LombardoTARoseLTaeschlerM, et al.The effect of exercise on coronary blood flow, myocardial oxygen consumption and cardiac efficiency in man. Circulation1953; 7: 71–78.
2.
ZuckerIHMuschTI. Benefits of exercise training on cardiovascular dysfunction: molecular and integrative. Am J Physiol Heart Circ Physiol2018; 315: H1027–H1031.
3.
NitertMDDayehTVolkovP, et al.Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes2012; 61: 3322–3332.
4.
BarresRYanJEganB, et al.Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab2012; 15: 405–411.
5.
WieberdinkRGIkramMKKoudstaalPJ, et al.Retinal vascular calibers and the risk of intracerebral hemorrhage and cerebral infarction: the Rotterdam Study. Stroke2010; 41: 2757–2761.
6.
WangJJLiewGKleinR, et al.Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations. Eur Heart J2007; 28: 1984–1992.
7.
NageleMPBarthelmesJLudoviciV, et al.Retinal microvascular dysfunction in heart failure. Eur Heart J2018; 39: 47–56.
8.
HanssenHNickelTDrexelV, et al.Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity. Atherosclerosis2011; 216: 433–439.
9.
StreeseLKADeiserothAHussainS, et al.Physical activity drives healthy microvascular ageing via downregulation of p66ShcEur J Prev Cardiol. 2020; 27: 168–176.
10.
Streese L, Khan AW, Deiseroth A, et al. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE). Eur Heart J 20. Epub ahead of print 20 July 2019. DOI: 10.1093/eurheartj/ehz196.
11.
LaufsUWernerNLinkA, et al.Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation2004; 109: 220–226.
12.
Van CraenenbroeckEMHoymansVYBeckersPJ, et al.Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure. Basic Res Cardiol2010; 105: 665–676.
13.
MiaoQWangQDongL, et al.The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation. Heart Vessels2015; 30: 451–457.
14.
PagninEFadiniGde ToniR, et al.Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress. J Clin Endocrinol Metab2005; 90: 1130–1136.
15.
FadiniGPAlbieroMBonoraBM, et al.p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications. Cardiovasc Diabetol2018; 17: 16–16.
16.
KumarS. P66Shc and vascular endothelial function. Biosci Rep2019; 39: BSR20182134–BSR20182134.
17.
PaneniFCostantinoSVolpeM, et al.Epigenetic signatures and vascular risk in type 2 diabetes: a clinical perspective. Atherosclerosis2013; 230: 191–197.