Background: School counselors face escalating youth mental health needs and intensified accountability demands while designing and implementing comprehensive school counseling programs and multitiered systems of support (MTSS). Meanwhile, artificial intelligence (AI) is rapidly entering K–12 education, yet existing guidance targets classroom use, leaving school counselors without an ethical, unified framework for integrating AI into their programs. Objectives: This article (a) synthesizes emerging AI theory and school counseling scholarship and (b) proposes a conceptual ASCA–MTSS–AI framework that supports responsible, equity-focused use of AI across the ASCA National Model®’s components and MTSS tiers. It also clarifies implications for counselor education, policy, and future research. Research Questions: Guiding questions included: How can three families of AI tools map onto ASCA components across tiers? How can AI enhance, rather than undermine, equity, privacy, and the relational core of school counseling? Methods: Using a conceptual synthesis approach, the article integrates literature on AI-assisted mental health interventions, predictive analytics, learning analytics dashboards, and human–AI complementarity with comprehensive school counseling programs and MTSS frameworks. A crosswalk table and vignettes illustrate feasible, low-risk implementation pathways. Results: The framework clarifies how specific AI tools can enhance data-informed comprehensive school counseling programs at each tier while maintaining oversight. Examples highlight low-risk pilots, participatory design, and bias audits embedded in program review cycles. Conclusion: With careful governance, professional learning, and equity safeguards, AI can help school counselors reallocate time from administrative tasks to proactive, relationship-centered services across the ASCA–MTSS continuum, ultimately strengthening access, responsiveness, and outcomes for all students.