Objective. To assess the theoretical and practical knowledge of health care providers (HCPs) in relation to the use of metered-dose inhalers (MDIs) and spacer devices. Methods. A cross-sectional study was conducted in Riyadh, Saudi Arabia, among 52 HCPs using a stratified random sampling technique. A questionnaire was used to assess theoretical knowledge; practical knowledge was assessed by direct demonstration of the use of an MDI and a spacer device. Results. Among the participants, 57% were female. The majority provided education to their patients (92%). Of the HCPs, 36.5% completed the demonstration of holding the spacer with a mask and MDI together and then shaking well 4 to 5 times, 78.8% completed the demonstration of cap removal, 15.4% completed the demonstration of checking for any foreign body in the spacer, 78.8% completed the demonstration of holding the device properly, 69.2% completed the demonstration of inhaling slowly and deeply, 55.8% completed the demonstration of maintaining the seal for 5 to 6 breaths after the MDI is pressed, 26.9% completed the demonstration of “if more puffs of medication are prescribed, complete these puffs,” and 25% completed the demonstration of washing the spacer with warm soapy water. The overall scores were good (16.6%), fair (44.4%), and poor (39%). Conclusion. Most of the HCPs in this study lacked basic knowledge and skills regarding the proper way to instruct their patients to use MDIs and spacer devices. There is a need to establish continuing education programs for HCPs about asthma inhaler knowledge and technique.