Abstract
Depression and sexual problems are mutually related and one can lead to the other. Both are bio-psycho-social problems and need to be looked into holistically. Whether causation, effect or whenever, wherever they need help, it is important to incorporate all the modalities prudently. The picture emphasizes strong reference to biology and brain on the one hand and psychosocial domain on the other hand, and judicious and eclectic approaches are needed to set the suffering individual free from distress and to help them fly again. The timely help from near and dear ones and professionals needs no emphasis.