Antiviral Drugs: Pharmacokinetics,Adverse Effects,and Therapeutic Use

Gordon M Buchanan RL Crenshaw RR . A review of approaches to viral chemotherapy. J Med 1981; 12: 289–382.

Davis DJ . Measurements of the prevalence of viral infections. J Infect Dis 1976; 133: A3–5.

Robins RK . Synthetic antiviral agents. Chem Eng News 1986; 64: 28–40.

Miller WH Miller RL . Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem 1980; 255: 7204–7.

Collins P Appleyard G Oliver NM . Sensitivity of herpes virus isolates from acyclovir clinical trials. Am J Med 1982; 73: 380–2.

Whitley RJ Blum MR Barton N . Pharmacokinetics of acyclovir in humans following intravenous administration. Am J Med 1982; 73: 165–71.

de Miranda P Whitley RJ Blum MR . Acyclovir kinetics after intravenous infusion. Clin Pharmacol Ther 1979; 26: 718–28.

Fiddian AP Brigden D Yeo JM Hickmott EA . Acyclovir: An update of the clinical applications of this antiherpes agent. Antiviral Res 1984; 4: 99–117.

Laskin OL Longstreth JA Saral R . Pharmacokinetics and tolerance of acyclovir, a new anti-herpesvirus agent, in humans. Antimicrob Agents Chemother 1982; 21: 393–8.

Laskin OL . Acyclovir: Pharmacology and clinical experience. Arch Intern Med 1984; 144: 1241–6.

Van Dyke RB Connor JD Wyborny C . Pharmacokinetics of orally administered acyclovir in patients with herpes progenitalis. Am J Med 1982; 73: 172–5.

Straus SE Smith HA Brickman C . Acyclovir for chronic mucocutaneous herpes simplex virus infection in immunosuppressed patients. Ann Intern Med 1982; 96: 270–7.

Bryson YJ Dillon M Lovett M . Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. N Engl J Med 1983; 308: 916–21.

Laskin OL Longstreth JA Whelton A . Effect of renal failure on the pharmacokinetics of acyclovir. Am J Med 1982; 73: 197–201.

Krasny HC Liao SHT de Miranda P . Influence of hemodialysis on acyclovir pharmacokinetics in patients with chronic renal failure. Am J Med 1982; 73: 202–4.

Yeager AS . Use of acyclovir in premature and term neonates. Am J Med 1982; 73: 205–9.

Hintz M Connor JD Spector SA . Neonatal acyclovir pharmacokinetics in patients with herpesvirus infection. Am J Med 1982; 73: 210–4.

Keeney RE Kirk LE Brigden D . Acyclovir tolerance in humans. Am J Med 1982; 73: 176–81.

Brigden D Rosling AE Woods NC . Renal function after acyclovir intravenous injection. Am J Med 1982; 73: 182–5.

Balfour HH Jr . Acyclovir. In: Peterson PK Verhoef J , eds. Antimicrobial agents annual/1. New York: Elsevier, 1986: 322–34.

Bean B Aeppli D . Adverse effects of high-dose intravenous acyclovir in ambulatory patients with acute herpes zoster. J Infect Dis 1985; 151: 362–5.

Lisby SM Nahata MC Powell DA . Nausea and vomiting possibly associated with intravenous acyclovir. Drug Intell Clin Pharm 1986; 20: 371–3.

Wade JC Meyers JD . Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med 1983; 98: 921–5.

Skoldenberg B Forsgren M Alestig K . Acyclovir versus vidarabine in herpes simplex encephalitis. Lancet 1984; 2: 707–11.

Whitley RJ Alford C Hess F . Vidarabine: A preliminary review of its pharmacological properties and therapeutic use. Drugs 1980; 20: 267–82.

Poirier RH Kinkel AW Ellison AC . Intraocular penetration of topical 3% adenine arabinoside. In: Pavan-Langston D Buchanan RA Alford CA , eds. Adenine arabinoside: An antiviral agent. New York: Raven Press, 1975: 307–12.

Arnoff GR Szwed JJ Nelson RL . Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure. Antimicrob Agents Chemother 1980; 18: 212–4.

Ross AH Julia A Balakrishnan C . Toxicity of adenine arabinoside in humans. J Infect Dis 1976; 133 (suppl): 192–8.

Sacks SL Smith JL Pollard RB . Toxicity of vidarabine (letter). JAMA 1979; 241: 28–9.

Van Etta L Brown J Mastiri A . Fatal vidarabine toxicity in a patient with normal renal function. JAMA 1981; 246: 1703–5.

Whitley RJ Nahmias AJ Soong S . Vidarabine therapy of neonatal herpes simplex virus infection. Pediatrics 1980; 66: 495–501.

Kaufman HE . Herpetic keratitis: Proctor lecture. Invest Ophthalmol Vis Sci 1978; 17: 941–57.

Pavan-Langston DR . Ocular viral diagnosis. In: Galasso GJ Merigan TC Buchanen RA , eds. Antiviral agents and viral diseases of man. 2nd ed. New York: Raven Press, 1984: 207–46.

Nahata MC . Clinical use of antiviral drugs. Drug Intell Clin Pharm 1987; 21: 399–405.

Genital herpes infection—United States, 1966–1984. MMWR 1986; 35: 402–4.

Nilsen AE Aasen T Halsos AM . Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes. Lancet 1982; 2: 571–3.

