In search for the Holy Grail: Suggestions for studies to define delta changes to diagnose or exclude acute myocardial infarction: a position paper from the study group on biomarkers of the Acute Cardiovascular Care Association

Abstract

Get full access to this article

View all access options for this article.

References

Thygesen

Alpert

Jaffe

. Third universal definition of myocardial infarction. Eur Heart J 2012; 33: 2551–2567.

Apple

Collinson

PO.

IFCC task force on clinical applications of cardiac biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2012; 58: 54–61.

White

HD.

Higher sensitivity troponin levels in the community: what do they mean and how will the diagnosis of myocardial infarction be made?

Am Hrt J 2010, 159: 933–936.

Reichlin

Irfan

Twerenbold

. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circ 2011; 124: 136–145.

Giannitsis

Becker

Kurz

. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 2010; 56: 642–650.

Apple

Smith

Pearce

. Delta changes for optimizing clinical specificity and 60-day risk of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome utilizing the ADVIA Centaur TnI-Ultra assay. Clin Biochem 2012; 45: 711–713.

Keller

Zeller

Ojeda

. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011; 306: 2684–2693.

Jaffe

Babuin

Apple

FS.

Biomarkers in acute cardiac disease – The present and the future. J Am Coll Cardiol 2006; 48: 1–11.

Hammarsten

Sigurjonsdottir

. Troponin T percentiles from a random population sample, emergency room patients and patients with myocardial infarction. Clin Chem 2012; 58: 628–637.

10.

Bjurman

Larsson

Johanson

. Small changes in troponin T levels are common in patients with non-ST-segment elevation myocardial infarction and are linked to higher mortality. JACC 2013; 62: 1231–1238.

11.

Braunwald

Morrow

DA.

Unstable angina: is it time for a requiem?

Circ 2013; 127: 2452–2457.

12.

Santalȯ

Martin

Velilla

. Using high-sensitivity Troponin T: the importance of the proper Gold Standard. Am J Med 2013; 126: 709–717.

13.

Saaby

Poulsen

Hosbond

. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction. Am J Med 2013; 126: 789–797.

14.

Hamm

Bassand

Agewall

., and the ESC Committee for Practice Guidelines. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999–3054.

15.

Korosoglou

Lehrke

Mueller

. Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque. Heart 2011; 97: 785–786.