Shift Work,Light at Night,and the Risk of Breast Cancer

Abstract

Studies of the effect of shift work have identified several negative health outcomes, most notably breast cancer. Disruption of circadian rhythm by exposure to light at night has been identified as the mechanism likely responsible for this outcome. This article recommends that health care institutions work with occupational health nurses to develop and implement hazard communication and policies concerning shift work, exposure to light at night, and increased risk for negative health outcomes, particularly breast cancer.

References

Aanonsen

(1959). Medical problems of shift-work. Industrial Medicine and Surgery, 28, 422–427.

Akerstedt

Knutsson

Alfredsson

, & Theorell

(1984). Shift work and cardiovascular disease. Scandinavian Journal of Work, Environment & Health, 10(6 Spec. No.), 409–414.

Althuis

M. D.

Dozier

J. M.

Anderson

W. F.

Devesa

S. S.

, & Brinton

L. A.

(2005). Global trends in breast cancer incidence and mortality 1973–1997. International Journal of Epidemiology, 34(2), 405–412.

Armstrong

B. G.

Nolin

A. D.

, & McDonald

A. D.

(1989). Work in pregnancy and birth weight for gestational age. British Journal of Industrial Medicine, 46(3), 196–199.

Aschoff

Hoffmann

Pohl

, & Wever

(1975). Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber. Chronobiologia, 2(1), 23–78.

Axelsson

Rylander

, & Molin

(1989). Outcome of pregnancy in relation to irregular and inconvenient work schedules. British Journal of Industrial Medicine, 46(6), 393–398.

Baehr

E. K.

Eastman

C. I.

Revelle

Olson

S. H.

Wolfe

L. F.

, & Zee

P. C.

(2003). Circadian phase-shifting effects of nocturnal exercise in older compared with young adults. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 284(6), R1542–R1550.

Baehr

E. K.

Revelle

, & Eastman

C. I.

(2000). Individual differences in the phase and amplitude of the human circadian temperature rhythm: With an emphasis on morningness-eveningness. Journal of Sleep Research, 9(2), 117–127.

Barger

L. K.

Wright

K. P.

Jr. Hughes

R. J.

, & Czeisler

C. A.

(2004). Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 286(6), R1077–R1084.

10.

Barton

(1994). Choosing to work at night: A moderating influence on individual tolerance to shift work. Journal of Applied Psychology, 79(3), 449–454.

11.

Barton

, & Folkard

(1993). Advancing versus delaying shift systems. Ergonomics, 36(1–3), 59–64.

12.

Bayer

(1986). Notifying workers at risk: The politics of the right-to-know. American Journal of Public Health, 76(11), 1352–1356.

13.

Blask

D. E.

(2009). Melatonin, sleep disturbance and cancer risk. Sleep Medicine Reviews, 13(4), 257–264.

14.

Blask

D. E.

Brainard

G. C.

Dauchy

R. T.

Hanifin

J. P.

Davidson

L. K.

Krause

J. A.

(2005). Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Research, 65(23), 11174–11184.

15.

Blask

D. E.

Dauchy

R. T.

Sauer

L. A.

Krause

J. A.

, & Brainard

G. C.

(2003). Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: Impact of constant light-induced nocturnal melatonin suppression. Breast Cancer Research and Treatment, 79(3), 313–320.

16.

Boggild

, & Knutsson

(1999). Shift work, risk factors and cardiovascular disease. Scandinavian Journal of Work, Environment & Health, 25(2), 85–99.

17.

Boivin

D. B.

, & James

F. O.

(2002). Circadian adaptation to night-shift work by judicious light and darkness exposure. Journal of Biological Rhythms, 17(6), 556–567.

18.

Bradbury

J. A.

(1989). The policy implications of differing concepts of risk. Science, Technology & Human Values, 14(4), 380–399.

19.

Brainard

G. C.

Lewy

A. J.

Menaker

Fredrickson

R. H.

Miller

L. S.

Weleber

R. G.

(1988). Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers. Brain Research, 454(1–2), 212–218.

