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Abstract

Background

Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B₄ (LTB₄) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB₄ ratio with subclinical atherosclerosis.

Methods

Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants. The lipid mediators RvD1 and LTB₄ were measured by enzyme-linked immunosorbent assay.

Results

Participants with a salivary RvD1/LTB₄ ratio >1 had a significantly lower intima media thickness than those in whom LTB₄ prevailed. The salivary RvD1/LTB4 ratio independently predicted carotid intima media thickness.

Conclusions

The ratio between the proresolving and proinflammatory salivary lipid mediators RvD1 and LTB₄ may serve as a biomarker of non-resolving inflammation and its relation to intima media thickness in cardiovascular disease.

Keywords

Atherosclerosis eicosanoids lipid mediators resolution of inflammation

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