Renal vein thrombosis (RVT) is the most common noncatheter-related thrombosis encountered in infancy, most of which occurs in neonates. The optimal management strategy for neonatal RVT is unclear. Fibrinolytic and heparin therapy may play a role in preventing chronic renal failure in neonates with bilateral RVT. However, the use of fibrinolytics early after any major surgery requires tremendous caution. In this report, we describe the successful use of fibrinolysis in a neonate with bilateral RVT after repair of truncus arteriosus in the early postoperative period.
SchmidtBAndrewM. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics. 1995;96(5 pt 1):939–943.
2.
LauKKStoffmanJMWilliamsS. Neonatal renal vein thrombosis: Review of the English language literature between 1992 and 2006. Pediatrics. 2007;120:e1278–e1284.
3.
ZigmanAYazbeckSEmilSNguyenL. Renal vein thrombosis: A 10 year review. J Pediatr Surg. 2000;35(11):1540–1542.
4.
MessingerYSheafferJWMrozekJSmithCMSinaikoAR. Renal outcome of neonatal renal venous thrombosis: Review of 28 patients and effectiveness of fibrinolytics and heparin in 10 patients. Pediatrics. 2006;118:e1478–e1484
5.
MassicotteMPDixDMonaglePAdamsMAndrewM. Central venous catheter related thrombosis in children: Analysis of the Canadian registry of venous thromboembolic complications. J Pediatr. 1998;133(6):770–776.
6.
VeldmanANoldMFBehnkeIM. Thrombosis in critically ill neonate: incidence, diagnosis and management. Vasc Health Risk Manag. 2008;4(6):1337–1348.
7.
KhanJUTakemotoCMCasellaJFStreiffMBNwankwoIJKimHS. Catheter directed thrombolysis of inferior vena cava thrombosis in a 13 day old neonate and review of literature. Cardiovasc Intervent Radiol. 2008;31(suppl 2):S153–S160.
8.
DillonPWFoxPSBergCJCardellaJFKrummelTM. Recombinant tissue plasminogen activator for neonatal and pediatric vascular thrombolytic therapy. J Pediatr Surg. 1993;28(10):1264–1269.
