Recent data show shifts in genetic and environmental influences on emotional eating across the menstrual cycle, with significant shared environmental influences during pre-ovulation and primarily genetic effects during post-ovulation. Factors driving differential effects are unknown, although increased estradiol during pre-ovulation and increased progesterone during post-ovulation are thought to play a role. We indirectly investigated this possibility by examining whether overall levels of estradiol and progesterone differentially impact genetic and environmental risk for emotional eating in adult female twins (N = 571) drawn from the Michigan State University Twin Registry. Emotional eating, estradiol levels, and progesterone levels were assessed daily and then averaged to create aggregate measures for analysis. As predicted, shared environmental influences were significantly greater in twins with high estradiol levels, whereas additive genetic effects increased substantially across low versus high progesterone groups. Results highlight significant and differential effects of ovarian hormones on etiologic risk for emotional eating in adulthood.
AkaikeH. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332.
2.
ArboB. D.AndradeS.OsterkampG.GomezR.RibeiroM. F. (2014). Asymmetric effects of low doses of progesterone on GABA (A) receptor α4 subunit protein expression in the olfactory bulb of female rats. Canadian Journal of Physiology and Pharmacology, 92, 1045–1049.
3.
AsarianL.GearyN. (2013). Sex differences in the physiology of eating. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology, 305, R1215–R1267. doi:10.1152/ajpregu.00446.02012
4.
BeckerJ. B. (2009). Sexual differentiation of motivation: A novel mechanism?Hormones and Behavior, 55, 646–654.
5.
BetheaC. L.CentenoM. L. (2008). Ovarian steroid treatment decreases corticotropin-relesasing hormone (CRH) mRNA and protein in the hypothalamic paraventricular nucleus of ovariectomized monkeys. Neuropsychopharmacology, 33, 546–556.
6.
BetheaC. L.ReddyA. P. (2015). Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Molecular Psychiatry, 20, 1565–1578.
7.
BurtS. A.KlahrA.NealeM.KlumpK. L. (2013). Maternal warmth and directiveness jointly moderate the etiology of conduct problems. Journal of Child Psychology and Psychiatry, 54, 1030–1037.
8.
BurtS. A.KlumpK. L. (2013). The Michigan State University Twin Registry (MSUTR): An update. Twin Research and Human Genetics, 16, 344–350.
9.
CraftR. M. (2008). Sex differences in analgesic, reinforcing, discriminative, and motoric effects of opioids. Experimental and Clinical Psychopharmacology, 16, 376–385.
10.
CulbertK. M.BurtS. A.McGueM.IaconoW. G.KlumpK. L. (2009). Puberty and the genetic diathesis of disordered eating attitudes and behaviors. Journal of Abnormal Psychology, 118, 788–796.
11.
DeaverC. M.MiltenbergerR. G.SymthJ.MeidingerA.CrosbyR. (2003). An evaluation of affect and binge eating. Behavior Modification, 27, 578–599.
12.
EdlerC.LipsonS. F.KeelP. K. (2007). Ovarian hormones and binge eating in bulimia nervosa. Psychological Medicine, 37, 131–141.
13.
GoldschmidtA. B.CrosbyR. D.CaoL.EngelS. G.DurkinN.BeachH. M.. . . PetersonC. B. (2014). Ecological momentary assessment of eating episodes in obese adults. Psychosomatic Medicine, 76, 747–752.
14.
HildebrandtB. A.RacineS. E.KeelP. K.BurtS. A.NealeM.BokerS.. . . KlumpK. L. (2015). The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. International Journal of Eating Disorders, 48, 477–486.
15.
HildebrandtT.AlfanoL.TricamoM.PfaffD. W. (2010). Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clinical Psychology Review, 30, 655–668.
16.
Holm-DenomaJ. M.RicheyJ. A.JoinerT. E. (2010). The latent structure of dietary restraint, body dissatisfaction, and drive for thinness: A series of taxometric analyses. Psychological Assessment, 22, 788–797.
17.
KeelP. K.BrownT. A.HollandL. A.BodellL. P. (2012). Empirical classification of eating diosrders. Annual Review of Clinical Psychology, 8, 381–404.
