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Abstract

Background:

The understanding of pediatric anterior cruciate ligament (ACL) injuries and optimal treatment has evolved significantly. Influential articles have been previously evaluated using article citations to determine impact.

Purpose:

To identify and characterize the 50 most cited and recent influential articles relating to pediatric and adolescent ACL injuries, to examine trends in publication characteristics, and to evaluate correlations of study citations with quality of evidence.

Study Design:

Cross-sectional study.

Methods:

The top 50 most cited articles on pediatric and adolescent ACL injuries were gathered using the Web of Science and Scopus online databases by averaging the number of citations from each database. Articles from recent years were also aggregated and sorted by citation density (citations/year). Publication and study characteristics were recorded. Level of evidence and methodologic quality were assessed where applicable using the modified Coleman Methodology Score (mCMS), modified Jadad scale, and Methodological Index for Non-Randomized Studies (MINORS). Spearman correlation was used to evaluate the association between citation data and level of evidence or methodologic quality scorings.

Results:

The top 50 cited papers had a mean of 117.5 ± 58.8 citations (range, 58.5-288.5 citations), with a mean citation density of 9.4 ± 5.4 citations per year (range, 2.9-25.8 citations/year); 80% were published in 2000 or later, and 6% were considered basic science. Articles were mainly level 4 evidence (27/42; 64.3%), and none was level 1. There were moderate, significant associations between publication year and level of evidence (r _S = −0.45; P = .0030) and citation density and publication year (r _S = 0.59; P < .001). Mean methodologic quality scores were as follows: mCMS, 53 ± 7.2 (range, 39-68); modified Jadad scale, 3.2 ± 1.1 (range, 2-6); and MINORS, 11.2 ± 3.2 (range, 6-20). There was a significant, strong correlation between rank of mean citations and modified Jadad scale (r _S = 0.76; P < .0001), suggesting poorer score associated with more mean citations.

Conclusion:

Influential articles on pediatric and adolescent ACL injuries were relatively recent, with a low proportion of basic science–type articles. Most of the studies had a lower evidence level and poor methodologic quality scores. Higher methodologic quality did not correlate positively with citation data.

Keywords

anterior cruciate ligament pediatric sports medicine adolescent skeletally immature quality influential

Pediatric and adolescent anterior cruciate ligament (ACL) injuries necessitate different considerations than do similar injuries in adults. Although this population also may endure tibial spine avulsion injuries, there has been increasing recognition of ACL ruptures in recent years. To minimize the risk of growth disturbance and deformity, surgical treatment of ACL tears in skeletally immature patients historically was delayed until physes were closed or nearly closed.

However, natural history studies^{5,34,53,64,65,70,80} have demonstrated poor return-to-sports outcomes and increased incidence of meniscal and chondral injuries with delayed reconstruction or conservative management in those returning to high-risk activity. Therefore, advances in techniques such as combined intra- and extra-articular reconstructions using the iliotibial band⁴⁵ and other physeal-sparing techniques have gained popularity in those with substantial years of growth remaining.

Similarly important to the consideration of growth disturbance is the high rate of reinjury. Despite appropriate reconstruction, pediatric patients have a substantial rate of graft reinjury after reconstruction, owing in part to their return to high activity levels.^13,84 Furthermore, understanding of graft selection and notably the poor outcomes using allograft in young cohorts have guided utilization of autograft tissues.³⁸ The understanding of the unique considerations in managing ACL injuries in pediatric and adolescent patients, and in particular those who are skeletally immature, continues to develop with further research and outcome data.

To continue progression of understanding and optimization of outcomes, it is beneficial to evaluate previous literature and previous advances in treatment strategies. In orthopaedics, there has been recent emphasis on evaluating influencial articles. While several approaches have been undertaken to identify top articles, the number of citations for a study has been recently utilized as a surrogate for influence.^{17,31,40,42,59,77,81,82} By evaluating individual study citations, limitations of using a journal’s impact factor are avoided.¹⁴ Aggregating commonly cited and influential studies also provides insight into foundational literature for learners.

In addition to guiding further topics of research, evaluating influential articles demonstrates the types of studies and quality of the top cited papers. It is notable, however, that in orthopaedics, authors have highlighted the poor correlation or lack thereof between quality of evidence and number of citations.⁷⁷ Elucidating further details of article characteristics of the highly cited articles may also help guide future study designs after identifying gaps in the highly cited literature. Although some have evaluated influential articles on ACL injuries^31,81,82 and pediatric orthopaedics,^40,67 there have been no similar studies on pediatric and adolescent ACL injuries specifically.

The purpose of the present study was to identify and characterize the 50 most cited and recent influential articles relating to pediatric and adolescent ACL injuries, to examine trends in publication characteristics, and to evaluate correlations of study citations with quality of evidence. We hypothesized that the top 50 cited articles would contain few high-level evidence studies as well as citations that would have poor correlation with methodologic quality.

Methods

The methods for this bibliometric analysis were adapted and modified from previous studies.^2,77 An online search query was performed using the (1) Web of Science (all databases) and (2) Scopus online databases. These databases were selected because of their ability to search independent terms and present the number of citations per article. The following search terms and Boolean operators were utilized to identify articles with titles relating to pediatric and adolescent ACL reconstruction: ((pediatric) OR (adolescent) OR (skeletally immature)) AND ((anterior cruciate ligament) OR (ACL)). The search was performed using each database on September 5, 2020. All included articles were exported from the databases for initial review.

The articles were sorted on each database from highest to lowest number of citations. Four authors (S.A., D.A.L., N.K.P., B.T.F.) evaluated 100 articles from each database for inclusion with the topic relating to pediatric and adolescent ACL reconstruction. Articles referring to other topics were excluded. All study types were included, including laboratory and animal studies. The number of citations from each database was averaged for each study, and the articles were re-sorted to generate a top 50 list from the average number of citations from most to least.