Mertz GJ Critchlow CW Benedetti J . Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. JAMA 1984; 252: 1147–51.

Bryson Y Dillon M Lovett M Bernstein D Garratty E Sayre J . Treatment of first episode genital HSV with oral acyclovir: Long term follow-up of recurrences. Scand J Infect Dis [Suppl] 1985: 47: 70–5.

Corey L Fife KH Benedetti JK . Intravenous acyclovir for the treatment of primary genital herpes. Ann Intern Med 1983; 98: 914–21.

Corey L Nahmias AJ Guinan ME . A trial of topical acyclovir in genital herpes simplex virus infections. N Engl J Med 1982; 306: 1313–9.

Reichman RC Badger GJ Mertz GJ Corey L . Treatment of recurrent genital herpes simplex infections with oral acyclovir: A controlled trial. JAMA 1984; 251: 2103–7.

Straus SE Takiff HE Seidlin M . Suppression of frequently recurring genital herpes: A placebo-controlled double-blind trial of oral acyclovir. N Engl J Med 1984; 310: 1545–50.

Douglas JM Critchlow C Benedetti J . A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984; 310: 1551–6.

Mindel A Faherty A Hindley D . Prophylactic oral acyclovir in recurrent genital herpes. Lancet 1984; 2: 57–9.

Shepp DH Newton BA Dandliker PS Flourney N Meyers JD . Oral acyclovir therapy for mucocutaneous herpes simplex virus infections in immunocompromised marrow transplant patients. Ann Intern Med 1985; 102: 783–5.

Whitley RJ Alford CA Hirsch MS . Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 1986; 314: 144–9.

Shepp DH Dandliker PS Meyers JD . Treatment of varicella-zoster virus infection in severely immunocompromised patients. N Engl J Med 1986; 314: 208–12.

Collaborative DHPG treatment study group. Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl) guanine in patients with AIDS and other immunodeficiencies. N Engl J Med 1986; 314: 801–5.

Davies WE Grunert RR Haff RF . Antiviral activity of 1-adamantanamine (amantadine). Science 1964; 144: 862–3.

Aoki FY Sitar DS . Amantadine kinetics in healthy elderly men: Implications for influenza prevention. Clin Pharmacol Ther 1985; 37: 137–44.

Bryson YJ Monahan C Pollack M . A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis. J Infect Dis 1980; 142: 543–7.

Hayden FG Gwaltney JM Van de Castle RL . Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother 1981; 19: 226–33.

Burlington DB Meiklejohn G Mostow SR . Anti-influenza A virus activity of amantadine hydrochloride and rimantadine hydrochloride in ferret tracheal ciliated epithelium. Antimicrob Agents Chemother 1982; 21: 794–9.

Nahata MC Brady MT . Serum concentrations and safety of rimantadine in pediatric patients. Eur J Clin Pharmacol 1986; 30: 719–22.

Hayden FG Hoffman HE Spyker DA . Differences in amantadine hydrochloride and rimantadine hydrochloride side effects relate to differences in pharmacokinetics. Antimicrob Agents Chemother 1983; 23: 458–64.

Prevention and control of influenza. MMWR 1985; 24: 261–8, 273–4.

Younkin SW Betts RF Roth FK . Reduction in fever and symptoms in young adults with influenza A/Brazil/78 N₁N₁ infection after treatment with aspirin or amantadine. Antimicrob Agents Chemother 1983; 23: 577–82.

Bryson YJ . The use of amantadine in children for prophylaxis and treatment of influenza A infections. Pediatr Infect Dis 1982; 1: 44–6.

Dolin R Reichman RC Madore HP . A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. N Engl J Med 1982; 307: 580–4.

Hayden FG Zlydnikov DM Iljenko VI . Comparative therapeutic effect of aerosolized and oral rimantadine HCl in experimental human influenza A virus infection. Antiviral Res 1982; 2: 147–53.

Hruska JF Bernstein JM Douglas RG Jr . Effects of ribavirin on respiratory syncytial virus in vitro. Antimicrob Agents Chemother 1980; 17: 770–5.

Hall CB . Ribavirin and respiratory syncytial virus. Am J Dis Child 1986; 140: 331–2.

Nahata MC Johnson JA Powell DA . Management of bronchiolitis. Clin Pharm 1985; 4: 297–303.

Stokes GM Milner GM Hodges DIGC . Lung function abnormalities after acute bronchiolitis. J Pediatr 1981; 93: 871–4.

Hall CB McBride JT Walsh EE . Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. A randomized double-blind study. N Engl J Med 1983; 308: 1443–7.

Taber LH Knight V Gillser BE . Ribavirin aerosol treatment of bronchiolitis due to respiratory syncytial virus infection in infants. Pediatrics 1983; 72: 613–8.

Douglas RG Jr . The common cold: Relief at last? N Engl J Med 1986; 314: 114–5.

Hayden FG Albrecht JK Kaiser DL . Prevention of natural colds by contact prophylaxis with intranasal alpha₂-interferon. N Engl J Med 1986; 314: 71–5.

Douglas RM Moore BW Miles HB . Prophylactic efficacy of intranasal alpha₂-interferon against rhinovirus infections in the family setting. N Engl J Med 1986; 314: 65–70.

Yarchoan R Weinhold KJ Lyerly HK . Administration of 3′azido-3′-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet 1986; 1: 575–80.