Since Herrick’s description of the clinical picture of acute myocardial infarction exactly one century ago (1912), there have been three phases of therapy: Phase 1 (1912–1961, bed rest and ‘expectant’ treatment); Phase 2 (1961–1974, the coronary care unit); and Phase 3 (1975–present, myocardial reperfusion). We are now on the cusp of Phase 4, which comprises efforts to reduce myocardial perfusion injury as well as regenerative medicine.
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