Rank was assigned, with 1 being the most cited and 50 being the least cited in the list. The terms “better” or “higher” rank refer to those articles with more citations, while the terms “worse” or “lower” rank refer to those with fewer citations. In addition to citations and rank, the following data were collected from each study: digital object identifier or PubMed ID, title, authors, publication year, journal, and country of origin. The approximated citation density (citations/year) was calculated from the average citations divided by the number of years since publication. Each article was assigned a publication decade based on publication year.

The search was repeated using the databases on the same date, limiting the years to between 2010 and 2019 to generate a top 10 list of recent publications, ranked and sorted by citation density. Furthermore, the top cited article from each individual year between 2010 and 2019 was noted.

For the top 50 articles, the authors reviewed each study to classify study type (ie, survey, case series, cohort study, case-control, randomized controlled trial, animal study, biomechanical/cadaveric, imaging/diagnostic, meta-analysis/systematic review, technique/review), and they assigned and agreed on retrospective versus prospective evaluation, study category (diagnostic, prognostic, therapeutic), and level of evidence. Level of evidence was defined based on the Center for Evidence-Based Medicine guidelines. Retrospective versus prospective evaluation, study category, and level of evidence were not assigned to animal studies, or biomechanical/cadaveric studies. Meta-analysis/systematic review articles were assigned a level of evidence, but technique or narrative review articles were not.

Methodologic quality of studies was evaluated using a variation of the modified Coleman Methodology Score (mCMS), a variation of the modified Jadad scale, and Methodological Index for Non-Randomized Studies (MINORS).^19,36,76 The mCMS has a minimum score of 0 and maximum score of 100.^58,71 The version of the modified Jadad scale utilized is an 9-point scale, with a minimum score of 0 and a maximum score of 8.^18,75,86 The MINORS criteria has a scoring range of 0 to 16 for noncomparative studies and 0 to 24 for comparative studies.⁷⁶ Scoring using mCMS was applied only to studies focusing on surgical treatment, and MINORS was not applied to randomized studies. Animal, biomechanical/cadaveric, case report, cross-sectional, imaging/diagnostic, meta-analysis/systematic review, technique/review, and survey studies were not assessed for methodologic quality.

Data were aggregated and presented utilizing descriptive statistics. The Spearman correlation coefficient (r _S) was used to evaluate the association between citation data (rank of mean number of citations, citation density) and level of evidence and methodologic quality scorings. Correlation was also assessed between publication year and level of evidence. The strength of correlation was determined using the absolute value of r _S: weak, <0.4; moderate, 0.4 to 0.7; and strong, >0.7.²⁰ One-way analysis of variance was performed to evaluate the differences between citations and citation density by level of evidence. Independent-samples t test was performed to compare the citation density of the top 10 from the overall top 50 cited articles list and the top 10 between 2010 and 2019. Significance was set at P < .05 for 2-tailed testing.

Results

The initial database searches revealed 463 titles using Web of Science and 478 titles using Scopus. The top 50 most cited articles were published between 1986 and 2017 and are listed in Appendix Table A1. The mean ± standard deviation (SD) difference in citation numbers for individual articles between the Web of Science and Scopus databases was 28.4 ± 19.6 (range, 1-89 citations). The Scopus database yielded a larger number of citations for all articles except 1.²³ The mean number of citations was 117.5 ± 58.8 (range, 58.5-288.5 citations). The mean citation density was 9.4 ± 5.4 citations per year (range, 2.9-25.8 citations/year).

Eighty percent (40/50) of the top 50 articles were published in the year 2000 or later (Figure 1). Articles were published in 15 different journals. The most common journal was the American Journal of Sports Medicine, representing 13 (26%) of the articles. Together, the American Journal of Sports Medicine, the Journal of Bone & Joint Surgery, and Arthroscopy represented the majority (32; 64%) of the articles (Figure 2). The most common country of origin was the United States (41; 82%) (see Appendix Table A1).

Figure 1.

Number of 50 most cited articles relating to pediatric and adolescent anterior cruciate ligament reconstruction by decade of publication.

Figure 2.

Number of 50 most cited articles relating to pediatric and adolescent anterior cruciate ligament reconstruction by journal of publication. Journal titles are listed according to PubMed abbreviation.

Of the 42 studies assigned a level of evidence score, the majority (27; 64.3%) were level 4, and no studies were level 1 (Figure 3). Nineteen (38%) were classified as case series (Figure 4). Only 3 (6%) were considered basic science (1 animal,⁶⁹ 2 biomechanical/cadaveric^11,43). Moreover, 76.5% (26/34) applicable clinical studies were retrospective. Thirty-seven studies were classified into categories, of which fifteen (40.5%) studies were prognostic, 13 (35.1%) were therapeutic, and 9 (24.3%) were diagnostic in nature (see Appendix Table A1).

Figure 3.

Number of 50 most cited articles relating to pediatric and adolescent anterior cruciate ligament reconstruction by assigned level of evidence. Articles classified as animal studies, biomechanical/cadaveric studies, or technique/review articles were excluded from level of evidence analysis (n = 8 excluded; total n = 42 included in level of evidence analysis).

Figure 4.

Proportion of 50 most cited articles relating to pediatric and adolescent anterior cruciate ligament reconstruction by study design type.