20.

Brainard

G. C.

Richardson

B. A.

Petterborg

L. J.

, & Reiter

R. J.

(1982). The effect of different light intensities on pineal melatonin content. Brain Research, 233(1), 75–81.

21.

Brzezinski

(1997). Melatonin in humans. New England Journal of Medicine, 336(3), 186–195.

22.

Budnick

L. D.

Lerman

S. E.

, & Nicolich

M. J.

(1995). An evaluation of scheduled bright light and darkness on rotating shiftworkers: Trial and limitations. American Journal of Industrial Medicine, 27(6), 771–782.

23.

Bullough

J. D.

Rea

M. S.

, & Figueiro

M. G.

(2006). Of mice and women: Light as a circadian stimulus in breast cancer research. Cancer Causes & Control, 17(4), 375–383.

24.

Bureau of Labor Statistics. (2005). Workers on flexible and shift schedules in 2004 summary. Washington, DC: Author.

25.

Burgess

H. J.

Sharkey

K. M.

, & Eastman

C. I.

(2002). Bright light, dark and melatonin can promote circadian adaptation in night shift workers. Sleep Medicine Reviews, 6(5), 407–420.

26.

Cermakian

, & Boivin

D. B.

(2003). A molecular perspective of human circadian rhythm disorders. Brain Research: Brain Research Reviews, 42(3), 204–220.

27.

Cohen

Lippman

, & Chabner

(1978). Role of pineal gland in aetiology and treatment of breast cancer. Lancet, 2(8094), 814–816.

28.

Colligan

M. J.

, & Rosa

R. R.

(1990). Shiftwork effects on social and family life. Occupational Medicine, 5(2), 315–322.

29.

Cos

Fernandez

Guezmes

, & Sanchez-Barcelo

E. J.

(1998). Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Research, 58(19), 4383–4390.

30.

Crowley

S. J.

Lee

Tseng

C. Y.

Fogg

L. F.

, & Eastman

C. I.

(2003). Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. Journal of Biological Rhythms, 18(6), 513–523.

31.

Czeisler

C. A.

Allan

J. S.

Strogatz

S. H.

Ronda

J. M.

Sanchez

Rios

C. D.

(1986). Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science, 233(4764), 667–671.

32.

Czeisler

C. A.

Chiasera

A. J.

, & Duffy

J. F.

(1991). Research on sleep, circadian rhythms and aging: Applications to manned spaceflight. Experimental Gerontology, 26(2–3), 217–232.

33.

Czeisler

C. A.

Johnson

M. P.

Duffy

J. F.

Brown

E. N.

Ronda

J. M.

, & Kronauer

R. E.

(1990). Exposure to bright light and darkness to treat physiologic maladaptation to night work. New England Journal of Medicine, 322(18), 1253–1259.

34.

Czeisler

C. A.

, & Klerman

E. B.

(1999). Circadian and sleep-dependent regulation of hormone release in humans. Recent Progress in Hormone Research, 54, 97–130; discussion 130–132.

35.

Czeisler

C. A.

Moore-Ede

M. C.

, & Coleman

R. H.

(1982). Rotating shift work schedules that disrupt sleep are improved by applying circadian principles. Science, 217(4558), 460–463.

36.

Czeisler

C. A.

Weitzman

Moore-Ede

M. C.

Zimmerman

J. C.

, & Knauer

R. S.

(1980). Human sleep: Its duration and organization depend on its circadian phase. Science, 210(4475), 1264–1267.

37.

Czeisler

C. A.

Zimmerman

J. C.

Ronda

J. M.

Moore-Ede

M. C.

, & Weitzman

E. D.

(1980). Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep, 2(3), 329–346.

38.

Dardente

, & Cermakian

(2007). Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiology International, 24(2), 195–213.

39.

Davis

, & Mirick

D. K.

(2006). Circadian disruption, shift work and the risk of cancer: A summary of the evidence and studies in Seattle. Cancer Causes & Control, 17(4), 539–545.

40.

