Abstract
Background:
It has been hypothesized that achalasia might result from a type 2 inflammatory disorder that draws activated eosinophils and/or mast cells into esophageal muscle.
Methods:
To seek support for this hypothesis, we probed an existing RNA-sequencing dataset from esophageal biopsies of achalasia patients for molecular signatures of type 2 inflammation.
Results:
Mucosal biopsies from achalasia patients showed significant enrichment for IL-4 response genes, and 7 of 14 patients exhibited unique gene expression signatures of type 2 inflammation.
Conclusion:
These findings are consistent with the hypothesis that a subset of achalasia patients exhibits a mucosal type 2 inflammatory transcriptome.
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