Myxomas are rare tumors in neonates and tend to have a different presentation compared to adults. We present an infant with a left atrial myxoma presenting with episodic tachycardia who underwent successful surgical excision. In addition, we performed a review of the literature, identifying 17 cases of neonatal myxomas. Unlike adults, neonatal myxomas are more common in males and occur more often on the right side of the heart. Constitutional symptoms such as fever or embolism are rare among neonates. Most patients have favorable outcomes following surgical excision, refuting earlier claims that neonatal myxomas are associated with poor outcomes.
FlenkerH. Connatal endocardial myxoma—case report and pathogenesis. Virchows Arch Abteilung A Pathol Anat. 1972;356(4): 353–358. doi:10.1007/BF00548969
9.
DianzumbaSBCharG. Large calcified right atrial myxoma in a newborn. Rare cause of neonatal death. Br Heart J. 1982;48(2): 177–179. doi:10.1136/hrt.48.2.177
10.
ChanHSSonleyMJMoësCADanemanASmithCRMartinDJ. Primary and secondary tumors of childhood involving the heart, pericardium, and great vessels. A report of 75 cases and review of the literature. Cancer. 1985;56(4): 825–836. doi:10.1002/1097-0142(19850815)56:4<825::aid-cncr2820560421>3.0.co;2-7
11.
BalsaraRKPeliasAJ. Myxoma of right ventricle presenting as pulmonic stenosis in a neonate. Chest. 1983;83(1): 145–146. doi:10.1378/chest.83.1.145
SkillingtonPDBrawnWJEdisBD, et al.Surgical excision of primary cardiac tumours in infancy. Aust N Z J Surg. 1987;57(9): 599–604. doi:10.1111/j.1445-2197.1987.tb01433.x
14.
RussellGADhasmanaJPBerryPJGilbert-BarnessEF. Coexistent cardiac tumours and malformations of the heart. Int J Cardiol. 1989;22(1): 89–98. doi:10.1016/0167-5273(89)90140-x
ButtoFBen ShacharGNajmabadiHSmithG. Massive cardiac tumor presenting as severe cyanosis in a newborn. Pediatr Cardiol. 1994;15(2): 103–104. doi:10.1007/BF00817619
17.
SalleeDSpectorMLvan HeeckerenDWPatelCR. Primary pediatric cardiac tumors: a 17 year experience. Cardiol Young. 1999;9(2): 155–162. doi:10.1017/s1047951100008374
18.
PaladiniDTartaglioneAVassalloMMartinelliP. Prenatal ultrasonographic findings of a cardiac myxoma. Obstet Gynecol. 2003;102(5 Pt 2): 1174–1176. doi:10.1016/s0029-7844(03)00079-6
19.
GeorgeKMPrzygodzkiRMJonasRADi RussoGB. Resection of an obstructive neonatal cardiac myxoma of the infundibulum. Pediatr Cardiol. 2006;27(3): 369–371. doi:10.1007/s00246-005-1216-9
PinedeLDuhautPLoireR. Clinical presentation of left atrial cardiac myxoma: a series of 112 consecutive cases. Medicine (Baltimore). 2001;80(3): 159–172. doi:10.1097/00005792-200105000-00002
26.
WuKHMoXMLiuYL. Clinical analysis and surgical results of cardiac myxoma in pediatric patients. J Surg Oncol. 2009;99(1): 48–50. doi:10.1002/jso.21175
27.
BielefeldKJMollerJH. Cardiac tumors in infants and children: study of 120 operated patients. Pediatr Cardiol. 2013;34(1): 125–128. doi:10.1007/s00246-012-0399-0
28.
BurkeAPVirmaniR. Cardiac myxoma. A clinicopathologic study. Am J Clin Pathol. 1993;100(6): 671–680. doi:10.1093/ajcp/100.6.671
SernichSChauhanASinghDFuchsHCaspiJ. Left atrial myxoma in a child: a challenging diagnosis of a rare lesion. World J Pediatr Congenit Heart Surg. 2013;4(2): 220–222. doi:10.1177/2150135112473124
33.
KumarTKSAliMHirakannawarA, et al.Clinical experience and surgical considerations in the management of cardiac myxomas. Indian J Thorac Cardiovasc Surg. 2004;20(2): 77–82. doi:10.1007/s12055-004-0046-3
34.
SheenADe OliveiraEKimRParhamDLakshmananA. Atrial thrombus in a neonate: a diagnostic challenge. Am J Perinatol Rep. 2015;05(01): e018–e021. doi:10.1055/s-0034-1396567
35.
BeroukhimRSPrakashAValsangiacomo BuechelER, et al.Characterization of cardiac tumors in children by cardiovascular magnetic resonance imaging: a multicenter experience. J Am Coll Cardiol. 2011;58(10): 1044–1054. doi:10.1016/j.jacc.2011.05.027
36.
GevaTGhelaniSJPowellAJ. Magnetic Resonance Imaging. In: ShaddyREPennyDJFeltesTFCettaFMitalS, eds. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult. 10th ed.Lippincott Williams & Wilkins; 2022. 361–397.
