Purpose: To report a patient with a sub-inner limiting membrane (ILM) hemorrhage secondary to dengue fever treated with neodymium:YAG (Nd:YAG) laser hyaloidotomy. Methods: A single case was evaluated. Results: A 41-year-old man presented with sudden vision loss in the left eye 10 days after being diagnosed with dengue fever. Funduscopy showed a sub-ILM macular hemorrhage in the left eye. Out of concern for retinal toxicity and to quickly restore visual acuity (VA), an Nd:YAG laser hyaloidotomy was performed. One month after the procedure, the logMAR VA in the left eye improved from 0.1 to 1.0 with complete resolution of the hemorrhage. Conclusions: Given the substantial increase in cases of dengue fever and its possible ophthalmologic involvement, this case highlights the importance of an ophthalmologic examination with funduscopy in patients with a sub-ILM hemorrhage and the possibility of treatment with an Nd:YAG laser.
BhattSGethingPWBradyOJ, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-507.
2.
KapoorHKBhaiSJohnMXavierJ.Ocular manifestations of dengue fever in an East Indian epidemic. Can J Ophthalmol. 2006;41(6):741-746.
3.
GuptaASrinivasanRSetiaSSoundravallyRPandianDG.Uveitis following dengue fever. Eye (Lond). 2008;23(4):873-876. doi:10.1038/eye.2008.124
4.
KováčováMKousalBMeliškaMFichtlMDuškováJKalvodováB.Treatment options for premacular and sub-internal limiting membrane hemorrhage. Cesk Slov Oftalmol. 2021;77(6):289-294.
5.
GibranSKKenawyNWongDHiscottP.Changes in the retinal inner limiting membrane associated with Valsalva retinopathy. Br J Ophthalmol. 2007;91(5):701-702.
LinCYKolliopoulosCHuangCH, et al. High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity. EBioMedicine. 2019;48:425-441.
8.
RubensteinRAYanoffMAlbertDM.Thrombocytopenia, anemia, and retinal hemorrhage. Am J Ophthalmol. 1968;65(3):435-439.
9.
AmbastaAKusumeshRAliMBhaskarGAkankshaSPragyaV.Causes of vision loss associated with dengue fever in Bihar, India - a case series. Am J Trop Med Hyg. 2024;110(6):1172-1177.
10.
ChangPYWangJKYangCH.Spectral-domain optical coherence tomography findings of subinternal limiting membrane hemorrhage in the macula before and after Nd:YAG laser treatment. Taiwan J Ophthalmol. 2015;5(1):33-35.
11.
ShuklaDNareshKBKimR.Optical coherence tomography findings in Valsalva retinopathy. Am J Ophthalmol. 2005;140(1):134-136.
12.
MalekMANiyonzimaJCPathanMAHKRahmanMM.Pars plana vitrectomy for a sub-internal limiting membrane hemorrhage and vitreous hemorrhage secondary to dengue fever: a case report. Cureus. 2022;14(6):e25916.
13.
KumarAAmbiyaVBaranwalVKAroraAKapoorG.Pneumatic displacement of a dense sub-inner limiting membrane pre-macular hemorrhage in dengue maculopathy: a novel treatment approach. Turk J Ophthalmol. 2019;49(1):51-54.
14.
UlbigMWMangouritsasGRothbacherHHHamiltonAMMcHughJD.Long-term results after drainage of premacular subhyaloid hemorrhage into the vitreous with a pulsed Nd:YAG laser. Arch Ophthalmol. 1998;116(11):1465-1469.
15.
MurtazaFRizviSFBokhariSAKamilZ.Management of macular pre-retinal subhyaloid hemorrhage by Nd:Yag laser hyaloidotomy. Pak J Med Sci. 2014;30(2):339-342.
