Targeted phototherapy for treatment of localized psoriasis has advantages over non-targeted phototherapy. It delivers high ultraviolet doses to only the diseased skin, sparing irradiation to normal skin.
Objective
This study aims to review the devices that are available for targeted treatment of psoriasis.
Evidence Review
A PubMed literature review was conducted to identify devices for localized psoriasis phototherapy. Device manufacturer websites were searched for specific information.
Findings
Eighty-four papers were identified that met the inclusion criteria. We identified and described seven laser/light therapies and 22 devices for localized psoriasis treatment.
Limitations
There is potential bias for each device since the products’ information was provided by their manufacturer. Some devices were excluded due to lack of relevant information.
Conclusions and Relevance
Excimer laser and narrow band ultraviolet B devices are valuable treatment modalities for localized psoriasis. Handheld, narrow band ultraviolet B devices are efficacious and available for home treatment.
NakamuraM.FarahnikB.BhutaniT.. Recent advances in phototherapy for psoriasis.F1000Res.2016; 5.
2.
SteinK.R.PearceD.J.FeldmanS.R.. Targeted UV therapy in the treatment of psoriasis.J Dermatolog Treat.2008; 19(3): 141–145.
3.
AlshiyabD.EdwardsC.ChinM.F.AnsteyA.V.. Targeted ultraviolet B phototherapy: definition, clinical indications and limitations.Clin Exp Dermatol.2015; 40(1): 1–5.
4.
TanghettiE.GillisP.R.. Photometric and clinical assessment of localized UVB phototherapy systems for the high-dosage treatment of stable plaque psoriasis.J Cosmet Laser Ther.2003; 5(2): 101–106.
TaibjeeS.M.CheungS.T.LaubeS.LaniganS.W.. Controlled study of excimer and pulsed dye lasers in the treatment of psoriasis.Br J Dermatol.2005; 153(5): 960–966.
8.
KöllnerK.WimmershoffM.B.HintzC.LandthalerM.HohenleutnerU.. Comparison of the 308-nm excimer laser and a 308-nm excimer lamp with 311-nm narrowband ultraviolet B in the treatment of psoriasis.Br J Dermatol.2005; 152(4): 750–754.
9.
LevinA.A.AleissaS.DumontN.A randomized, prospective, sham-controlled study of localized narrow-band UVB phototherapy in the treatment of plaque psoriasis.J Drugs Dermatol.2014; 13(8): 922–926.
10.
MehrabanS.FeilyA.. 308nm excimer laser in dermatology.J Lasers Med Sci.2014; 5(1): 8–12.
GattuS.PangM.L.PugashettiR.Pilot evaluation of supraerythemogenic phototherapy with excimer laser in the treatment of patients with moderate to severe plaque psoriasis.J Dermatolog Treat.2010; 21(1): 54–60.
13.
DebbanehM.G.LevinE.Sanchez RodriguezR.LeonA.KooJ.RosenblumM.D.. Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient.J Dermatolog Treat.2015; 26(1): 45–48.
14.
MudigondaT.DabadeT.S.FeldmanS.R.. A review of protocols for 308 nm excimer laser phototherapy in psoriasis.J Drugs Dermatol.2012; 11(1): 92–97.
15.
HadiS.M.Al-QuranH.de Sá EarpA.P.HadiA.S.LebwohlM.. The use of the 308-nm excimer laser for the treatment of psoriasis.Photomed Laser Surg.2010; 28(5): 693–695.
16.
MehtaD.LimH.W.. Ultraviolet B Phototherapy for Psoriasis: Review of Practical Guidelines.Am J Clin Dermatol.2016; 17(2): 125–133.
17.
FikrleT.PizingerK.. [The use of the 308 nm excimer laser for the treatment of psoriasis].J Dtsch Dermatol Ges.2003; 1(7): 559–563.
18.
MaviliaL.MoriM.RossiR.CampolmiP.Puglisi GuerraA.LottiT.. 308 nm monochromatic excimer light in dermatology: personal experience and review of the literature.G Ital Dermatol Venereol.2008; 143(5): 329–337.
19.
MudigondaT.DabadeT.S.FeldmanS.R.. A review of targeted ultraviolet B phototherapy for psoriasis.J Am Acad Dermatol.2012; 66(4): 664–672.
20.
LapidothM.AdattoM.DavidM.. Targeted UVB phototherapy for psoriasis: a preliminary study.Clin Exp Dermatol.2007; 32(6): 642–645.
21.
GoldingerS.M.DummerR.SchmidP.Prinz VavrickaM.BurgG.LauchliS.. Excimer laser versus narrow-band UVB (311 nm) in the treatment of psoriasis vulgaris.Dermatology.2006; 213(2): 134–139.
HaykalK.A.DesGroseilliersJ.P.. Are narrow-band ultraviolet B home units a viable option for continuous or maintenance therapy of photoresponsive diseases?J Cutan Med Surg.2006; 10(5): 234–240.
24.
BerneburgM.HerzingerT.RampfJ.Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study.Br J Dermatol.2013; 169(3): 704–708.
25.
Pozo-RománT.González-LópezA.Velasco-VaqueroM.E.Núñez-CabezónM.. Psoralen cream plus ultraviolet A photochemotherapy (PUVA cream): our experience.J Eur Acad Dermatol Venereol.2006; 20(2): 136–142.
26.
AlmutawaF.ThalibL.HekmanD.SunQ.HamzaviI.LimH.W.. Efficacy of localized phototherapy and photodynamic therapy for psoriasis: a systematic review and meta-analysis.Photodermatol Photoimmunol Photomed.2015; 31(1): 5–14.
27.
NeumannN.J.MahnkeN.KorpusikD.StegeH.RuzickaT.. Treatment of palmoplantar psoriasis with monochromatic excimer light (308-nm) versus cream PUVA.Acta Derm Venereol.2006; 86(1): 22–24.
28.
NolanB.V.YentzerB.A.FeldmanS.R.. A review of home phototherapy for psoriasis.Dermatol Online J.2010; 16(2): 1.
29.
Introducing The Pioneering XTRAC Velocity™ Excimer Laser: Delivers Psoriasis And Vitiligo Treatments Three Times Faster [press release].Business Wire2009.
30.
XTRAC Ultra: Laser Therapy for Psoriasis.PhotoMedex; 2005.
