Crigler Najjar syndrome is a rare, autosomal recessive disorder of bilirubin metabolism. The syndrome is very rare and only a few cases have been reported in adults. We present a case of 22-year-old female who developed rapidly progressive jaundice following normal vaginal delivery accompanied with encephalopathy. We present this unusual case of bilirubin encephalopathy in a post-partum female which was diagnosed to be Crigler Najjar syndrome type II with compound heterozygous mutation. Our patient showed significant improvement with phenobarbital and plasmapheresis. The rarity of the case and its significant response to the treatment modalities prompted us to report this case.
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