In total, 27 studies were assessed for at least 1 methodologic quality scoring in total (Appendix Table A1). The 23 studies not evaluated for methodologic quality included 1 animal study,⁶⁹ 2 biomechanical/cadaveric,^11,43 1 case report,⁵⁰ 1 cross-sectional,²⁴ 2 descriptive epidemiology,^22,74 5 imaging/diagnostic,^{12,23,46,55,72} 5 meta-analysis/systematic review,^{27,30,66,73,80} 5 technique/review,^{4,26,45,54,62} and 1 survey.⁴⁸

The mean ± SD mCMS was 53 ± 7.2 (range, 39-68). The mean ± SD modified Jadad scale was 3.2 ± 1.1 (range, 2-6). The mean ± SD MINORS was 11.2 ± 3.2 (range, 6-20). There was a significant, strong correlation between rank of mean citations and the modified Jadad scale (r _S = 0.76; P < .0001), demonstrating a trend of poorer modified Jadad scores associated with better ranks or larger mean number of citations. The modified Jadad score was not significantly associated with citation density, however (P = .67). Neither the mCMS nor the MINORS criteria had significant correlation with rank of mean citations or citation density.

Rank and citation density had a weak correlation, with better rank associated with greater citation density (r _S = −0.39; P = .0055). There was a moderate, significant association between year of publication and level of evidence, with more recent years being associated with improved level of evidence (r _S = −0.45; P = .0030). Citation density and year of publication also had a moderate, significant association, with more recent years having greater citation density (r _S = 0.59; P < .001). There was a significant difference in average citations by level of evidence group (P = .043) but no significant difference in citation density by level of evidence group (P = .19).

Tables 1 and 2 demonstrate the Spearman correlation coefficients for number of citations and citation density, respectively.

Table 1

Spearman Correlations Between Citations (Rank) and Level of Evidence and Methodologic Quality Assessments ^a

Correlate with Rank of Mean No. of Citations	No. of Observations	Spearman Coefficient (r _S)	P
Year of publication	50	0.46	.0008
Level of evidence	42	−0.25	.10
mCMS	18	0.15	.56
Modified Jadad scale	27	0.76	<.0001
MINORS	27	0.12	.54

^a Bolded P values indicate statistical significance (P < .05, 2-tailed). mCMS, modified Coleman Methodology Score; MINORS, Methodological Index for Non-Randomized Studies

Table 2

Spearman Correlations Between Number of Citation Density and Level of Evidence and Methodologic Quality Assessments ^a

Correlate With Citation Density ^b	No. of Observations	Spearman Coefficient (r _S)	P
Year of publication	50	0.59	<.0001
Level of evidence	42	−0.23	.15
mCMS	18	0.18	.47
Modified Jadad scale	27	−0.09	.67
MINORS	27	0.06	.76

^a Bolded P value indicates statistical significance (P < .05; 2-tailed). mCMS, modified Coleman Methodology Score; MINORS, Methodological Index for Non-Randomized Studies.

^b Measured as citations per year.

The top 10 articles ranked by citation density between 2010 and 2019 are noted in Table 3.^‡ There was no significant difference in the mean citation density of these recent top 10 articles (18.9 ± 4.0; range, 13.6-25.8) compared with that for the top 10 citations from the overall top 50 list (18.3 ± 4.3; range, 13.4-25.8) (P = .82). Only 3 new articles were introduced by evaluating the recent 10 years ranked by citation density.^10,29,41 The top cited articles from each year between 2010 and 2019 are highlighted in Table 4.^§

Table 3

Ten Most Cited Articles by Approximate Citation Density Between 2010 and 2019

Rank	Lead Author (Year)	Mean No. of Citations	Citation Density ^a
1	Dodwell (2014)^22b	155	25.8
2	Anderson (2015)^5b	115.5	23.1
3	Werner (2016)^83b	84	21
4	Dekker (2017)^21b	63	21
5	Gagliardi (2019)²⁹	20	20
6	Lawrence (2011)^53b	167.5	18.6
7	Ramski (2014)^73b	95.5	15.9
8	Kay (2018)⁴¹	31	15.5
9	Beck (2017)¹⁰	44.5	14.8
10	Frosch (2010)^27b	136	13.6

^a Measured as citations per year.

^b This article was also included in the overall top 50 list generated by total citations.

Table 4

Individual Top Cited Article From Each Year Between 2010 and 2019

Year	Lead Author	Mean No. of Citations	Citation Density ^a
2010	Frosch^27b,c	136	13.6
2011	Lawrence^53b,c	167.5	18.6
2012	Dumont^24b	107.5	13.4
2013	Hägglund^33b	68	9.7
2014	Dodwell^22b,c	155	25.8
2015	Anderson^5b,c	115.5	23.1
2016	Werner^83b,c	84	21
2017	Dekker^21b,c	63	21
2018	Kay^41c	31	15.5
2019	Gagliardi^29c	20	20

^a Measured as citations per year.

^b This article was also included in the overall top 50 list generated by total citations.

^c This article was in the top 10 articles between 2010 and 2019 when sorted by citation density.

Discussion

The present study identified the 50 top cited articles on pediatric and adolescent ACL injuries and reconstruction. The majority of these studies were of low-level evidence, with no studies included that were deemed level 1 evidence. Furthermore, there were no significant correlations between higher methodologic quality and number of citations or citation density. In fact, a better or higher modified Jadad score was associated with worse ranking of mean citations.

Previous investigations^31,81,82 have evaluated bibliometrics relating to ACL injuries. Vielgut et al⁸¹ and Voleti et al⁸² each identified the top 50 most cited articles in ACL research, while Goljan et al³¹ identified the 30 most cited articles in the 20 years before publication. Although the search method varied among these articles, none specifically looked at pediatric and adolescent ACL injuries. Furthermore, none of the titles of the top-cited articles in these previous papers were directly related to pediatric ACL pathologies specifically, and none of the titles in those studies overlapped with those included in the present study. The search method utilized to generate these lists utilized specifically a title search; it is possible that articles that focus on care of younger patients would not be captured using our search terms in the title. However, it appears that overall, management of pediatric and adolescent ACL injuries has been examined less frequently than has management of ACL injuries in adults have been.

