Three patients with pachydermoperiostosis are reported. All patients presented with moderate pain and swelling in multiple joints unresponsive to treatment, characteristic facial features which were marked in two cases, clubbing of nails and enlargement of distal parts of the extremities. One patient had spondylolisthesis of L5-S1 vertebrae, an association not previously described in this syndrome. The natural history of the disease is reviewed and the differential diagnosis is discussed.
AmeriMRAlebouyehMDonnerMW. Hypertrophic osteoarthropathy in childhood malignancy: AJR1978, 130:992–3.
2.
JosephBChackoV. Acro-osteolysis with Hypertrophic Pulmonary Osteoarthropathy and Pachydermoperiostosis: Radiology1985, 154:343–4.
3.
GillilandBC. Relapsing Polychondritis and other Arthritides: In: Harrison's Principles of Internal Medicine. Vol 2, 14th ed.Singapore: Mc Graw-Hill Book Co., 1998, 1951–63.
4.
ResnickDNiwayamaG. Enostosis, Hyperostosis, and periostitis: In: Donald Resnick Diagnosis of Bone and Joint disorders.Vol 6, 3rd ed.Philadelphia: W B Saunders, 1995, 4421–27.
5.
FriedreichN. Hyperostose des gesammten skelettes: Virchows Arch Pathol Anat1868; 43:83.
6.
GuyerPBBruntonFJWrenMWG. Pachydermoperiostosis with Acro-osteolysis: J. Bone and Joint Surgery (Br)Vol 60, 1978, 219–23.
7.
HarbisonJ BNiceC MJr. Familial Pachydermoperiostitis presenting as an acromegaly like syndrome: AJR1971, 112:532.
