Purpose: To describe pseudoexfoliation glaucoma, the most common cause of secondary open-angle glaucoma, and its role in predisposing patients to lens dislocation owing to aggregation of fibrillar extracellular material on the zonules. Methods: Case report and retrospective review. Results: We describe a 78-year-old man with pseudoexfoliation glaucoma and a visually significant epiretinal membrane who experienced spontaneous crystalline lens dislocation during initiation of core vitrectomy with membrane peel. Phacofragmentation was performed to remove the dislocated crystalline lens. Conclusions: This case highlights pseudoexfoliation glaucoma as a risk factor for crystalline lens dislocation during core vitrectomy. Awareness of this complication can influence preoperative counseling and improve surgical planning.
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