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Abstract

Serotonin is crucial for orbitofrontal cortex function and for the treatment of obsessive-compulsive disorder. Using a neurocomputational model of the role of serotonin in orbitofrontal function, we show that (a) low serotonin leads to perseverative neuronal activity, with the network getting “stuck” in specific states; (b) low serotonin leads to an increased tendency both to develop obsessions—strong attractors to which the network activity tends and which are difficult to escape—and to fall into existing obsessions; (c) excessive glutamatergic activity, which may occur in obsessive-compulsive disorder, also leads to an increased tendency to develop obsessions and fall into existing obsessions; (d) increasing serotonin decreases these pathological tendencies, even if they are caused by excessive glutamatergic activity; and (e) the different effects of 5-HT_1A and 5-HT_2A serotonin receptors on neuronal activity explain the differential effects of drugs that target these receptors.

Keywords

obsessive-compulsive disorder serotonin orbitofrontal cortex perseveration computational model

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The Role of Serotonin in Orbitofrontal Function and Obsessive-Compulsive Disorder

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