Purpose: To compare the outcomes of phakic and pseudophakic eyes with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR) that underwent pars plana vitrectomy (PPV) with retinectomy. Methods: A retrospective matched cohort study was performed in patients who underwent PPV with retinectomy for RRD with PVR with a minimum follow-up of 6 months. Phakic eyes that did not undergo lensectomy were matched to pseudophakic control eyes in a 1:1 ratio for age, gender, and macular status. The main outcome measure was single-surgery anatomic success at 6 months. Results: The study included 138 eyes (69 in each of the phakic and pseudophakic groups). The mean follow-up duration was 28.7 ± 9.2 months. Baseline characteristics, including macular status, preoperative visual acuity (VA), and RRD extent and retinectomy did not differ significantly between groups. The single-surgery anatomic success after initial retinectomy did not differ significantly between the phakic and pseudophakic groups at 3 months (69.6% vs 82.6%, respectively; P = .110) or 6 months (56.6% vs 66.7%, respectively; P = .294). The final retinal reattachment was achieved in 98.6% of the phakic group and 97.1% of the pseudophakic group (P > .99). Both groups showed significant visual improvement at 6 months and final follow-up visit (P < .05). Postoperative VA did not differ significantly between groups (P > .05). Conclusions: Eyes that underwent retinectomy for RRD with PVR may achieve acceptable outcomes regardless of the lens status. There was no difference in outcomes between phakic eyes that did not undergo lensectomy and pseudophakic eyes.