Davis

Mirick

D. K.

, & Stevens

R. G.

(2001). Night shift work, light at night, and risk of breast cancer. Journal of the National Cancer Institute, 93(20), 1557–1562.

41.

Dawson

Encel

, & Lushington

(1995). Improving adaptation to simulated night shift: Timed exposure to bright light versus daytime melatonin administration. Sleep, 18(1), 11–21.

42.

Duffy

J. E.

Dijk

D. J.

Hall

E. F.

, & Czeisler

C. A.

(1999). Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. Journal of Investigative Medicine, 47(3), 141–150.

43.

Eastman

C. I.

(1992). High-intensity light for circadian adaptation to a 12-h shift of the sleep schedule. American Journal of Physiology, 263(2 Pt 2), R428–R436.

44.

Eastman

C. I.

Liu

, & Fogg

L. F.

(1995). Circadian rhythm adaptation to simulated night shift work: Effect of nocturnal bright-light duration. Sleep, 18(6), 399–407.

45.

Efinger

Nelson

L. C.

, & Starr

J. M.

(1995). Understanding circadian rhythms: A holistic approach to nurses and shift work. Journal of Holistic Nursing, 13(4), 306–322.

46.

Erren

T. C.

Morfeld

Stork

Knauth

von Mulmann

M. J.

Breitstadt

(2009). Shift work, chronodisruption and cancer? The IARC 2007 challenge for research and prevention and 10 theses from the Cologne Colloquium 2008. Scandinavian Journal of Work, Environment & Health, 35(1), 74–79.

47.

Erren

T. C.

Pape

H. G.

Reiter

R. J.

, & Piekarski

(2008). Chronodisruption and cancer. Naturwissenschaften, 95(5), 367–382.

48.

Erren

T. C.

, & Reiter

R. J.

(2009). Defining chronodisruption. Journal of Pineal Research, 46(3), 245–247.

49.

Feychting

, & Ahlbom

(2001). [Can light exposure affect the risk of breast cancer? Female flight attendants and shift-workers probably the most vulnerable groups]. Lakartidningen, 98(40), 4316–4318.

50.

Feychting

Osterlund

, & Ahlbom

(1998). Reduced cancer incidence among the blind. Epidemiology, 9(5), 490–494.

51.

Foret

Touron

Benoit

, & Bouard

(1985). Sleep and body temperature in “morning” and “evening” people. Sleep, 8(4), 311–318.

52.

Gold

D. R.

Rogacz

Bock

Tosteson

T. D.

Baum

T. M.

Speizer

F. E.

(1992). Rotating shift work, sleep, and accidents related to sleepiness in hospital nurses. American Journal of Public Health, 82(7), 1011–1014.

53.

Guerrero

J. M.

, & Reiter

R. J.

(2002). Melatonin-immune system relationships. Current Topics in Medicinal Chemistry, 2(2), 167–179.

54.

Hansen

(2001a). Increased breast cancer risk among women who work predominantly at night. Epidemiology, 12(1), 74–77.

55.

Hansen

(2001b). Light at night, shiftwork, and breast cancer risk. Journal of the National Cancer Institute, 93(20), 1513–1515.

56.

Hansen

(2006). Risk of breast cancer after night- and shift work: Current evidence and ongoing studies in Denmark. Cancer Causes & Control, 17(4), 531–537.

57.

Haus

, & Smolensky

(2006). Biological clocks and shift work: Circadian dysregulation and potential long-term effects. Cancer Causes & Control, 17(4), 489–500.

58.

Hill

S. M.

, & Blask

D. E.

(1988). Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Research, 48(21), 6121–6126.

59.

Holmes

M. M.

Galea

L. A.

Mistlberger

R. E.

, & Kempermann

(2004). Adult hippocampal neurogenesis and voluntary running activity: Circadian and dose-dependent effects. Journal of Neuroscience Research, 76(2), 216–222.

60.

Horne

J. A.

, & Ostberg

(1976). A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. International Journal of Chronobiology, 4(2), 97–110.

61.