18.
KlumpK. L. (2013). Puberty as a critical risk period for eating disorders: A review of human and animal studies. Hormones and Behavior, 64, 399–410.
19.
KlumpK. L.BurtS. A. (2006). The Michigan State University Twin Registry (MSUTR): Genetic, environmental and neurobiological influences on behavior across development. Twin Research and Human Genetics, 9, 971–977.
20.
KlumpK. L.BurtS. A.McGueM.IaconoW. G. (2007). Changes in genetic and environmental influences on disordered eating across adolescence: A longitudinal twin study. Archives of General Psychiatry, 64, 1409–1415.
21.
KlumpK. L.CulbertK. M.SlaneJ. D.BurtS. A.SiskC. L.NiggJ. T. (2012). The effects of puberty on genetic risk for disordered eating: Evidence for sex difference. Psychological Medicine, 42, 627–638.
22.
KlumpK. L.HidebrandtB. A.O’ConnorS. M.KeelP. K.NealeM.SiskC. L.. . . BurtS. A. (2015). Changes in genetic risk for emotional eating across the menstrual cycle: A longitudinal study. Psychological Medicine, 45, 3227–3237.
23.
KlumpK. L.KeelP. K.CulbertK. M.EdlerC. (2008). Ovarian hormones and binge eating: Exploring associations in community samples. Psychological Medicine, 38, 1749–1757.
24.
KlumpK. L.KeelP. K.RacineS. E.BurtS. A.NealeM.SiskC. L.. . . HuJ. Y. (2013). The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. Journal of Abnormal Psychology, 122, 131–137.
25.
KlumpK. L.KeelP. K.SiskC. L.BurtS. A. (2010). Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychological Medicine, 40, 1745–1753.
26.
KlumpK. L.McGueM.IaconoW. G. (2003). Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. International Journal of Eating Disorders, 33, 287–292.
27.
KlumpK. L.RacineS. E.HildebrandtB.BurtS. A.NealeM.SiskC. L.. . . KeelP. K. (2014). Ovarian hormone influences on dysregulated eating: A comparison of associations in women with versus without binge episodes. Clinical Psychological Science, 2, 545–559.
28.
KlumpK. L.SuismanJ. L.CulbertK. M.KashyD. A.KeelP. K.SiskC. L. (2011). The effects of ovariectomy on binge eating proneness in adult female rats. Hormones and Behavior, 59, 585–593.
29.
LaghiF.PompiliS.BaumgartnerE.BaioccoR. (2015). The role of sensation seeking and motivations for eating in female and male adolescents who binge eat. Eating Behaviors, 17, 119–124.
30.
LesterN. A.KeelP. K.LipsonS. F. (2003). Symptom fluctuation in bulimia nervosa: Relation to menstrual-cycle phase and cortisol levels. Psychological Medicine, 33, 51–60.
31.
LluchA.HerbertB.MejeanL.SiestG. (2000). Dietary intakes, eating style and overweight in Stanilas Family Study. International journal of Obesity, 24, 1493–1499.
32.
LuN. Z.EshlemanA. J.JanowskyA.BetheaC. L. (2003). Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular Psychiatry, 8, 353–360.
33.
LuoX.DonnellanM. B.BurtS. A.KlumpK. L. (2016). The dimensional nature of eating pathology: Evidence from a direct comparison of categorica, dimensional, and hybrid models. Journal of Abnormal Psychology, 125, 715–726.
34.
McManusF.WallerG. I. (1995). A functional analysis of binge-eating. Clinical Psychology Review, 15, 845–863.
35.
NealeM. C.BokerS. M.XieG.MaesH. H. (1999). Mx: Statistical modeling (5th ed.). Richmond, VA: Department of Psychiatry.
36.
Nguyen-MichelS. T.UngerJ. B.Spruijt-MetzD. (2007). Dietary correlates of emotional eating in adolescence. Appetite, 49, 494–499.
37.
