Contributions of Histochemistry to the Development of the Proteolytic Enzyme Detection System in Diagnostic Medicine 1 2

Aiach M , Schreiber N , Nassas C , Michaud A , Leon M , Leclerc M : An automated amidolytic assay for testing factor X activity. Thromb Res 21: 317, 1981

Andreasen T : Automated two-stage assay for determination of antithrombin III with a centrifugal analyzer. Haemostasis 9: 65, 1980

Aoki N , Yamanaka T : The α₂-plasmin inhibitor levels in liver diseases. Clin Chim Acta 84: 99, 1978

Barrett AJ (Ed): Proteinases in Mammalian Cells and Tissues. Elsevier/North-Holland, Amsterdam, 1977

Bigbee WL , Jensen RH : Characterization of plasminogen activator in human cervical cells. Biochim Biophys Acta 540: 285, 1978

Bishop RC , Hudson PM , Mitchell GA , Pochron SP : Use of fluorogenic substrates for the assay of antithrombin III and heparin. Ann NY Acad Sci 370: 720, 1981

Burchiel KJ , Schmer G : A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms. J Neurosurg 54: 12, 1981

Burstone MS : Enzyme Histochemistry and its Application in the Study of Neoplasms. Academic Press, New York, 1962

Chance RE : Amino acid sequences of proinsulins and intermediates. J Am Diabetes Assoc 21: 461, 1972

Choo IHF , Didisheim P , Doerge ML , Johnson ML , Bach ML , Melchert LM , Johnson WJ , Taylor WF : Evaluation of a heparin assay method using a fluorogenic synthetic peptide substrate for thrombin. Thromb Res 25: 115, 1982

Davie EW , Fujikawa K , Kurachi K , Kisiel W : The role of serine proteases in the blood coagulation cascade. In Advances in Enzymology and Related Areas of Molecular Biology, vol. 48. Edited by Meister A John Wiley & Sons, New York, 1979, p 277–318

Erlanger BF , Kokowski N , Cohen W : The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys 95: 271, 1961

Folk JE , Burstone MS : Chromogenic leucyl substrates for aminopeptidase and papain. Proc Soc Exp Biol 89: 473, 1955

Garrett JR , Smith RE , Kidd A , Kyriacou K , Grabske RJ : Kallikrein-like activity in salivary glands. J Histochem Cytochem 30: 573, 1982

Glenner GG , Cohen LA : Histochemical demonstration of a species-specific trypsin-like enzyme in mast cells. Nature 185: 846, 1960

Goldberg DM , Werner M (Eds): Progress in Clinical Enzymology. Masson, New York, 1980, p 1–290

Goldberg DM , Wilkinson JH (Eds): Enzymes in Health and Disease. Karger, Basel, 1978, p 1–237

Gomori G : Chromogenic substrates for aminopeptidase. Proc Soc Exp Biol Med 87: 559, 1954

Gossrau R : Cytochemical localization of enteropeptidase (enterokinase, 3.4.21.9). In Program of U.S.-Japan Histochemistry and Cytochemistry Congress: 1982, Abstract 100

Green MN , Tsou KC , Bressler R , Seligman AM : The colorimetric determination of leucine aminopeptidase activity with L-leucyl-β-naphthylamide hydrochloride. Arch Biochem 57: 458, 1955

Greenstein JP : Some biochemical characteristics of morphologically separable cancers. Cancer Res 16: 641, 1956

Grunbaum BW : The Grunbaum system for electrophoresis—standardization of equipment. In Handbook for Forensic Individualization of Human Blood and Bloodstains. Sartorius G, Hayward, CA, 1981, ch 3, p 7–50

Hama T , Nagatsu T , Kobayashi S , Azuma S , Miyachi T , Kumagai Y , Kato T : Changes in the form of dipeptidyl-aminopeptidase IV in urine from patients with renal disease. Clin Chim Acta 113: 217, 1981

Hopsu-Havu VK , Glenner GG : A new dipeptide naphthylamidase hydrolyzing acyl glycyl-prolyl-β-naphthylamide. Histochemie 7: 197, 1966

Huseby RM , Clavin SA , Smith RE , Hull RN , Smithwick E Jr : Studies on tissue culture plasminogen activator II. The detection and assay of urokinase and plasminogen activator from LLLC-PK₁₁ cultures (porcine) by the synthetic substrate NΑ-benzylox-ycarbonyl-glycyl-glycyl-arginyl-4-methoxy-2-naphthy-lamide. Thromb Res 10: 679, 1977

Huseby RM , Smith RE : Synthetic oligopeptide substrates, their diagnostic application in blood coagulation, fibrinolysis, and other pathologic states. In Seminars in Thrombosis and Hemostasis, vol. 6, no. 3. Edited by Mammen EF Thieme-Stratton Inc., New York, 1980, p 173–314

Ibsen KH , Fishman WH : Developmental gene expression in cancer. Biochim Biophys Acta 560: 243, 1979

