Previous studies suggest that cognitive control training (CCT) shows potential as a preventive intervention for depression. In this study, the first to examine long-term preventive effects of CCT, we examined effects on (a) task-specific cognitive transfer at 1-year follow-up, (b) recurrence of depression, and (c) functioning over the course of a year. Each of 92 remitted depressed patients were randomly assigned to a CCT condition or an active control condition (ACT). Effects of training were monitored using weekly assessments of emotion regulation, cognitive complaints, depressive symptoms, and resilience (brief weekly questionnaire). At 1-year follow-up, participants completed a structured clinical interview, cognitive transfer task, and questionnaires. We observed task-specific cognitive transfer (p < .001, d = 1.23) and lower recurrence rates in the CCT condition (p = .04; odds ratio = 0.38). However, no long-term beneficial effects of training were observed on the weekly ratings of functioning, and groups did not differ in performance on the self-report questionnaires at 1-year follow-up.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).
2.
BauerM.TharmanathanP.VolzH.-P.MoellerH-J.FreemantleN. (2009). The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression. European Archives of Psychiatry and Clinical Neuroscience, 259(3), 172–185.
3.
BeckA. T.SteerR. A.BrownG. K. (1996). Manual for the Beck Depression Inventory-II. Psychological Corporation.
4.
BocktingC. L.HollonS. D.JarrettR. B.KuykenW.DobsonK. (2015). A lifetime approach to major depressive disorder: The contributions of psychological interventions in preventing relapse and recurrence. Clinical Psychology Review, 41, 16–26.
5.
BocktingC. L.KoeterM.ScheneA. (2010). Prediction of recurrence in recurrent depression: A 5.5-year prospective study. The Journal of Clinical Psychiatry, 71(8), 984–991.
6.
BocktingC. L.SpinhovenP.KoeterM. W.WoutersL. F.ScheneA. H. (2006). Prediction of recurrence in recurrent depression and the influence of consecutive episodes on vulnerability for depression: A 2-year prospective study. The Journal of Clinical Psychiatry, 67(5), 747–755.
7.
BosleyH. G.FisherA. J.TaylorC. B. (2018). Differential responses of positive affect, negative affect, and worry in CBT for generalized anxiety disorder: A person-specific analysis of symptom course during therapy. Psychotherapy Research, 28(4), 630–642.
8.
BraverT. S.CohenJ. D.BarchD. M. (2002). The role of the prefrontal cortex in normal and disordered cognitive control: A cognitive neuroscience perspective. Oxford University Press.
9.
BrughaT. S.CraggD. (1990). The list of threatening experiences: The reliability and validity of a brief life events questionnaire. Acta Psychiatrica Scandinavica, 82(1), 77–81.
10.
BrunoniA.BoggioP.De RaedtR.BenseñorI.LotufoP.NamurV.VanderhasseltM.-A. (2014). Cognitive control therapy and transcranial direct current stimulation for depression: A randomized, double-blinded, controlled trial. Journal of Affective Disorders, 162, 43–49.
11.
BuhleJ. T.SilversJ. A.WagerT. D.LopezR.OnyemekwuC.KoberH.OchsnerK. N. (2014). Cognitive reappraisal of emotion: A meta-analysis of human neuroimaging studies. Cerebral Cortex, 24, 2981–2990. https://doi.org/10.1093/cercor/bht154
12.
CalkinsA. W.McMorranK. E.SiegleG. J.OttoM. W. (2015). The effects of computerized cognitive control training on community adults with depressed mood. Behavioural and Cognitive Psychotherapy, 43(5), 578–589.
13.
CohenJ. (2017). Cognitive control: Core constructs and current considerations (The Wiley Handbook of Cognitive Control). John Wiley.
14.
CohenN.MarguliesD. S.AshkenaziS.SchaeferA.TaubertM.HenikA.Okon-SingerH. (2016). Using executive control training to suppress amygdala reactivity to aversive information. NeuroImage, 125, 1022–1031. https://doi.org/10.1016/j.neuroimage.2015.10.069
15.
