Restricted accessResearch articleFirst published online 2025-08
Reprogramming Stars #23: Charting Cell Fate Crossroads from the Interplay Between Epigenetics,Transcription,and 3D Chromatin Architecture—An Interview with Dr. Effie Apostolou
ApostolouE, FerrariF, WalshRM, et al.Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell, 2013; 12(6):699–712.
2.
BrevesSL, Di GiammartinoDC, NicholsonJ, et al.Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. Mol Cell, 2025; 85(7):1330–1348.e6.
3.
Di GiammartinoDC, KloetgenA, PolyzosA, et al.KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nat Cell Biol, 2019; 21(10):1179–1190.
4.
GargV, YangY, NowotschinS, et al.Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice. Dev Cell, 2025; 60(6):901–917.e12.
5.
LeeU, Laguillo-DiegoA, WongW, et al.Post-mitotic transcriptional activation and 3D regulatory interactions show locus-and differentiation-specific sensitivity to cohesin depletion. bioRxiv, 2025:2025.02.13.638153.
6.
MurphyD, SalatajE, Di GiammartinoDC, et al.3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nat Struct Mol Biol, 2024; 31(1):125–140.
7.
Pelham-WebbB, PolyzosA, WojenskiL, et al.H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization. Mol Cell, 2021; 81(8):1732–1748.e8.
8.
UyeharaCM, ApostolouE. 3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles. Cell Rep, 2023; 42(4):112068.