POEMS syndrome is a rare plasma cell disorder that is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes, most commonly affecting middle-aged men. Due to its rarity and clinical overlap with other conditions, diagnosis relies on established mandatory, major, and minor criteria. We report a case of POEMS syndrome in a 17-year-old female. This case contributes to the limited literature on pediatric and adolescent presentations of POEMS syndrome and underscores clinical features that may aid in earlier recognition and diagnosis.
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