While the initial database search yielded 463 results using Web of Science and 478 using Scopus (average 470.5), removing the terms “pediatric,” “adolescent,” and “skeletally immature” from the search to search for (anterior cruciate ligament) OR (ACL) yielded 20,355 results using Web of Science and 18,275 using Scopus (average 19,315). Therefore, approximately only 2.4% of the articles on ACL using these unfiltered search means were related to pediatric or adolescent patients. Several studies^15,35,60,79 have demonstrated an increasing rate of ACL reconstruction particularly in children and adolescents in recent years, especially in the early 2000s, and soon, an increased proportion of studies in this population may be expected with more data available.

Interestingly, 80% of the articles in the top 50 total average citations list were published after the year 2000, and only 2 were published in the 1980s. An increased rate of older articles would typically be expected in a bibliometric analysis like this given that there has been more time to cite articles, articles may have been cited for historical effect, and a “snowball” effect can occur.⁵¹ This bias was evident in this data set where a better rank (ie, more citations) was correlated moderately with earlier year of publication. Several studies^1,37,65 on the natural history and prognosis of management of ACL tears in this population were published in the 1990s and early 2000s, and a plurality of the articles included were prognostic in nature. When examining the top 10 between 2010 and 2019 by citation density, only 3 new articles^10,29,41 were introduced. However, the moderate correlation between greater citation density and later year of publication demonstrates that more contemporary studies have had a stronger and immediate influence in recent years. The relative recency of included articles highlights the youth of pediatric sports medicine as a field, particularly with respect to ACL tears. Previous examination of the top 100 articles in pediatric orthopaedics as a whole demonstrated that 65% of the articles were published in the 1980s or earlier.⁴⁰ Furthermore, none of the articles in the present study was noted in other previous studies on the top articles in pediatric orthopaedics.^9,40

Although the topics included were vast, there were relatively few basic science--related studies, with only 1 animal study⁶⁹ and 2 biomechanical studies^11,43 included. This is a smaller proportion (6%) than those previously cited in top articles in ACL injuries in general, with 1 study citing 42% basic science⁸²; 1 study, 26.7%³¹; and 1 study, 36%.⁸¹ The present study included articles specific to pediatrics, and it is possible that animal and biomechanical studies include principles that can be applied to both pediatric and adult patients and that therefore fewer of these studies would be captured using the current methodology.

Furthermore, there were no included level 1 studies; the top-cited study⁴⁸ was expert opinion (level 5 evidence); and the majority were level 4 evidence, with the most common study type being case series. In pediatric orthopaedics, it has been previously shown that most articles are level 4 evidence, with a significantly greater proportion of level 1 studies in adult-based orthopaedic journals.^16,67 The lower-level evidence in pediatric orthopaedics may be expected given the ethical and institutional barriers faced in enrolling pediatric patients in clinical trials and blinding and randomizing treatments. As such, the lack of correlation between top-cited articles and higher methodologic quality is also not surprising. A higher modified Jadad scale score was significantly associated with worse rank (ie, closer to rank 50 or cited fewer times) on the list, which is a relationship in the opposite direction than may be desirable. The ability to draw conclusions on the true effect of the modified Jadad scale utilized may, however, be limited further by the narrow range of this scoring system. It is reassuring that there was a moderate association between later publication year and stronger level of evidence, suggesting improving level of evidence studies over time. More recent comparison studies among outcomes of various pediatric reconstruction techniques may have higher level of evidence and methodologic quality and may be expected to have larger numbers of citations in the future. Furthermore, additional recent topics of interest such as bridge-enhanced ACL repair⁶⁸ may be better captured in similar lists in future years. Ultimately, evaluation of trends of popular articles, including their topics and study types, can guide future directions in research to areas of interest or to topics less studied.

Several limitations exist with this style of study. The selected number of most cited 50 articles was arbitrary, and many influential and groundbreaking studies exist outside of this top 50 list. There is an inherent bias toward to earlier-published studies because of longer time to cite and the possibility of a snowball effect.⁵¹ Therefore, some older studies may have less current clinical relevance. Although citation density in recent years was also examined in this study, another way to measure the immediate and short-term influence of studies could be to evaluate citation density in the first 5 to 10 years after year of publication. The number of citations is also in flux, and the list may change further over time. Different search techniques and methods may have yielded different included articles. Although there were no significant correlations with higher methodologic quality, these findings do not imply that the studies were poorly performed; particularly in pediatric orthopaedics, study designs may be limited by external ethical and institutional factors. Furthermore, many studies included were not assessed for methodologic quality.

Conclusion

Influential articles on pediatric and adolescent ACL injuries were relatively recent with a low proportion of basic science–type articles. Most studies were lower-level evidence with poor methodologic quality scores. Higher methodologic quality does not correlate positively with citation data.

Footnotes

Final revision submitted September 22, 2020; accepted February 9, 2021.

One or more of the authors has declared the following potential conflict of interest or source of funding: D.A.L. has received research and education payments from Arthrex and Smith & Nephew, education payments from Medwest, and hospitality payments from Wright Medical. N.K.P. has received consulting fees from OrthoPediatrics and education payments from Evolution Surgical. B.T.F. has received consulting fees from Kalibur and education payments from Zimmer Biomet. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

Notes

APPENDIX

Table A1

Top 50 Most Cited Articles Pertaining to Pediatric and Adolescent Anterior Cruciate Ligament Reconstruction