CoxG. R.FisherC. A.De SilvaS.PhelanM.AkinwaleO. P.SimmonsM. B.HetrickS. E. (2012). Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents. CochraneDatabase of Systematic Reviews, 11, Article CD007504. https://doi.org/10.1002/14651858.CD007504.pub2
16.
CummingG. (2012). Understanding the new statistics: Effect sizes, confidence intervals, and meta-analysis. Routledge
17.
De RaedtR.KosterE. H. W. (2010). Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework. Cognitive Affective & Behavioral Neuroscience, 10, 50–70. https://doi.org/10.3758/cabn.10.1.50
18.
De RaedtR.LeymanL.BaekenC.Van SchuerbeekP.LuypaertR.VanderhasseltM.-A.DannlowksiU. (2010). Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: An event-related fMRI study. Biological Psychology, 85, 487–495. https://doi.org/10.1016/j.biopsycho.2010.09.015
19.
DevillyG. J.BorkovecT. D. (2000). Psychometric properties of the credibility/expectancy questionnaire. Journal of Behavior Therapy and Experimental Psychiatry, 31(2), 73–86.
20.
EkmanM.GranströmO.OmérovS.JacobJ.LandénM. (2013). The societal cost of depression: Evidence from 10,000 Swedish patients in psychiatric care. Journal of Affective Disorders, 150(3), 790–797.
21.
EngelenU.De PeuterS.VictoirA.Van DiestI.Van den BerghO. (2006). Verdere validering van de Positive and Negative Affect Schedule (PANAS) en vergelijking van twee Nederlandstalige versies [Further validation of the Positive and Negative Affect Schedule (PANAS) and comparison of two Dutch versions]. Gedrag en gezondheid, 34(2), 61–70.
22.
FisherA. J.MedagliaJ. D.JeronimusB. F. (2018). Lack of group-to-individual generalizability is a threat to human subjects research. Proceedings of the National Academy of Sciences, USA, 115(27), E6106–E6115.
23.
GarnefskiN.KraaijV.SpinhovenP. (2001). Negative life events, cognitive emotion regulation and emotional problems. Personality and Individual Differences, 30(8), 1311–1327.
24.
GronwallD. (1977). Paced auditory serial-addition task: A measure of recovery from concussion. Perceptual and Motor Skills, 44(2), 367–373.
25.
HofmannW.PatelP. V. (2015). SurveySignal: A convenient solution for experience sampling research using participants’ own smartphones. Social Science Computer Review, 33(2), 235–253.
26.
HoorelbekeK.FaelensL.BehielsJ.KosterE. H. (2015). Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Protocol for a randomized controlled trial. BMC Psychiatry, 15(1), Article 125. https://doi.org/10.1037/ccp0000128
27.
HoorelbekeK.KosterE. H. (2017). Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Evidence from a double-blind randomized controlled trial study. Journal of Consulting and Clinical Psychology, 85(2), 135–146.
28.
HoorelbekeK.KosterE. H.DemeyerI.LoeysT.VanderhasseltM.-A. (2016). Effects of cognitive control training on the dynamics of (mal)adaptive emotion regulation in daily life. Emotion, 16(7), 945–956.
29.
HoorelbekeK.KosterE. H.VanderhasseltM.-A.CallewaertS.DemeyerI. (2015). The influence of cognitive control training on stress reactivity and rumination in response to a lab stressor and naturalistic stress. Behaviour Research and Therapy, 69, 1–10.
30.
HoorelbekeK.Van den BerghN.De RaedtR.WichersM.AlbersC.J.KosterE. H. W. (2021). Regaining control of your emotions? Investigating the mechanisms underlying effects of cognitive control training for remitted depressed patients [Manuscript submitted for publication]. Department of Experimental Clinical and Health Psychology, Ghent University.
31.
HoorelbekeK.Van den BerghN.WichersM.KosterE. H. W. (2019). Between vulnerability and resilience: A network analysis of fluctuations in cognitive risk and protective factors following remission from depression. Behaviour Research and Therapy, 116, 1–9. https://doi.org/10.1016/j.brat.2019.01.007
32.
