Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder characterized by overactivation of the immune system leading to disordered multiorgan inflammation. Allogeneic stem cell transplantation is the required curative treatment of primary HLH.
Method: An infant prenatally diagnosed with HLH mutation presented with necrotic cellulitis. Our interdisciplinary team of specialists collaborated to implement early and aggressive supportive wound care strategies, including skin care for high-risk stem cell transplant patients.
Results: The patient subsequently underwent allogeneic stem cell transplant with minimal complications and positive outcomes, despite entering the transplant with open skin lesions.
Discussion: This complex case highlights the efforts of a multidisciplinary team to partner with the family to provide supportive care to optimize wound healing and improve outcomes.
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