The ultimate diagnosis of unexplained dyspnoea on exertion: Stay tuned on invasive cardiopulmonary exercise testing and beyond

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References

Parshall

Schwartzstein

Adams

. American Thoracic Society Committee on Dyspnea. An official American Thoracic Society statement: Update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 2012; 185: 435–452.

Abidov

Rozanski

Hachamovitch

. Prognostic significance of dyspnea in patients referred for cardiac stress testing. N Engl J Med 2005; 353: 1889–1898.

Santos

Kitzman

Matsushita

. Prognostic importance of dyspnea for cardiovascular outcomes and mortality in persons without prevalent cardiopulmonary disease: The atherosclerosis risk in communities study. PloS One 2016; 11: e0165111–e0165111.

Biering-Sorensen

Santos

Rivero

. Left ventricular deformation at rest predicts exercise-induced elevation in pulmonary artery wedge pressure in patients with unexplained dyspnoea. Eur J Heart Fail 2017; 19: 101–110.

Bernhardt

Babb

. Exertional dyspnoea in obesity. Eur Respir Rev 2016; 25: 487–495.

DePaso

Winterbauer

Lusk

. Chronic dyspnea unexplained by history, physical examination, chest roentgenogram, and spirometry. Analysis of a seven-year experience. Chest 1991; 100: 1293–1299.

Guazzi

Borlaug

. Pulmonary hypertension due to left heart disease. Circulation 2012; 126: 975–990.

Tolle

Waxman

Van Horn

. Exercise-induced pulmonary arterial hypertension. Circulation 2008; 118: 2183–2189.

Guazzi

Arena

Halle

. 2016 Focused update: Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation 2016; 133: e694–e711.

10.

Oliveira

Waxman

Agarwal

. Pulmonary haemodynamics during recovery from maximum incremental cycling exercise. Eur Respir J 2016; 48: 158–167.

11.

Oldham

Lewis

Opotowsky

. Unexplained exertional dyspnea caused by low ventricular filling pressures: Results from clinical invasive cardiopulmonary exercise testing. Pulm Circ 2016; 6: 55–62.

12.

Obokata

Reddy

Pislaru

. Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation 2017. DOI: 10.1161/CIRCULATIONAHA.116.026807.

13.

Huang

WRS

Oliveira

RKF

Cockrill

. Invasive cardiopulmonary exercise testing in the evaluation of unexplained dyspnea: Insights from a multidisciplinary dyspnea center. Eur J Prev Cardiol 2017. DOI: 10.1177/2047487317709605.

14.

Wolsk

Bakkestrom

Thomsen

. The influence of age on hemodynamic parameters during rest and exercise in healthy individuals. JACC Heart Fail 2017; 5: 337–346.

15.

Galie

Humbert

Vachiery

. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society Of Cardiology (esc) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 2016; 37: 67–119.

16.

Guazzi

. Stress echocardiography combined with cardiopulmonary exercise testing: Opening a new window into diagnosis of heart failure with preserved ejection fraction. Eur J Prev Cardiol 2016; 23: 67–70.

17.

Shimiaie

Sherez

Aviram

. Determinants of effort intolerance in patients with heart failure: Combined echocardiography and cardiopulmonary stress protocol. JACC Heart Fail 2015; 3: 803–814.

18.

Bandera

Generati

Pellegrino

. Mitral regurgitation in heart failure: Insights from CPET combined with exercise echocardiography. Eur Heart J Cardiovasc Imaging 2017; 18: 296–303.