IacovielloB. M.WuG.AlvarezE.HurykK.CollinsK. A.MurroughJ.W.IosifescuD.V.CharneyD.S. (2014), Cognitive-emotional training as an intervention for major depressive disorder. Depression & Anxiety, 31(8), 699–706. https://doi.org/10.1002/da.22266
33.
JoormannJ.D’AvanzatoC. (2010). Emotion regulation in depression: Examining the role of cognitive processes. Cognition & Emotion, 24, 913–939. https://doi.org/10.1080/02699931003784939
34.
JoormannJ.VanderlindM. W. (2014). Emotion regulation in depression: The role of biased cognition and reduced cognitive control. Clinical Psychological Science, 2, 402–421. https://doi.org/10.1177/2167702614536163
35.
KesslerR. C. (2012). The costs of depression. Psychiatric Clinics, 35(1), 1–14.
36.
KosterE. H.BernsteinA. (2015). Introduction to the special issue on cognitive bias modification: Taking a step back to move forward?Journal of Behavior Therapy and Experimental Psychiatry, 49, 1–4.
37.
KosterE. H.De LissnyderE.DerakshanN.De RaedtR. (2011). Understanding depressive rumination from a cognitive science perspective: The impaired disengagement hypothesis. Clinical Psychology Review, 31, 138–145. https://doi.org/10.1016/j.cpr.2010.08.005
38.
KosterE. H.HoorelbekeK.OnraedtT.OwensM.DerakshanN. (2017). Cognitive control interventions for depression: A systematic review of findings from training studies. Clinical Psychology Review, 53, 79–92.
39.
LakensD. (2013). Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs. Frontiers in Psychology, 4, Article 863. https://doi.org/10.3389/fpsyg.2013.00863
40.
LevensS. M.GotlibI. H. (2015). Updating emotional content in recovered depressed individuals: Evaluating deficits in emotion processing following a depressive episode. Journal of Behavior Therapy and Experimental Psychiatry, 48, 156–163.
41.
MaS. H.TeasdaleJ. D. (2004). Mindfulness-based cognitive therapy for depression: Replication and exploration of differential relapse prevention effects. Journal of Consulting and Clinical Psychology, 72(1), 31–40.
42.
MartinD. M.TengJ. Z.LoT. Y.AlonzoA.GohT.IacovielloB. M.LooC. K. (2018). Clinical pilot study of transcranial direct current stimulation combined with cognitive emotional training for medication resistant depression. Journal of Affective Disorders, 232, 89–95. https://doi.org/10.1016/j.jad.2018.02.021
43.
MillerE. K.CohenJ. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202.
44.
MoberlyN. J.WatkinsE. R. (2008). Ruminative self-focus and negative affect: An experience sampling study. Journal of Abnormal Psychology, 117(2), 314–323.
MoshierS. J.MolokotosE.SteinA. T.OttoM. W. (2015). Assessing the effects of depressed mood and cognitive control training on memory confidence and accuracy following repeated checking. International Journal of Cognitive Therapy, 8, 1–16. https://doi.org/10.1521/ijct_2015_8_02
47.
MoshierS. J.OttoM. W. (2017). Behavioral activation treatment for major depression: A randomized trial of the efficacy of augmentation with cognitive control training. Journal of Affective Disorders, 210, 265–268. https://doi.org/10.1016/j.jad.2017.01.003
48.
MotterJ. N.PimontelM. A.RindskopfD.DevanandD. P.DoraiswamyP. M.SneedJ. R. (2016). Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis. Journal of Affective Disorders, 189, 184–191.
49.
Nolen-HoeksemaS.MorrowJ. (1991). A prospective study of depression and posttraumatic stress symptoms after a natural disaster: The 1989 Loma Prieta Earthquake. Journal of Personality and Social Psychology, 61(1), 115–121.
50.
