Two Sides of the Same Coin: Understanding the Interplay of Hyperglycemia and Dyslipidemia Is Needed to Break the Cycle of Metabolic Dysregulation in Diabetes Management
Restricted accessResearch articleFirst published online 2025
Two Sides of the Same Coin: Understanding the Interplay of Hyperglycemia and Dyslipidemia Is Needed to Break the Cycle of Metabolic Dysregulation in Diabetes Management
AthyrosVGDoumasMImprialosKP, et al. Diabetes and lipid metabolism. Hormones (Athens). 2018;17(1):61-67. doi:10.1007/s42000-018-0014-8
2.
CerfME.Beta cell dysfunction and insulin resistance. Front Endocrinol. 2013;4:37. doi:10.3389/fendo.2013.00037
3.
BodenG.Free fatty acids—the link between obesity and insulin resistance. Endocr Pract. 2001;7(1):44-51. doi:10.4158/EP.7.1.44
4.
CerielloAEspositoKPiconiL, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes. 2008;57(5):1349-1354. doi:10.2337/db08-0063
5.
ChenXXieNFengL, et al. Oxidative stress in diabetes mellitus and its complications: from pathophysiology to therapeutic strategies. Chin Med J. 2025;138(1):15-27. doi:10.1097/CM9.0000000000003230
6.
DanielMJ.Lipid management in patients with type 2 diabetes. Am Health Drug Benefits. 2011;4(5):312-322.
7.
American Diabetes Association. Standards of Care in Diabetes — 2025. Diabetes Care. 2025;48(suppl. 1):S150-S175.
8.
YangDRWangMYZhangCLWangY.Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications. Front Endocrinol. 2024;15:1359255. doi:10.3389/fendo.2024.1359255
9.
MourâoDMSantosGMSDuarteGC.Enhancing diabetes self-management through the AADE7 Self-Care Behaviors framework: an observational study. Einstein. 2025;23:eAO1213. doi:10.31744/einstein_journal/2025AO1213
10.
PowersMABardsleyJCypressM, et al. Diabetes self-management education and support in adults with type 2 diabetes: a consensus report of the ADA, AADE, and AND. Diabetes Educ. 2020;46(4):350-369. doi:10.1177/0145721720930959
11.
FranzMJMacLeodJEvertA, et al. Academy of Nutrition and Dietetics nutrition practice guideline for type 1 and type 2 diabetes in adults: systematic review of evidence for medical nutrition therapy effectiveness and recommendations for integration into the nutrition care process. J Acad Nutr Diet. 2017;117(10):1659-1679. doi:10.1016/j.jand.2017.03.022
12.
McMurrayJJVSolomonSDInzucchiSE, et al. Dapa-gliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa1911303
13.
ChaeYKwonSHNamJH, et al. Lipid profile changes induced by glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a systematic review and network metaanalysis. Expert Rev Clin Pharmacol. 2024;17(8):721-729. doi: 10.1080/17512433.2024.2363838
14.
Centers for Disease Control and Prevention. Rural-urban disparities in state-level diabetes prevalence among adults — United States, 2021. Prev Chronic Dis. 2024;21:E72. doi:10.5888/pcd21.230006
15.
DavisRMHitchADSalaamMMHermanWHZimmer-GallerIEMayer-DavisEJ.TeleHealth improves diabetes self-management in an underserved community: Diabetes TeleCare. Diabetes Care. 2010;33(8):1712-1717. doi:10.2337/dc09-1919