AbifadelMVarretMRabesJP, et al.
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet2003;
34: 154–156.
2.
VeljicIPolovinaMMilinkovicI, et al.
Lipoprotein apheresis and proprotein convertase subtilisin/kexin type 9 inhibitors: do we have a vanquishing new strategy?Eur J Prev Cardiol2019;
26: 739–742.
3.
ZentiMGAltomariALupoMG, et al.
From lipoprotein apheresis to proprotein convertase subtilisin/kexin type 9 inhibitors: impact on low-density lipoprotein cholesterol and C-reactive protein levels in cardiovascular disease patients. Eur J Prev Cardiol2018;
25: 1843–1851.
4.
ZhangDWLagaceTAGarutiR, et al.
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem2007;
282: 18602–18612.
5.
FitzgeraldKFrank-KamenetskyMShulga-MorskayaS, et al.
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet2014;
38360–68.
6.
RobinsonJGNedergaardBSRogersWJ, et al.
Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA2014;
311: 1870–1882.
7.
SabatineMSGiuglianoRPWiviottSD, et al.; for the Open-label study of long-term evaluation against LDLCI.
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med2015;
372: 1500–1509.
8.
SabatineMSGiuglianoRPKeechAC, et al.; for the FOURIER Steering Committee and Investigators. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med2017;
376: 1713–1722.
9.
SchwartzGGStegPGSzarekM, et al.; for the ODYSSEY OUTCOMES Committees and Investigators.
Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med2018;
379: 2097–2107.
10.
GiuglianoRPKeechAMurphySA, et al.
Clinical efficacy and safety of evolocumab in high-risk patients receiving a statin: secondary analysis of patients with low LDL cholesterol levels and in those already receiving a maximal-potency statin in a randomized clinical trial. JAMA Cardiol2017;
2: 1385–1391.
11.
GiuglianoRPPedersenTRParkJG, et al.; FOURIER Investigators.
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial. Lancet2017;
390: 1962–1971.
12.
SeverPGouni-BertholdIKeechA, et al.
LDL-cholesterol lowering with evolocumab, and outcomes according to age and sex in patients in the FOURIER Trial. Eur J Prev Cardiol, Epub ahead of print 4 February 2020. DOI: 10.1177/2047487320902750.
13.
MachFBaigentCCatapanoAL, et al.; ESC Scientific Document Group.
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J2020;
41: 111–188.