Prevention of Tuberculosis Infections in Patients Considered for Anti-TNF-α Therapy: Practical Application of National Psoriasis Foundation Consensus Statement
Restricted accessOtherFirst published online March, 2010
Prevention of Tuberculosis Infections in Patients Considered for Anti-TNF-α Therapy: Practical Application of National Psoriasis Foundation Consensus Statement
Tumor necrosis factor inhibitors have been linked to increased Mycobacterium tuberculosis infections. In order to standardize treatment and minimize risks to patients, the National Psoriasis Foundation (NPF) issued a consensus statement on patient management regarding this issue, including advice on when to use the FDA-approved QuantiFERON® TB Gold screening test. The evidence-based guidelines developed in the Psoriasis Foundation statement are summarized in a practical clinical algorithm, which we have applied to the management of a patient with severe psoriasis. Proper utilization of this algorithm clarifies the risks and benefits balance of using these biologics. In general, the tumor necrosis factor-alpha (TNF-α) inhibitors possess impressive rates of efficacy in the treatment of psoriasis and relatively fewer adverse effects when compared with other systemic immunosuppressants.
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