NilssonM.NaessénS.DahlmanI.HirschbergA. L.GustafssonJ. Å.Dahlman-WrightK. (2004). Association of estrogen receptor β gene polymorphisms with bulimic disease in women. Molecular Psychiatry, 9, 28–34.
38.
OlatunjiB. O.Broman-FulksJ. J.CiesielskiB. G.ZawilinskiL. L.ShewmakerS.WallD. (2012). A taxometric investigation of the latent structure of eating disorders. Psychiatry Research, 197, 97–102.
39.
OstlundH.KellerE.HurdY. L. (2003). Estrogen receptor gene expression in relation to neuropsychiatric disorders. Annals of the New York Academy of Sciences, 1007, 54–63.
40.
PurcellS. (2002). Variance components models for gene-environment interaction in twin analysis. Twin Research, 5, 554–571.
41.
QuastC.ReifA.BrücklT.PfisterH.WeberH.MattheisenM.. . . ErhardtA. (2014). Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: Additional evidence for the importance of neurosteroids in anxiety?Depression and Anxiety, 31, 843–850.
42.
RacineS. E.CulbertK. M.LarsonC. L.KlumpK. L. (2009). The possible influences of impulsivity and dietary restraint on associations between serotonin genes and binge eating. Journal of Psychiatric Research, 43, 1278–1286.
43.
RiccaV.CastelliniG.FioravantiG.SauroC. L.RotellaF.RavaldiC.. . . FaravelliC. (2012). Emotional eating in anorexia nervosa and bulimia nervosa. Comprehensive Psychiatry, 53, 245–251.
44.
RiccaV.CastelliniG.SauroC. L.RavaldiC.LapiF.MannucciE.. . . FaravelliC. (2009). Corrrelations between binge eating and emotional eating in a sample of overweight subjects. Appetite, 53, 418–421.
45.
SantolloJ.MarshallA.DanielsD. (2012). Activation of membrane associated estrogen receptors decreases food and water intake in ovariectomized rats. Endocrinology, 154, 320–329.
46.
SchüleC.NothdurfterbC.RupprechtR. (2014). The role of allopregnanolone in depression and anxiety. Progress in Neurobiology, 113, 79–87.
47.
SiskC. L.ZehrJ. L. (2005). Puberty hormones organize the adolescent brain and behavior. Frontiers in Neuroendocrinology, 26, 163–174.
48.
SnoekH. M.Van StrienT.JanssensJ. M.EngelsR. C. (2007). Emotional, external, restrained eating and overweight in Dutch adolescents. Scandinavian Journal of Psychology, 48, 23–32.
49.
SuismanJ. L.ThompsonJ. K.KeelP. K.BurtS. A.NealeM.BokerS.. . . KlumpK. L. (2014). Genetic and environmental influences in thin-ideal internalization across puberty and pre-adolescent, adolescent, and young adult development. International Journal of Eating Disorders, 47, 773–783.
50.
TylkaT. L.SubichL. M. (2003). Revisiting the latent structure of eating disorders: Taxometric analyses with nonbehavioral indicators. Journal of Counseling Psychology, 50, 276.
51.
van der SluisS.PosthumaD.DolanC. V. (2012). A note on false positives and power in GxE modeling of twin data. Behavior Genetics, 42, 170–186.
52.
Van StrienT. (2000). Ice-cream consumption, tendency toward overeating, and personality. Appetite, 52, 380–387.
53.
Van StrienT. (2010). Predicting distress-induced eating with self-reports: Mission impossible or a piece of cake?Health Psychology, 29, 343.
54.
Van StrienT.FrijtersJ. E.BergersG. P.DefaresP. B. (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders, 5, 295–315.
55.
WardleJ. (1987). Eating style: A validation study of the Dutch Eating Behaviour Questionnaire in normal subjects and women with eating disorders. Journal of Psychosomatic Research, 31, 161–169.
56.
WrightA. G. C.KruegerR. F.HobbsM. J.MarkonK. E.EatonN. R.SladeT. (2013). The structure of psychopathology: Toward an expanded quantitative empirical model. Journal of Abnormal Psychology, 122, 281–294.
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