This editorial accompanies an original research article by Dr Elzein and colleagues describing findings of a randomized, placebo-controlled trial of nitric oxide administration during cardiopulmonary bypass surgery in infants undergoing the Norwood procedure.
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References
1.
ElzeinCUrbasCHughesBLiYLefaiverCIlbawiMVricellaL. Efficacy of nitric oxide administration in attenuating ischemia/reperfusion injury during neonatal cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2020;11(4):417–423.
2.
PaparellaDYauTMYoungE. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 2002;21(2):232–244.
3.
BennettMThuysCAugustinS, et al.The safe addition of nitric oxide into the sweep gas of the extracorporeal circuit during cardiopulmonary bypass and extracorporeal life support. J Extra Corpor Technol. 2018;50(4):260–264.
ShaefiSMittelAKlickJ, et al.Vasoplegia after cardiovascular procedures-pathophysiology and targeted therapy. J Cardiothorac Vasc Anesth. 2018;32(2):1013–1022.
6.
EngelmanDTWatanabeMEngelmanRM, et al.Constitutive nitric oxide release is impaired after ischemia and reperfusion. J Thorac Cardiovasc Surg. 1995;110(4 pt 1):1047–1053.
7.
SpinaSLeiCPinciroliRBerraL. Hemolysis and kidney injury in cardiac surgery: the protective role of nitric oxide therapy. Semin Nephrol. 2019;39(5):484–495.
8.
SardoSOsawaEAFincoG, et al.Nitric oxide in cardiac surgery: a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth. 2018;32(6):2512–2519.
9.
LeiCBerraLRezoagliE, et al.Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery. Am J Respir Crit Care Med. 2018;198(10):1279–1287.
LangJDJrSmithABBrandonA, et al.A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation. PLoS One. 2014;9(2):e86053.
12.
BolliR. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J Mol Cell Cardiol. 2001;33(11):1897–1918.
13.
ChecchiaPABronickiRAMuenzerJT, et al.Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children—a randomized trial. J Thorac Cardiovasc Surg. 2013;146(3):530–536.
14.
JamesCMillarJHortonSBrizardCMolesworthCButtW. Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial. Intensive Care Med. 2016;42(11):1744–1752.
15.
GianettiJDel SartoPBevilacquaS, et al.Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J Thorac Cardiovasc Surg. 2004;127(1):44–50.
16.
SchlapbachLJHortonSBLongDA, et al.Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open. 2019;9(8):e026664.
17.
GrahamEM. The utility of steroids in pediatric cardiac operations. Pediatr Crit Care Med. 2014;15(5):492–493.
18.
GrahamEMAtzAMMcHughKE, et al.Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: results from a randomized trial. J Thorac Cardiovasc Surg. 2014;147(3):902–908.
19.
HillKDBaldwinHSBichelDP, et al.Rationale and design of the STeroids to REduce systemic inflammation after infant heart Surgery (STRESS) trial. Am Heart J. 2019;220:192–202.
20.
FelkerGMMaiselAS. A global rank end point for clinical trials in acute heart failure. Circ Heart Fail. 2010;3(5):643–646.