Rank	Lead Author (Year)	Country	Study Type	Mean No. of Citations	Citation Density ^b	LOE	mCMS	Modified Jadad Scale	MINORS Score
1	Kocher (2002)⁴⁸	USA	Survey	288.5	16.0	5	N/A	N/A	N/A
2	Aichroth (2002)¹	UK	Cohort study	259	14.4	2	56	2	14
3	Millett (2002)⁶⁴	USA	Case series	231.5	12.9	4	43	2	10
4	Lipscomb (1986)⁵⁶	USA	Case series	229	6.7	4	46	2	10
5	Graf (1992)³²	USA	Case series	227.5	8.1	4	49	2	10
6	Mizuta (1995)⁶⁵	Japan	Case series	214	8.6	4	N/A	2	10
7	Shea (2004)⁷⁴	USA	Descriptive epidemiology	183	11.4	4	N/A	N/A	N/A
8	Kocher (2005)⁴⁴	USA	Case series	181	12.1	4	68	3	8
9	Andrews (1994)⁶	USA	Case series	176	6.8	4	54	2	10
10	Lawrence (2011)⁵³	USA	Cohort study	167.5	18.6	3	N/A	3	17
11	Anderson (2003)³	USA	Case series	166	9.8	4	57	2	10
12	Koman (1999)⁵⁰	USA	Case report	155.5	7.4	5	N/A	N/A	N/A
13	Dodwell (2014)²²	USA	Descriptive epidemiology	155	25.8	4	N/A	N/A	N/A
14	Lo (1997)⁵⁷	USA	Case series	147	6.4	4	50	2	10
15	Kocher (2007)⁴⁹	USA	Case series	146.5	11.3	4	59	3	9
16	Frosch (2010)²⁷	Germany	Meta-analysis/systematic review	136	13.6	4	N/A	N/A	N/A
17	Janarv (1996)³⁷	Sweden	Case series	123	5.1	4	47	4	10
18	Angel (1989)⁷	Australia	Case series	121.5	3.9	4	N/A	3	10
19	Anderson (2015)⁵	USA	Cohort study	115.5	23.1	3	N/A	4	10
20	Dumont (2012)²⁴	USA	Cross-sectional	107.5	13.4	3	N/A	N/A	N/A
21	Lee (1999)⁵⁵	USA	Imaging/diagnostic	102.5	4.9	4	N/A	N/A	N/A
22	Aronowitz (2000)⁸	USA	Case series	101	5.1	4	49	3	9
23	Ramski (2014)⁷³	USA	Meta-analysis/systematic review	95.5	15.9	3	N/A	N/A	N/A
24	Lawrence (2010)⁵⁴	USA	Technique/review	95	9.5	N/A	N/A	N/A	N/A
25	Anderson (2004)⁴	USA	Technique/review	94	5.9	N/A	N/A	N/A	N/A
26	Kocher (2002)⁴⁷	USA	Cohort study	93.5	5.2	2	N/A	4	12
27	Vavken (2011)⁸⁰	USA	Meta-analysis/systematic review	92.5	10.3	4	N/A	N/A	N/A
28	Woods (2004)⁸⁵	USA	Case-control	89.5	5.6	3	N/A	3	10
29	Fabricant (2013)²⁶	USA	Technique/review	89	12.7	N/A	N/A	N/A	N/A
30	Murray (2009)⁶⁹	USA	Animal study	88	8.0	N/A	N/A	N/A	N/A
31	Werner (2016)⁸³	USA	Cohort study	84	21.0	3	N/A	3	19
32	McIntosh (2006)⁶³	USA	Case series	82.5	5.9	4	54	4	10
33	Fuchs (2002)²⁸	USA	Case series	80.5	4.5	4	52	3	11
34	Karageanes (2000)³⁹	USA	Case series	78.5	3.9	4	N/A	6	13
35	Kocher (2006)⁴⁵	USA	Technique/review	78	5.6	N/A	N/A	N/A	N/A
36	Steadman (2006)⁷⁸	USA	Case series	75.5	5.4	4	54	3	10
37	Domzalski (2010)²³	Poland	Imaging/diagnostic	75	7.5	3	N/A	N/A	N/A
38	Behr (2001)¹¹	USA	Biomechanical/cadaveric	72.5	3.8	N/A	N/A	N/A	N/A
39	Engelman (2014)²⁵	USA	Case-control	71	11.8	3	59	4	14
40	Prince (2005)⁷²	USA	Imaging/diagnostic	69	4.6	4	N/A	N/A	N/A
41	Mohtadi (2006)⁶⁶	Canada	Meta-analysis/systematic review	68.5	4.9	4	N/A	N/A	N/A
42	Hägglund (2013)³³	Sweden	Cohort study	68	9.7	2	N/A	6	20
43	Matava (1997)⁶¹	USA	Case series	66.5	2.9	4	54	3	10
44	Kocher (2004)⁴⁶	USA	Imaging/diagnostic	66	4.1	3	N/A	N/A	N/A
45	McCarthy (2012)⁶²	USA	Technique/review	64.5	8.1	N/A	N/A	N/A	N/A
46	Gagnier (2013)³⁰	USA	Meta-analysis/systematic review	63	9.0	3	N/A	N/A	N/A
47	Dekker (2017)²¹	USA	Case series	63	21.0	4	39	4	6
48	Kumar (2013)⁵²	UK	Case series	60.5	8.6	4	64	4	10
49	Kennedy (2011)⁴³	USA	Biomechanical/cadaveric	60	6.7	N/A	N/A	N/A	N/A
50	Bickel (2008)¹²	USA	Imaging/diagnostic	58.5	4.9	4	N/A	N/A	N/A

LOE, level of evidence; mCMS, modified Coleman Methodology Score; MINORS, Methodological Index for Non-Randomized Studies; N/A, not available.

^b Measured as citations per year.

References

Aichroth

Patel

Zorrilla

. The natural history and treatment of rupture of the anterior cruciate ligament in children and adolescents: a prospective review. J Bone Joint Surg Br. 2002;84(1):38–41.

Allahabadi

Eftekhari

Feeley

Lansdown

. Influential and highest cited shoulder instability articles: a bibliometric analysis [published online March 26, 2021]. Orthop J Sports Med. doi:10.1177/2325967121992577

Anderson

. Transepiphyseal replacement of the anterior cruciate ligament in skeletally immature patients: a preliminary report. J Bone Joint Surg Am. 2003;85(7):1255–1263.