Kalil J , Angles-Cano E , Crevat D , Sultan Y , Fellows M : Production of monoclonal antibodies against HLA-DR antigens and the human plasma plasminogen-activator. In Monoclonal Antibodies Against Molecules. Proceedings of 28th Colloquium on Protides of Biological Fluids. Edited by Peters H , Pergamon, New York, 1980, p 587–593

Kato H , Adachi N , Ohno Y , Iwanaga S , Takada K , Sakakibara S : New fluorogenic peptide substrates for plasmin. J Biochem 88: 183, 1980

Knox WE : Enzyme Patterns in Fetal, Adult, and Neoplastic Rat Tissues. Karger, Basel, 1976

Lojda Z , Kulich J : The usefulness of the analytical electrofocusing in a thin-layer Polyacrylamide gel (PAG) in the histochemistry of enzymes cleaving peptide bonds. Histochemistry 73: 311–319, 1981

Lundgren E , Roos G : Plasma membrane-bound and lysosomal isozymes of amino acid naphthylamidase. Biochim Biophys Acta 358: 208, 1974

McEntee MP , Jesty J , Hultin MB : Effect of oral contraceptives on antithrombin III. Thromb Res 24: 13, 1981

McRae BJ , Kurachi K , Heimark RL , Fujikawa K , Davie EW , Powers JC : Mapping the active sites of bovine thrombin, Factor IX_a, Factor X_a, Factor XI_a, Factor XII_a, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates. Biochemistry 20: 7196, 1981

Melnick PJ : Cytoenzymology and isozymes of cultured cells. Prog Histochem Cytochem 2: 1, 1971

Millan JL , Beckman G , Jeppsson A , Stigbrand T : Genetic variants of placental alkaline phosphatase as detected by a monoclonal antibody. Hum Genet 60: 145, 1982

Mitchell GA , Hudson PM , Huseby RM , Pochron SP , Gargiulo RJ : Fluorescent substrate assay for antithrombin III. Thromb Res 12: 219, 1978

Mitchell GA , Gargiulo RJ , Huseby RM , Lawson DE , Pochron SP , Sehaunes JA : Assay for plasma heparin using a synthetic peptide substrate for thrombin: introduction of the fluorophore aminoisophthalic acid, dimethyl ester. Thromb Res 13: 47, 1978

Monnier L , Follea G , Mirouze J : Antithrombin III deficiency in diabetes mellitus: influence on vascular degenerative complications. Horm Metab Res 10: 470, 1978

Mort JS , Leduc M : A simple, economical method for staining gels for cathepsin B-like activity. Anal Biochem 119: 148, 1982

Nachlas MM , Monis N , Rosenblatt D , Seligman AM : Improvement of the histochemical localization of leucine aminopeptidase with a new substrate, L-leucyl-4-methoxy-2-naphthylamide. J Biophys Biochem Cytol 7: 261, 1960

Nachlas MM , Plapinger RE , Seligman AM : Role of some structural features of substrates on trypsin activity. Arch Biochem Biophys 108: 266, 1964

Niklasson O , Svanberg L , Thorell J , Lecander I , Astedt B : Urokinase-like plasminogen activator as a marker of endometrial neoplasia. Cancer 48: 1484, 1981

Ohno Y , Kato H , Morita T , Iwanaga S , Takada K , Sakakibara S , Stenflo J : A new fluorogenic peptide substrate for vitamin K-dependent blood coagulation factor, bovine protein c. J Biochem 90: 1387, 1981

Panicucci F , Sagripanti A , Conte B , Pinori E , Vispi M , Lecchini L : Antithrombin III, heparin cofactor and antifactor Xa in relation to age, sex, and pathological condition. Haemostasis 9: 297, 1980

Pearson KW , Smith RE , Mitchell AR , Bisseil ER : Automated enzyme assays by use of a centrifugal analyzer with fluorescence detection. Clin Chem 27: 256, 1981

Phillips RW , and Manildi ER : Abnormal serum isoenzyme of leucine aminopeptidase (LAP) in malignant neoplastic disease. Cancer 34: 350–357, 1974

Pierzchala PA , Dorn CP , Zimmerman M : A new fluorogenic substrate for plasmin. Biochem J 183: 555, 1979

Planta RJ , Gruber MA : A simple estimation of cathepsin C using a new chromogenic substrate. Anal Biochem 5: 360, 1963.

Quigley JP , Goldfarb RH , Scheiner C , O'Donnell-Tormey J , Yeo TK : Plasminogen activator and the membrane of transformed cells. In Tumor Cell Surfaces and Malignancy. Edited by Hynes R , Fox CF , Alan R Liss, New York, 1980, p 773

Recklies AD , Mort JS , Poole AR : Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization. Cancer Res 42: 1026, 1982

Riedel A , Wünsch E : NΑ-Benzoyl-arginin-β-naphthylamid als Substrat zur quantitativen kolorimetrischen Bestimmung. Hoppe Seylers Z Physiol Chem 316: 61, 1959

Rosenblatt DH , Nachlas MM , Seligman AM : Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates. J Am Chem Soc 80: 2463, 1958