OrwinR. G.VeveaJ. L. (2009). Evaluating coding decisions. In CooperH.LarryH. V.JeffreyV. C. (Eds.), The handbook of research synthesis and meta-analysis (2nd ed., pp. 177–203). Russell Sage Foundation.
51.
PortzkyM. (2008). RS-nl: Resilience Scale-Nederlandse versie. Harcourt Test Publishers.
52.
RichmondS. J.KedingA.HoverM.GabeR.CrossB.TorgersonD.MacPhersonH. (2015). Feasibility, acceptability and validity of SMS text messaging for measuring change in depression during a randomised controlled trial. BMC Psychiatry, 15(1), Article 68. https://doi.org/10.1186/s12888-015-0456-3
53.
RosenkranzT.TakanoK.WatkinsE. R.EhringT. (2019). Assessing repetitive negative thinking in daily life: Development of an ecological momentary assessment paradigm. PsyArXiv. https://doi.org/10.31234/osf.io/nj73c
54.
RosmalenJ.BosE.De JongeP. (2012). Validation of the Long-term Difficulties Inventory (LDI) and the List of Threatening Experiences (LTE) as measures of stress in epidemiological population-based cohort studies. Psychological Medicine, 42(12), 2599–2608.
55.
SchmiedekF.LovdenM.LindenbergerU. (2014). Younger adults show long-term effects of cognitive training on broad cognitive abilities over 2 years. Developmental Psychology, 50, 2304–2310. https://doi.org/10.1037/a0037388
56.
ScholteE.NoensI. (2011). BRIEF-A Executieve functies gedragsvragenlijst voor volwassenen [BRIEF-A Executive functions behavioral questionnaire for adults]. In RothR. M.IsquithP. K.GioiaG. A. (Eds.), Vragenlijst executieve functies voor volwassenen. Handleiding [Executive functions questionnaire for adults. Instruction manual] (pp. 1–54). Hogrefe Uitgevers.
57.
SchweizerS.HampshireA.DalgleishT. (2011). Extending brain-training to the affective domain: Increasing cognitive and affective executive control through emotional working memory training. PLOS ONE, 6, Article e24372. https://doi.org/10.1371/journal.pone.0024372
58.
SegraveR. A.ArnoldS.HoyK.FitzgeraldP. B. (2014). Concurrent cognitive control training augments the antidepressant efficacy of tDCS: A pilot study. Brain Stimulation, 7(2), 325–331. https://doi.org/10.1016/j.brs.2013.12.008
59.
SemkovskaM.QuinlivanL.O’GradyT.JohnsonR.CollinsA.O’ConnorJ.GloadT. (2019). Cognitive function following a major depressive episode: A systematic review and meta-analysis. The Lancet Psychiatry, 6, 851–861. https://doi.org/10.1016/S2215-0366(19)30291-3
60.
SheehanD. V.LecrubierY.SheehanK. H.AmorimP.JanavsJ.WeillerE.DunbarG. C. (1998). The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 59, 22–33.
61.
ShipsteadZ.RedickT. S.EngleR. W. (2012). Is working memory training effective?Psychological Bulletin, 138(4), 628–654. https://doi.org/10.1037/a0027473
62.
SiegleG. J.GhinassiF.ThaseM. E. (2007). Neurobehavioral therapies in the 21st century: Summary of an emerging field and an extended example of cognitive control training for depression. Cognitive Therapy and Research, 31(2), 235–262.
63.
SiegleG. J.PriceR. B.JonesN. P.GhinassiF.PainterT.ThaseM. E. (2014). You gotta work at it: Pupillary indices of task focus are prognostic for response to a neurocognitive intervention for rumination in depression. Clinical Psychological Science, 2(4), 455–471.
64.
TeasdaleJ. D.SegalZ. V.WilliamsJ. M. G.RidgewayV. A.SoulsbyJ. M.LauM. A. (2000). Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology, 68(4), 615–623.
65.
TombaughT. N. (2006). A comprehensive review of the Paced Auditory Serial Addition Test (PASAT). Archives of Clinical Neuropsychology, 21, 53–76. https://doi.org/10.1016/j.acn.2005.07.006
66.