Anderson

. Transepiphyseal replacement of the anterior cruciate ligament using quadruple hamstring grafts in skeletally immature patients. J Bone Joint Surg Am. 2004;86(suppl 1, pt 2):201–209.

Anderson

. Correlation of meniscal and articular cartilage injuries in children and adolescents with timing of anterior cruciate ligament reconstruction. Am J Sports Med. 2015;43(2):275–281.

Andrews

Noyes

Barber-Westin

. Anterior cruciate ligament allograft reconstruction in the skeletally immature athlete. Am J Sports Med. 1994;22(1):48–54.

Angel

Hall

. Anterior cruciate ligament injury in children and adolescents. Arthroscopy. 1989;5(3):197–200.

Aronowitz

Ganley

Goode

Gregg

Meyer

. Anterior cruciate ligament reconstruction in adolescents with open physes. Am J Sports Med. 2000;28(2):168–175.

Baldwin

Kovatch

Namdari

Sankar

Flynn

Dormans

. The 50 most cited articles in pediatric orthopedic surgery. J Pediatr Orthop B. 2012;21(5):463–468.

10.

Beck

Lawrence

JTR

Nordin

DeFor

Tompkins

. ACL tears in school-aged children and adolescents over 20 years. Pediatrics. 2017;139(3):e20161877.

11.

Behr

Potter

Paletta

. The relationship of the femoral origin of the anterior cruciate ligament and the distal femoral physeal plate in the skeletally immature knee: an anatomic study. Am J Sports Med. 2001;29(6):781–787.

12.

Bickel

Fowler

Mowbray

Adler

Klingele

Phillips

. Preoperative magnetic resonance imaging cross-sectional area for the measurement of hamstring autograft diameter for reconstruction of the adolescent anterior cruciate ligament. Arthroscopy. 2008;24(12):1336–1341.

13.

Borchers

Pedroza

Kaeding

. Activity level and graft type as risk factors for anterior cruciate ligament graft failure: a case-control study. Am J Sports Med. 2009;37(12):2362–2367.

14.

Bozzo

Oitment

Evaniew

Ghert

. The journal impact factor of orthopaedic journals does not predict individual paper citation rate. J Am Acad Orthop Surg Glob Res Rev. 2017;1(2):e007.

15.

Buller

Best

Baraga

Kaplan

. Trends in anterior cruciate ligament reconstruction in the United States. Orthop J Sports Med. 2015;3(1):2325967114563664.

16.

Cashin

Kelley

Douziech

Varghese

Hamilton

Mulpuri

. The levels of evidence in pediatric orthopaedic journals: where are we now? J Pediatr Orthop. 2011;31(6):721–725.

17.

Cassar Gheiti

Downey

Byrne

Molony

Mulhall

. The 25 most cited articles in arthroscopic orthopaedic surgery. Arthroscopy. 2012;28(4):548–564.

18.

Chen

J-H

Yen

Y-C

Liu

S-H

, et al. Dementia risk in irradiated patients with head and neck cancer: Medicine. 2015;94(45):e1983.

19.

Coleman

Khan

Maffulli

Cook

Wark

. Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports. 2000;10(1):2–11.

20.

Dancey

Reidy

. Statistics Without Maths for Psychology. 7th ed. Pearson; 2017.

21.

Dekker

Godin

Dale

Garrett

Taylor

Riboh

. Return to sport after pediatric anterior cruciate ligament reconstruction and its effect on subsequent anterior cruciate ligament injury. J Bone Joint Surg Am. 2017;99(11):897–904.

22.

Dodwell

Lamont

Green

Pan

Marx

, Lyman S. 20 years of pediatric anterior cruciate ligament reconstruction in New York State. Am J Sports Med. 2014;42(3):675–680.

23.

Domzalski

Grzelak

Gabos

. Risk factors for anterior cruciate ligament injury in skeletally immature patients: analysis of intercondylar notch width using magnetic resonance imaging. Int Orthop. 2010;34(5):703–707.

24.

Dumont

Hogue

Padalecki

Okoro

Wilson

. Meniscal and chondral injuries associated with pediatric anterior cruciate ligament tears: relationship of treatment time and patient-specific factors. Am J Sports Med. 2012;40(9):2128–2133.

25.

Engelman

Carry

Hitt

Polousky

Vidal

. Comparison of allograft versus autograft anterior cruciate ligament reconstruction graft survival in an active adolescent cohort. Am J Sports Med. 2014;42(10):2311–2318.

26.

Fabricant

Jones

Delos

, et al. Reconstruction of the anterior cruciate ligament in the skeletally immature athlete: a review of current concepts. AAOS exhibit selection. J Bone Joint Surg Am. 2013;95(5):e28.

27.

Frosch

K-H

Stengel

Brodhun

, et al. Outcomes and risks of operative treatment of rupture of the anterior cruciate ligament in children and adolescents. Arthroscopy. 2010;26(11):1539–1550.

28.

Fuchs

Wheatley

Uribe

Hechtman

Zvijac

Schurhoff

. Intra-articular anterior cruciate ligament reconstruction using patellar tendon allograft in the skeletally immature patient. Arthroscopy. 2002;18(8):824–828.

29.

Gagliardi

Carry

Parikh

Traver

Howell

Albright

. ACL repair with suture ligament augmentation is associated with a high failure rate among adolescent patients. Am J Sports Med. 2019;47(3):560–566.

30.

Gagnier

Morgenstern

Chess

. Interventions designed to prevent anterior cruciate ligament injuries in adolescents and adults: a systematic review and meta-analysis. Am J Sports Med. 2013;41(8):1952–1962.

31.

