To investigate the role of leptin hormone and oxidative stress in the
pathogenesis of endometriosis among infertile women.
Methods
Blood samples and peritoneal fluid were collected from women undergoing
laparoscopy. The study group included 24 infertile women with endometriosis,
while 14 women with unexplained infertility represented the control group.
Leptin hormone levels and three markers of antioxidants, including total
antioxidant capacity (TAC), catalase (CAT) enzyme and superoxide dismutase
(SOD) enzyme were estimated.
Results
Peritoneal fluid leptin concentrations were significantly higher in infertile
endometriotic women compared with the control group. The levels of TAC, CAT
and SOD were significantly lower in both serum and peritoneal fluid of
infertile endometriotic women compared with controls. There was no
significant difference in serum leptin concentrations between the studied
groups.
Conclusions
Peritoneal leptin and oxidative stress may be an active factor in the
pathogenesis and/or progression of endometriosis.
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