Optimizing compressive mechanical properties and water absorption of polycaprolactone/nano-hydroxyapatite composite scaffolds by 3D printing based on fused deposition modeling

Abstract

This research examines the mechanical properties and water absorption of polycaprolactone (PCL) scaffolds reinforced with nano-hydroxyapatite (N-HA) particles, printed using a 3D printer based on fused deposition modeling (FDM) technology. Fabricating this composite material aims to replicate a tissue similar to bone tissue. Biocompatible N-HA (50% by weight) was utilized to fortify the matrix phase and enhance the mechanical properties. The compression test results showed that the addition of N-HA augmented the compressive strength and modulus of the scaffolds (with a nominal porosity of 60% and a filling pattern of 0/60/120) by 240% and 150%, respectively. Moreover, the water absorption increased by 600%.

Keywords

3D printer additive manufacturing bone scaffold polycaprolactone hydroxyapatite nanoparticles

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References

Karchin

Simonovsky

Ratner

, et al. Melt electrospinning of biodegradable polyurethane scaffolds. Acta Biomater 2011; 7: 3277–3284.

Zhang

Cao

Zaeri

, et al. Design, fabrication, and characterization of tubular scaffolds by way of a melt electrowriting process. Addit Manufact 2023; 62: 103383.

Agarwal

García

AJ.

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair. Adv Drug Deliv Revs 2015; 94: 53–62.

McKeen

12 - Renewable resource and biodegradable polymers. In: McKeen

(ed.) The effect of sterilization on plastics and elastomers. 3rd ed. Boston: William Andrew Publishing, 2012, pp.305–317.

Ulery

Nair

Laurencin

CT.

Biomedical applications of biodegradable polymers. J Polym Sci B Polym Phys 2011; 49: 832–864.

Akhoundi

Hajami

Extruded polymer instability study of the polylactic acid in fused filament fabrication process: printing speed effects on tensile strength. Polym Eng Sci 2022; 62: 4145–4155.

Akhoundi

Modanloo

Investigation and feasibility of printing polyoxymethylene semi-crystalline polymer parts with fused filament fabrication 3D printer and evaluation of mechanical properties of the printed samples. J Mater Eng Perform. Epub ahead of print 21 August 2023. DOI: 10.1007/s11665-023-08619-5.

Akhoundi

Nabipour

Hajami

, et al. An experimental study of nozzle temperature and heat treatment (annealing) effects on mechanical properties of high-temperature polylactic acid in fused deposition modeling. Polym Eng Sci 2020; 60: 979–987.

Karageorgiou

Kaplan

Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005; 26: 5474–5491.

10.

Groppo

Caria

Freire

, et al. The effect of a hydroxyapatite impregnated PCL membrane in rat subcritical calvarial bone defects. Arch Oral Biol 2017; 82: 209–215.

11.

Buyuksungur

Tanir

Buyuksungur

, et al. 3D printed poly (ε-caprolactone) scaffolds modified with hydroxyapatite and poly (propylene fumarate) and their effects on the healing of rabbit femur defects. Biomater Sci 2017; 5: 2144–2158.

12.

Akhoundi

Sousani

. An experimental investigation of screw-based material extrusion 3D printing of metallic parts. J Eng Res 2023: 100102. https://doi.org/10.1016/j.jer.2023.100102.