Goljan

Kurowicki

Pierce

, et al. The most cited original articles on anterior cruciate ligament injuries in the past 20 years. J Long Term Eff Med Implants. 2018;28(3):247–257.

32.

Graf

Lange

Fujisaki

Landry

Saluja

. Anterior cruciate ligament tears in skeletally immature patients: meniscal pathology at presentation and after attempted conservative treatment. Arthroscopy. 1992;8(2):229–233.

33.

Hägglund

Atroshi

Wagner

Waldén

. Superior compliance with a neuromuscular training programme is associated with fewer ACL injuries and fewer acute knee injuries in female adolescent football players: secondary analysis of an RCT. Br J Sports Med. 2013;47(15):974–979.

34.

Henry

Chotel

Chouteau

Fessy

Bérard

Moyen

. Rupture of the anterior cruciate ligament in children: early reconstruction with open physes or delayed reconstruction to skeletal maturity? Knee Surg Sports Traumatol Arthrosc. 2009;17(7):748–755.

35.

Herzog

Marshall

Lund

Pate

Mack

Spang

. Trends in incidence of ACL reconstruction and concomitant procedures among commercially insured individuals in the United States, 2002-2014. Sports Health. 2018;10(6):523–531.

36.

Jadad

Moore

Carroll

, et al.

Assessing the quality of reports of randomized clinical trials: is blinding necessary?

Control Clin Trials. 1996;17(1):1–12.

37.

Janarv

Nyström

Werner

Hirsch

. Anterior cruciate ligament injuries in skeletally immature patients. J Pediatr Orthop. 1996;16(5):673–677.

38.

Kaeding

Pedroza

Reinke

Huston

; MOON Consortium, Spindler

. Risk factors and predictors of subsequent ACL injury in either knee after ACL reconstruction: prospective analysis of 2488 primary ACL reconstructions from the MOON cohort. Am J Sports Med. 2015;43(7):1583–1590.

39.

Karageanes

Blackburn

Vangelos

. The association of the menstrual cycle with the laxity of the anterior cruciate ligament in adolescent female athletes. Clin J Sport Med. 2000;10(3):162–168.

40.

Kavanagh

Kelly

Moore

. The 100 classic papers of pediatric orthopaedic surgery: a bibliometric analysis. J Bone Joint Surg Am. 2013;95(18):e134.

41.

Kay

Memon

Marx

Peterson

Simunovic

Ayeni

. Over 90% of children and adolescents return to sport after anterior cruciate ligament reconstruction: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2018;26(4):1019–1036.

42.

Kelly

Glynn

O’Briain

Felle

McCabe

. The 100 classic papers of orthopaedic surgery: a bibliometric analysis. J Bone Joint Surg Br. 2010;92(10):1338–1343.

43.

Kennedy

Coughlin

Metzger

, et al. Biomechanical evaluation of pediatric anterior cruciate ligament reconstruction techniques. Am J Sports Med. 2011;39(5):964–971.

44.

Kocher

Garg

Micheli

. Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. J Bone Joint Surg Am. 2005;87(11):2371–2379.

45.

Kocher

Garg

Micheli

. Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents: surgical technique. J Bone Joint Surg Am. 2006;88(suppl 1, pt 2):283–293.

46.

Kocher

Mandiga

Klingele

Bley

Micheli

. Anterior cruciate ligament injury versus tibial spine fracture in the skeletally immature knee: a comparison of skeletal maturation and notch width index. J Pediatr Orthop. 2004;24(2):185–188.

47.

Kocher

Micheli

Zurakowski

Luke

. Partial tears of the anterior cruciate ligament in children and adolescents. Am J Sports Med. 2002;30(5):697–703.

48.

Kocher

Saxon

Hovis

Hawkins

. Management and complications of anterior cruciate ligament injuries in skeletally immature patients: survey of the Herodicus Society and the ACL Study Group. J Pediatr Orthop. 2002;22(4):452–457.

49.

Kocher

Smith

Zoric

Lee

Micheli

. Transphyseal anterior cruciate ligament reconstruction in skeletally immature pubescent adolescents. J Bone Joint Surg Am. 2007;89(12):2632–2639.

50.

Koman

Sanders

. Valgus deformity after reconstruction of the anterior cruciate ligament in a skeletally immature patient: a case report. J Bone Joint Surg Am. 1999;81(5):711–715.

51.

Kuhn

. Historical structure of scientific discovery. Science. 1962;136(3518):760–764.

52.

Kumar

Ahearne

Hunt

. Transphyseal anterior cruciate ligament reconstruction in the skeletally immature: follow-up to a minimum of sixteen years of age. J Bone Joint Surg Am. 2013;95(1):e1.

53.

Lawrence

JTR

Argawal

Ganley

. Degeneration of the knee joint in skeletally immature patients with a diagnosis of an anterior cruciate ligament tear: is there harm in delay of treatment? Am J Sports Med. 2011;39(12):2582–2587.

54.

Lawrence

JTR

Bowers

Belding

Cody

Ganley

. All-epiphyseal anterior cruciate ligament reconstruction in skeletally immature patients. Clin Orthop Relat Res. 2010;468(7):1971–1977.

55.

Lee

Siegel

Lau

Hildebolt

Matava

. Anterior cruciate ligament tears: MR imaging-based diagnosis in a pediatric population. Radiology. 1999;213(3):697–704.

56.

Lipscomb

Anderson

. Tears of the anterior cruciate ligament in adolescents. J Bone Joint Surg Am. 1986;68(1):19–28.

57.

Kirkley

Fowler

Miniaci

. The outcome of operatively treated anterior cruciate ligament disruptions in the skeletally immature child. Arthroscopy. 1997;13(5):627–634.

58.

Longo

Rizzello

Loppini

, et al. Multidirectional instability of the shoulder: a systematic review. Arthroscopy. 2015;31(12):2431–2443.

59.