Hrushesky

W. J. M.

, & Blask

D. E.

(2004). Re: Melatonin and breast cancer: A prospective study. Journal of the National Cancer Institute, 96(11), 888–889.

62.

International Agency for Research on Cancer. (2009). Complete list of agents evaluated and their classification. Retrieved from http://monographs.iarc.fr/ENG/Classification/index.php

63.

James

F. O.

Cermakian

, & Boivin

D. B.

(2007). Circadian rhythms of melatonin, cortisol, and clock gene expression during simulated night shift work. Sleep, 30(11), 1427–1436.

64.

Jasser

S. A.

Blask

D. E.

, & Brainard

G. C.

(2006). Light during darkness and cancer: Relationships in circadian photoreception and tumor biology. Cancer Causes & Control, 17(4), 515–523.

65.

Keller

S. M.

(2009). Effects of extended work shifts and shift work on patient safety, productivity, and employee health. AAOHN Journal, 57(12), 497–502; quiz 503–494.

66.

Kelsey

J. L.

, & Bernstein

(1996). Epidemiology and prevention of breast cancer. Annual Review of Public Health, 17, 47–67.

67.

Kerenyi

(2002). Re: Night shift work, light at night, and risk of breast cancer. Journal of the National Cancer Institute, 94(7), 531–532.

68.

Kerkhof

G. A.

(1991). Differences between morning-types and evening-types in the dynamics of EEG slow wave activity during night sleep. Electroencephalography and Clinical Neurophysiology, 78(3), 197–202.

69.

Kerkhof

G. A.

, & Lancel

(1991). EEG slow wave activity, REM sleep, and rectal temperature during night and day sleep in morning-type and evening-type subjects. Psychophysiology, 28(6), 678–688.

70.

Klinke

, & Renn

(2002). A new approach to risk evaluation and management: Risk-based, precaution-based, and discourse-based strategies. Risk Analysis, 22(6), 1071–1094.

71.

Knauth

(1993). The design of shift systems. Ergonomics, 36(1–3), 15–28.

72.

Knauth

(1998). Innovative worktime arrangements. Scandinavian Journal of Work, Environment & Health, 24(Suppl. 3), 13–17.

73.

Knutsson

(1995). Increased risk of ischaemic heart disease in shift workers. Occupational Medicine (London), 45(1), 55.

74.

Kolstad

H. A.

(2008). Nightshift work and risk of breast cancer and other cancers: A critical review of the epidemiologic evidence. Scandinavian Journal of Work, Environment & Health, 34(1), 5–22.

75.

Lewy

A. J.

Sack

R. L.

Miller

L. S.

Hoban

T. M.

Singer

C. M.

Samples

J. R.

(1986). The use of plasma melatonin levels and light in the assessment and treatment of chronobiologic sleep and mood disorders. Journal of Neural Transmission Supplementum, 21, 311–322.

76.

Lewy

A. J.

Wehr

T. A.

Goodwin

F. K.

Newsome

D. A.

, & Markey

S. P.

(1980). Light suppresses melatonin secretion in humans. Science, 210(4475), 1267–1269.

77.

Lie

J. A.

Roessink

, & Kjaerheim

(2006). Breast cancer and night work among Norwegian nurses. Cancer Causes & Control, 17(1), 39–44.

78.

Loudoun

R. J.

, & Bohle

P. L.

(1997). Work/non-work conflict and health in shiftwork: Relationships with family status and social support. International Journal of Occupational and Environmental Health, 3(Suppl. 2), S71–S77.

79.

Lynch

H. J.

Deng

M. H.

, & Wurtman

R. J.

(1984). Light intensities required to suppress nocturnal melatonin secretion in albino and pigmented rats. Life Sciences, 35(8), 841–847.

80.

Marelli

M. M.

Limonta

Maggi

Motta

, & Moretti

R. M.

(2000). Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells. Prostate, 45(3), 238–244.

81.

Martin

S. K.

, & Eastman

C. I.

(1998). Medium-intensity light produces circadian rhythm adaptation to simulated night-shift work. Sleep, 21(2), 154–165.