TreynorW.GonzalezR.Nolen-HoeksemaS. (2003). Rumination reconsidered: A psychometric analysis. Cognitive Therapy and Research, 27(3), 247–259.
67.
Van den BerghN.HoorelbekeK.De RaedtR.KosterE. H. (2018). Remediation of depression-related cognitive impairment: Cognitive control training as treatment augmentation. Expert Review of Neurotherapeutics, 18(12), 907–913.
68.
Van der DoesA. (2002). BDI-II-NL. Handleiding. De Nederlandse versie van de Beck depression inventory [BDI-II-NL. Instruction manual. The Dutch version of the Beck depression inventory]. Harcourt Test Publishers.
69.
VanderhasseltM.-A.De RaedtR.NamurV.LotufoP. A.BensenorI. M.BoggioP. S.BrunoniA. R. (2015). Transcranial electric stimulation and neurocognitive training in clinically depressed patients: A pilot study of the effects on rumination. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 57, 93–99.
70.
Van VlietI.De BeursE. (2007). The MINI-International Neuropsychiatric Interview. A brief structured diagnostic psychiatric interview for DSM-IV en ICD-10 psychiatric disorders. Tijdschrift voor psychiatrie, 49(6), 393–397.
71.
VervaekeJ.HoorelbekeK.BaekenC.KosterE. H. W. (2021). Online cognitive control training for remitted depressed individuals: A replication and extension study. [Manuscript submitted for publication.] Department of Experimental Clinical and Health Psychology, Ghent University.
72.
VervaekeJ.HoorelbekeK.BaekenC.Van LooyJ.KosterE. H. W. (2020). Transfer and motivation after cognitive control training for remitted depression in healthy sample. Journal of Cognitive Enhancement, 4, 49–61.
73.
WagnildG.YoungH. (1993). Development and psychometric evaluation of the Resilience Scale. Journal of Nursing Measurement, 1(2), 165–178.
74.
WagnildR. N. (2009). A review of the Resilience Scale. Journal of Nursing Measurement, 17, 105–113.
75.
WanmakerS.GeraertsE.FrankenI. H. (2015). A working memory training to decrease rumination in depressed and anxious individuals: A double-blind randomized controlled trial. Journal of Affective Disorders, 175, 310–319. https://doi.org/10.1016/j.jad.2014.12.027
76.
WatkinsE. R.RobertsH. (2020). Reflecting on rumination: Consequences, causes, mechanisms and treatment of rumination. Behaviour Research and Therapy, 127, Article 103573. https://doi.org/10.1016/j.brat.2020.103573
77.
WatsonD.ClarkL. A.TellegenA. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063–1070.
78.
WeightmanM. J.KnightM. J.BauneB. T. (2019). A systematic review of the impact of social cognitive deficits on psychosocial functioning in major depressive disorder and opportunities for therapeutic intervention. Psychiatry Research, 274, 195–212.
79.
WeissmanM. M.PrusoffB. A.KlermanG. L. (1978). Personality and the prediction of long-term outcome of depression. The American Journal of Psychiatry, 135(7), 797–800.
80.
WilkinsonA. J.YangL. (2016). Long-term maintenance of inhibition training effects in older adults: 1- and 3-year follow-up. The Journals of Gerontology: Series B, 71, 622–629. https://doi.org/10.1093/geronb/gbu179
81.
ZimmermanM.MartinezJ. H.AttiullahN.FriedmanM.TobaC.BoerescuD. A.RaghebM. (2013a). A new type of scale for determining remission from depression: The remission from depression questionnaire. Journal of Psychiatric Research, 47(1), 78–82.
82.
ZimmermanM.MartinezJ. H.AttiullahN.FriedmanM.TobaC.BoerescuD. A.RaghebM. V.(2013b). [Dutch translation of Remission from Depression Questionnaire] (PeetersF.NicolsonN.WichersM.HackerP., Trans.). [Unpublished instrument]. Department of Psychiatry and Psychology, Maastricht University. (Original work published 2013.)
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