Lum

Pereira

Giordani

Meehan

. Top 100 most cited articles in orthopaedic surgery: an update. J Orthop. 2020;19:132–137.

60.

Mall

Chalmers

Moric

, et al. Incidence and trends of anterior cruciate ligament reconstruction in the United States. Am J Sports Med. 2014;42(10):2363–2370.

61.

Matava

Siegel

. Arthroscopic reconstruction of the ACL with semitendinosus-gracilis autograft in skeletally immature adolescent patients. Am J Knee Surg. 1997;10(2):60–69.

62.

McCarthy

Graziano

Green

Cordasco

. All-epiphyseal, all-inside anterior cruciate ligament reconstruction technique for skeletally immature patients. Arthrosc Tech. 2012;1(2):e231–e239.

63.

McIntosh

Dahm

Stuart

. Anterior cruciate ligament reconstruction in the skeletally immature patient. Arthroscopy. 2006;22(12):1325–1330.

64.

Millett

Willis

Warren

. Associated injuries in pediatric and adolescent anterior cruciate ligament tears: does a delay in treatment increase the risk of meniscal tear? Arthroscopy. 2002;18(9):955–959.

65.

Mizuta

Kubota

Shiraishi

Otsuka

Nagamoto

Takagi

. The conservative treatment of complete tears of the anterior cruciate ligament in skeletally immature patients. J Bone Joint Surg Br. 1995;77(6):890–894.

66.

Mohtadi

Grant

. Managing anterior cruciate ligament deficiency in the skeletally immature individual: a systematic review of the literature. Clin J Sport Med. 2006;16(6):457–464.

67.

Murphy

Cibulas

Sawyer

Spence

Kelly

. Levels of evidence in the Journal of Pediatric Orthopaedics: update and comparison to the Journal of Bone and Joint Surgery . J Pediatr Orthop. 2015;35(7):779–781.

68.

Murray

Kalish

Fleming

, et al. Bridge-enhanced anterior cruciate ligament repair: two-year results of a first-in-human study. Orthop J Sports Med. 2019;7(3):2325967118824356.

69.

Murray

Palmer

Abreu

Spindler

Zurakowski

Fleming

. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res. 2009;27(5):639–645.

70.

Newman

Carry

Terhune

, et al. Factors predictive of concomitant injuries among children and adolescents undergoing anterior cruciate ligament surgery. Am J Sports Med. 2015;43(2):282–288.

71.

Pinski

Boakye

Murawski

Hannon

Ross

Kennedy

. Low level of evidence and methodologic quality of clinical outcome studies on cartilage repair of the ankle. Arthroscopy. 2016;32(1):214–222.

72.

Prince

Laor

Bean

. MRI of anterior cruciate ligament injuries and associated findings in the pediatric knee: changes with skeletal maturation. AJR Am J Roentgenol. 2005;185(3):756–762.

73.

Ramski

Kanj

Franklin

Baldwin

Ganley

. Anterior cruciate ligament tears in children and adolescents: a meta-analysis of nonoperative versus operative treatment. Am J Sports Med. 2014;42(11):2769–2776.

74.

Shea

Pfeiffer

Wang

Curtin

Apel

. Anterior cruciate ligament injury in pediatric and adolescent soccer players: an analysis of insurance data. J Pediatr Orthop. 2004;24(6):623–628.

75.

Shen

Zhang

, et al. Utility of gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage in premenopausal women with breast cancer: a systematic review and meta-analysis. Onco Targets Ther. 2015;8:3349–3359.

76.

Slim

Nini

Forestier

Kwiatkowski

Panis

Chipponi

. Methodological Index for Non-Randomized Studies (minors): development and validation of a new instrument. ANZ J Surg. 2003;73(9):712–716.

77.

Sochacki

Jack

Nauert

Harris

. Correlation between quality of evidence and number of citations in top 50 cited articles in rotator cuff repair surgery. Orthop J Sports Med. 2018;6(6):2325967118776635.

78.

Steadman

Cameron-Donaldson

Briggs

Rodkey

. A minimally invasive technique (“healing response”) to treat proximal ACL injuries in skeletally immature athletes. J Knee Surg. 2006;19(1):8–13.

79.

Tepolt

Feldman

Kocher

. Trends in pediatric ACL reconstruction from the PHIS database. J Pediatr Orthop. 2018;38(9):e490–e494.

80.

Vavken

Murray

. Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy. 2011;27(5):704–716.

81.

Vielgut

Dauwe

Leithner

Holzer

. The fifty highest cited papers in anterior cruciate ligament injury. Int Orthop. 2017;41(7):1405–1412.

82.

Voleti

Tjoumakaris

Rotmil

Freedman

. Fifty most-cited articles in anterior cruciate ligament research. Orthopedics. 2015;38(4):e297–e304.

83.

Werner

Yang

Looney

Gwathmey

. Trends in pediatric and adolescent anterior cruciate ligament injury and reconstruction. J Pediatr Orthop. 2016;36(5):447–452.

84.

Wong

Feeley

Pandya

. Complications after pediatric ACL reconstruction: a meta-analysis. J Pediatr Orthop. 2019;39(8):e566–e571.

85.

Woods

O’Connor

. Delayed anterior cruciate ligament reconstruction in adolescents with open physes. Am J Sports Med. 2004;32(1):201–210.

86.

Zhang

Zhou

Liu

, et al. The effectiveness of the problem-based learning teaching model for use in introductory Chinese undergraduate medical courses: a systematic review and meta-analysis. PLoS One. 2015;10(3):e0120884.

Influential Articles on Pediatric and Adolescent Anterior Cruciate Ligament Injuries: A Bibliometric Analysis

Abstract

Background:

Purpose:

Study Design:

Methods:

Results:

Conclusion:

Keywords

Methods

Results

Discussion

Conclusion

Footnotes

Notes

APPENDIX

References