82.

McDonald

A. D.

McDonald

J. C.

Armstrong

Cherry

N. M.

Nolin

A. D.

, & Robert

(1988). Prematurity and work in pregnancy. British Journal of Industrial Medicine, 45(1), 56–62.

83.

McIntyre

I. M.

Norman

T. R.

Burrows

G. D.

, & Armstrong

S. M.

(1989). Human melatonin suppression by light is intensity dependent. Journal of Pineal Research, 6(2), 149–156.

84.

Mecacci

, & Zani

(1983). Morningness-eveningness preferences and sleep-waking diary data of morning and evening types in student and worker samples. Ergonomics, 26(12), 1147–1153.

85.

Megdal

S. P.

Kroenke

C. H.

Laden

Pukkala

, & Schernhammer

E. S.

(2005). Night work and breast cancer risk: A systematic review and meta-analysis. European Journal of Cancer, 41(13), 2023–2032.

86.

Mistlberger

R. E.

(1991). Effects of daily schedules of forced activity on free-running rhythms in the rat. Journal of Biological Rhythms, 6(1), 71–80.

87.

Monk

T. H.

(2000). What can the chronobiologist do to help the shift worker? Journal of Biological Rhythms, 15(2), 86–94.

88.

Mosendane

, & Raal

F. J.

(2008). Shift work and its effects on the cardiovascular system. Cardiovascular Journal of South Africa, 19(4), 210–215.

89.

Newbauer

A. C.

(1992). Psychometric comparison of two circadian rhythm questionnaires and their relationship with personality. Personality and Individual Differences, 13, 125–131.

90.

Newcomb

P. A.

Storer

B. E.

Longnecker

M. P.

Mittendorf

Greenberg

E. R.

Clapp

R. W.

(1994). Lactation and a reduced risk of premenopausal breast cancer. New England Journal of Medicine, 330(2), 81–87.

91.

O'Leary

E. S.

Schoenfeld

E. R.

Stevens

R. G.

Kabat

G. C.

Henderson

Grimson

(2006). Shift work, light at night, and breast cancer on Long Island, New York. American Journal of Epidemiology, 164(4), 358–366.

92.

Orth-Gomer

(1983). Intervention on coronary risk factors by adapting a shift work schedule to biologic rhythmicity. Psychosomatic Medicine, 45(5), 407–415.

93.

Owens

J. A.

(2007). Sleep loss and fatigue in healthcare professionals. Journal of Perinatal & Neonatal Nursing, 21(2), 92–100; quiz 101–102.

94.

Panda

Hogenesch

J. B.

, & Kay

S. A.

(2002). Circadian rhythms from flies to human. Nature, 417(6886), 329–335.

95.

Parent-Thirion

Macías

E. F.

Hurley

, & Vermeylen

(2007). Fourth European Working Conditions Survey. Dublin: European Foundation for the Improvement of Living and Working Conditions.

96.

Parkin

D. M.

(2001). Global cancer statistics in the year 2000. Lancet Oncology, 2(9), 533–543.

97.

Parkin

D. M.

, & Fernandez

L. M.

(2006). Use of statistics to assess the global burden of breast cancer. Breast Journal, 12(Suppl. 1), S70–S80.

98.

Patel

(2006). Shift work, light at night and risk of breast cancer. Occupational Medicine (London), 56(6), 433.

99.

Pauley

S. M.

(2004). Lighting for the human circadian clock: Recent research indicates that lighting has become a public health issue. Medical Hypotheses, 63, 588–596.

100.

Pierce

J. L.

, & Newstrom

J. W.

(1983). The design of flexible work schedules and employee responses: Relationships and process. Journal of Occupational Behavior, 4, 247–262.

101.

Pietroiusti

Forlini

Magrini

Galante

Coppeta

Gemma

(2006). Shift work increases the frequency of duodenal ulcer in H pylori infected workers. Occupational and Environmental Medicine, 63(11), 773–775.