Sannes PL : Changes in lung proteases associated with bleomycin-induced interstitial fibrosis. J Histochem Cytochem 30: 574, 1982

Schechter I , Gerger A : On the size of the active site in proteases I., Papain. Biochem Biophys Res Commun 27: 157, 1967

Sekine T , Itakura H , Namihisa T , Takahashi T , Nakayama H , Kanaoka Y : A novel fluorometric ukramicro determination of serum γ-glutamyltranspeptidase activity. Chem Pharm Bull 29: 3286, 1981

Sharoni Y , Topal MC , Tuttle PR , Berger H Jr : A comparison of plasminogen activators derived from rat plasma, primary rat hepatocytes and isolated perfused rat liver. Thromb Haemostas (Stuttgart) 47: 166, 1982

Sherry S , Troll W : The action of thrombin on synthetic substrates. J Biol Chem 208: 95, 1954

Sinha P , Gossrau R : Histochemical studies with MNA substrates using isoelectric focusing. J Histochem Cytochem 30: 575, 1982

Slaughter CA , Coseo MC , Cancro MP , Harris H : Detection of enzyme polymorphism by using monoclonal antibodies. Proc Natl Acad Sci USA 78: 1124, 1981

Sloane BF , Honn KV , Sadler JG , Turner WA , Kimpson JJ , Taylor JD : Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential. Cancer Res 42: 980, 1982

Smith RE , Smithwick EL Jr Allen CH : A new assay for cathepsin B1 using CBZ-Ala-Arg-Arg-4-MeO-β-NA. Presented at the Histochemical Society Twenty-Third Annual Meeting, Boston, MA, 1972

Smith RE , Grabske RJ : Isozymes of glandular kallikrein revealed by isoelectric focusing and fluorescence staining with an oligopeptide substrate impregnated into cellulose. J Histochem Cytochem 30: 575, 1982

Smith RE , Pearson KW , Mitchell AR , Bissell ER , King EB : An automated system for analysis of serum cathepsin B-like activity in detection of neoplastic disease. AB. 349 Cancer Treatment Reports 63:1212, July 1979, U.S. Dept. of Health, Education and Welfare, Washington, DC

Smith RE , Van Frank RM : The use of amino acid derivatives of 4-methoxy-β-naphthylamine for the assay and subcellular localization of tissue proteinases. In Lysosomes in Biology and Pathology, vol. 4. Edited by Dingle JT , Dean RT Elsevier/North-Holland Press, New York, 1975, p 193–249

Svendsen L , Blomback B , Blomback M , Olsson P : I. Synthetic chromogenic substrates for determination of trypsin, thrombin, and thrombin-like enzymes. Thromb Res 1: 267, 1972

Tuppy H , Nesvadba H : Uber die Aminoptidaseaktivität des Schwangerenserums und ihre Beziehung zu dessen Vermögen, Oxytocin zu inaktivieren. Monatsschr Chim 88: 977, 1957

Vanderlaan M , Phares W : γ-Glutamyltranspeptidase: a tumour cell marker with a pharmacological function. Histochem J 13: 865, 1981

Wang BS , McLoughlin GA , Richie JP , Mannick JA : Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines. Cancer Res 40: 288, 1980

Weber A , Poenaru L , Lafarge C , Schapira F : Modification of hexosaminidase isozymes in rat hepatoma. Cancer Res 33: 1925, 1973

Weinhouse S : What are isozymes telling us about gene regulation in cancer? J Natl Cancer Inst 68:343, 1982

Whur P , Magudia M , Boston J , Lockwood J , Williams DC : Plasminogen activator in cultured Lewis lung carcinoma cells measured by chromogenic substrate assay. Br J Cancer 42: 305, 1980

Yamamoto H , Sumikawa K , Hada T , Higashino K , Yamamura Y : γ-Glutamyltransferase from human hepatoma tissue in comparison with normal liver enzyme. Clin Chim Acta 111: 229, 1981

Yamato S , Hirabayashi Y , Uematsu H , Sugihara H : Histo- and cytochemical studies of cathepsin D using a specific inhibitor, pepstatin. J Histochem Cytochem 30: 597, 1982

Yoshii Y , Kasugai T , Kato T , Nagatsu T , Sakakibara S : Changes in serum dipeptidyl-aminopeptidase IV (glycylprolyl dipeptidyl-aminopeptidase) activity of patients with gastric carcinoma after surgical excision and the enzyme activity in the carcinoma tissue. Biochem Med 25: 276, 1981

Zimmerman M , Ashe BM : Substrate specificity of the elastase and the chymotrypsin-like enzyme of the human granulocyte. Biochim Biophys Acta 480: 241, 1977

Zimmerman M , Quigley JP , Ashe B , Dorn C , Goldfarb R , Troll W : Direct fluorescent assay of urokinase and plasminogen activators of normal and malignant cells: kinetics and inhibitor profiles. Proc Natl Acad Sci USA 75: 750, 1978

Zimmerman M , Mumford RA , Steiner DF (Eds): Precursor processing in the biosynthesis of proteins. Ann NY Acad Sci 343: 1, 1980