect relationships. Br J Clin Pharmacol 1981; 11: 187–95.

Whiting B Holford NHG Sheiner LB . Quantitative analysis of the disopyramide concentration-effect relationship. Br J Clin Pharmacol 1980; 9: 67–75.

Kramer WG Kolibash AJ Lewis RP Bathala MS Visconti JA Reuning RH . Pharmacokinetics of digoxin: Relationship between intensity and predicted compartmental drug levels in man. J Pharmacokinet Biopharm 1979; 1; 47–61.

Esler M Zweifer A Randall O DeQuattro V . Pathophysiologic and pharmacokinetic determinants of the antihypertensive response to propranolol. Clin Pharmacol Ther 1977; 22: 299–308.

Kelman AW Whiting B . Modeling of drug response in individual subjects. J Pharmacokinet Biopharm 1980; 8: 115–30.

Hill AV . The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 1910; 40: iv–vii.

Holford NHG Sheiner LB . Pharmacokinetic and pharmacodynamic modeling in vivo. Crit Rev Bioeng 1981; 5: 273–322.

West JR Kendall MJ Mitchard M . A comparison of slow release with conventional oxpranolol: Plasma concentration and clinical effects. Br J Clin Pharmacol 1976; 3: 439–13.

McAnish J Baber NS Smith R Young J . Pharmacokinetic and pharmacodynamic studies with long-acting propranolol. Br J Clin Pharmacol 1978; 6: 115–21.

Falliers CJ . Pharmacodynamic and spirometric responses to sustained-release theophylline. N Engl J Med 1979; 17: 125–30.

Brunner L Imhof P Jack D . Relationship between plasma concentrations and cardiovascular effects of oral oxpranolol in man. Eur J Clin Pharmacol 1975; 8: 3–9.

Ishizaki T Hirayama J Tawara K Nakaya H Sato M Sato K . Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: A study using sotalol as a model drug. J Pharmacol Exp Ther 1980; 212: 173–81.

Hager WD Pieniaszek HJ Perrier D Mayersohn M Goldberger V . Assessment of beta blockade with propranolol. Clin Pharmacol Ther 1981; 30: 283–90.

McDevitt DG Shand DG . Plasma concentrations and the time course of beta blockade due to propranolol. Clin Pharmacol Ther 1975; 18: 708–13.

Zacest R Koch-Weser J . Relation of propranolol plasma level to beta blockade during oral therapy. Pharmacology 1972; 7: 178–84.

Singh BN Williams FM Whitlock RM Collett J Chew C . Plasma timolol levels and systolic time intervals. Clin Pharmacol Ther 1980; 27: 159–66.

Winkle RA Meffin PJ Fitzgerald JW Harrison DC . Clinical efficacy and pharmacokinetics of a new orally effective antiarrhythmic, tocainide. Circulation 1976; 54: 884–90.

Ablad B Borg KO Johnson G Regardh CG Solvell SJ . Combined pharmacokinetic and pharmacodynamic studies on alprenolol and 4-hydroxyalprenolol in man. Life Sci 1974; 14: 693–704.

Galeazzi RL Benet LZ Sheiner LB . Relationship between pharmacokinetics and pharmacodynamics of procainamide. Clin Pharmacol Ther 1976; 20: 278–89.

Meffin PJ Winkle RA Blaschke TF Fitzgerald J Harrison DC . Response to optimization of drug dosage: Antiarrhythmic studies with tocainide. Clin Pharmacol Ther 1977; 22: 42–57.

Meinertz T Kasper W Kersting F Just H Bechtold H Janchen E . Lorcainide. II. Plasma concentration-effect relationship. Clin Pharmacol Ther 1979; 26: 196–204.

Metinko PA Ogilvie RI . Rational intravenous doses of theophylline. N Engl J Med 1973; 259: 600–3.

Hendeles L Iafrate RP Weinberger M . A clinical and pharmacokinetic basis for the selection and use of slow release theophylline products. Clin Pharmacol Ther 1984; 9: 95–135.

Nagashima R O'Reilly RA Levy G . Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin. Clin Pharmacol Ther 1969; 10: 22–35.

Routledge PA Chapman PH Davies DM Rawlins MD . Pharmacokinetics and pharmacodynamics of warfarin at steady state. Br J Clin Pharmacol 1979; 8: 243–7.

Whitfield LR Levy G . Relationship between plasma concentration and anticoagulant effect of heparin in plasma of normal subjects: Magnitude and predictability of interindividual differences. Clin Pharmacol Ther 1980; 28: 509–16.