102.

Porock

, & Gentry

(2002). Re: Night shift work, light at night, and risk of breast cancer. Journal of the National Cancer Institute, 94(7), 530–531; author reply 533.

103.

Raffensperger

, & deFur

P. L.

(1999). Implementing the precautionary principle: Rigorous science and solid ethics. Human and Ecological Risk Assessment, 5(5), 933–941.

104.

Rea

M. S.

Bierman

Figueiro

M. G.

, & Bullough

J. D.

(2008). A new approach to understanding the impact of circadian disruption on human health. Journal of Circadian Rhythms, 6, 7.

105.

Refinetti

, & Menaker

(1992). The circadian rhythm of body temperature. Physiology & Behavior, 51(3), 613–637.

106.

Reiter

R. J.

(1985). Action spectra, dose-response relationships, and temporal aspects of light's effects on the pineal gland. Annals of New York Academy of Sciences, 453, 215–230.

107.

Rimler

Lupowitz

, & Zisapel

(2002). Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells. Neuroendocrinology Letters, 23(Suppl. 1), 45–49.

108.

Sack

R. L.

, & Lewy

A. J.

(1997). Melatonin as a chronobiotic: Treatment of circadian desynchrony in night workers and the blind. Journal of Biological Rhythms, 12(6), 595–603.

109.

Samel

Wegmann

H. M.

Vejvoda

Maass

Gundel

, & Schutz

(1991). Influence of melatonin treatment on human circadian rhythmicity before and after a simulated 9-hr time shift. Journal of Biological Rhythms, 6(3), 235–248.

110.

Santhi

Aeschbach

Horowitz

T. S.

, & Czeisler

C. A.

(2008). The impact of sleep timing and bright light exposure on attentional impairment during night work. Journal of Biological Rhythms, 23(4), 341–352.

111.

Santhi

Duffy

J. F.

Horowitz

T. S.

, & Czeisler

C. A.

(2005). Scheduling of sleep/darkness affects the circadian phase of night shift workers. Neuroscience Letters, 384(3), 316–320.

112.

Schernhammer

E. S.

Kroenke

C. H.

Laden

, & Hankinson

S. E.

(2006). Night work and risk of breast cancer. Epidemiology, 17(1), 108–111.

113.

Schernhammer

E. S.

Laden

Speizer

F. E.

Willett

W. C.

Hunter

D. J.

Kawachi

(2001). Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. Journal of the National Cancer Institute, 93(20), 1563–1568.

114.

Schernhammer

E. S.

Laden

Speizer

F. E.

Willett

W. C.

Hunter

D. J.

Kawachi

(2003). Night-shift work and risk of colorectal cancer in the nurses' health study. Journal of the National Cancer Institute, 95(11), 825–828.

115.

Schibler

Ripperger

, & Brown

S. A.

(2003). Peripheral circadian oscillators in mammals: Time and food. Journal of Biological Rhythms, 18(3), 250–260.

116.

Schulte

P. A.

, & Ringen

(1984). Notification of workers at high risk: An emerging public health problem. American Journal of Public Health, 74(5), 485–491.

117.

Sharma

V. K.

, & Chandrashekaran

M. K.

(2005). Zeitgebers (time cues) for biological clocks. Current Science, 89(7), 1136–1146.

118.

Skipper

J. K.

Jr. Jung

F. D.

, & Coffey

L. C.

(1990). Nurses and shiftwork: Effects on physical health and mental depression. Journal of Advanced Nursing, 15(7), 835–842.

119.

Spiegel

, & Sephton

(2002). Re: Night shift work, light at night, and risk of breast cancer. Journal of the National Cancer Institute, 94(7), 530; author reply 532–533.

120.

Stephan

F. K.

(2002). The “other” circadian system: Food as a Zeitgeber. Journal of Biological Rhythms, 17(4), 284–292.

121.

Stern

P. C.

, Fineberg, H. V., & National Research Council (U.S.) Committee on Risk Characterization. (1996). Understanding risk: Informing decisions in a democratic society. Washington, DC: National Academy Press.

