Pattern of Lisdexamfetamine Ingestions Reported to Texas Poison Centers

Abstract

Background:

Little information exists on lisdexamfetamine ingestions reported to poison centers.

Objective:

To describe the pattern of lisdexamfetamine ingestions reported during the first year of their approved use to Texas poison centers.

Methods:

The distribution of total cases of lisdexamfetamine ingestions with and without coingestants reported to Texas poison centers from July 2007–June 2008 was determined for the following selected variables: drug formulation, reported total dose ingested, patient sex and age, exposure site, and circumstances of the exposure.

Results:

Of 187 total ingestions, the total dose ingested was reported for 59% (mean 221.4 mg; range 5–3,080). Fifty-eight percent of the patients were male and 38% were aged 6–12 years. Thirty-eight percent of the ingestions occurred as a result of therapeutic error, 26% were due to general unintentional reasons, and 12% were suspected attempted suicide; 11% of the patients called the poison center due to an adverse reaction to lisdexamfetamine. Of the 133 (71%) cases without coingestants, 53% were managed on site (ie, not a healthcare facility) and 79% resulted in or were expected to result in, at most, minor effects or minimal toxicity. The most frequently reported adverse clinical effects among cases without coingestants were tachycardia (14%), agitation (14%), vomiting (6%), and nausea (5%).

Conclusions:

The majority of lisdexamfetamine ingestions reported to Texas poison centers did not involve coingestants. Of those without coingestants, most were managed on site and did not result in serious medical outcomes.