Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C

Abstract

Purpose: To report a case of suprachoroidal migration of mitomycin-C (MMC) with ensuing retinal toxicity after trabeculectomy. Methods: A case report of retinal toxicity is described with multimodal imaging. Results: A patient developed occlusion of the retinal and choroidal vasculature in a segmental fashion that could be explained by suprachoroidal diffusion. Fundus autofluorescence showed a stippled pattern over an area of hypofluorescence in the superonasal quadrant, and a late fluorescein angiogram image showed staining of the superonasal quadrant with dependent leakage toward the optic nerve and macula. Conclusions: MMC is commonly used in glaucoma-filtering surgical procedures, and few cases of postoperative posterior segment toxicity have been reported. To our knowledge, we are the first to describe suprachoroidal migration of MMC with subsequent retinal toxicity.