122.

Stevens

R. G.

(1987). Electric power use and breast cancer: A hypothesis. American Journal of Epidemiology, 125(4). 556–561.

123.

Stevens

R. G.

(2009). Light-at-night, circadian disruption and breast cancer: Assessment of existing evidence. International Journal of Epidemiology, 38(4), 963–970.

124.

Stevens

R. G.

Blask

D. E.

Brainard

G. C.

Hansen

Lockley

S. W.

Provencio

(2007). Meeting report: The role of environmental lighting and circadian disruption in cancer and other diseases. Environmental Health Perspectives, 115(9), 1357–1362.

125.

Stevens

R. G.

Davis

Thomas

D. B.

Anderson

L. E.

, & Wilson

B. W.

(1992). Electric power, pineal function, and the risk of breast cancer. FASEB Journal, 6(3), 853–860.

126.

Stevens

R. G.

, & Rea

M. S.

(2001). Light in the built environment: Potential role of circadian disruption in endocrine disruption and breast cancer. Cancer Causes & Control, 12(3), 279–287.

127.

Straif

Baan

Grosse

Secretan

El Ghissassi

Bouvard

(2007). Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncology, 8(12), 1065–1066.

128.

Strogatz

S. H.

Kronauer

R. E.

, & Czeisler

C. A.

(1986). Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans. Sleep, 9(2), 353–364.

129.

Swerdlow

(2003). Shift work and breast cancer: A critical review of the epidemiological evidence. Norwich: Health and Safety Executive.

130.

Syme

S. L.

(2005). Historical perspective: The social determinants of disease—some roots of the movement. Epidemiologic Perspectives & Innovations, 2, 2. doi:10.1186/1742-5573-2-2

131.

Tamarkin

Baird

C. J.

, & Almeida

O. F.

(1985). Melatonin: A coordinating signal for mammalian reproduction? Science, 227(4688), 714–720.

132.

Tamarkin

Cohen

Roselle

Reichert

Lippman

, & Chabner

(1981). Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat. Cancer Research, 41(11 Pt 1), 4432–4436.

133.

Tarone

R. E.

(2005). Circadian disruption and breast cancer. Epidemiology, 16(5), 710–711.

134.

Thiis-Evensen

(1958). Shift work and health. Industrial Medicine and Surgery, 27(10), 493–497.

135.

Tickner

(2005). Prevention. In Frumkin

(Ed.), Environmental health: From global to local (pp. 849–894). San Francisco: Jossey-Bass.

136.

Travis

R. C.

Allen

D. S.

Fentiman

I. S.

, & Key

T. J.

(2004). Melatonin and breast cancer: A prospective study. Journal of the National Cancer Institute, 96(6), 475–482.

137.

van Mark

Spallek

Groneberg

D. A.

Kessel

, & Weiler

S. W.

(2010). Correlates shift work with increased risk of gastrointestinal complaints or frequency of gastritis or peptic ulcer in H. pylori-infected shift workers? International Archives of Occupational and Environmental Health, 83(40), 423–433.

138.

Vener

K. J.

Szabo

, & Moore

J. G.

(1989). The effect of shift work on gastrointestinal (GI) function: A review. Chronobiologia, 16(4), 421–439.

139.

Whitson

P. A.

Putcha

Chen

Y. M.

, & Baker

(1995). Melatonin and cortisol assessment of circadian shifts in astronauts before flight. Journal of Pineal Research, 18(3), 141–147.

140.

Wilson

G. D.

(1990). Personality, time of day, and arousal. Personality and Individual Differences, 11, 153–168.

141.

Wise

(2009). Danish night shift workers with breast cancer awarded compensation. British Medical Journal, 338, b1152.

142.

Ying

S. W.

Niles

L. P.

, & Crocker

(1993). Human malignant melanoma cells express high-affinity receptors for melatonin: Antiproliferative effects of melatonin and 6-chloromelatonin. European Journal of Pharmacology, 246(2), 89–96.