The influence of lunar phases on the occurrence of myocardial infarction: fact or myth? The MONICA/KORA Myocardial Infarction Registry

Abstract

Aims: The potential influence of lunar phases on the occurrence of myocardial infarction is still controversial. The purpose of the present study was to investigate the association of the lunar cycle on the occurrence of fatal and non-fatal myocardial infarction based on a myocardial infarction registry.

Methods and results: We studied 15,985 patients consecutively hospitalised with an acute myocardial infarction (AMI) between 1 January 1985 and 31 December 2007 with a known date of symptom onset who were recruited from a population-based myocardial infarction registry. The exact hour of AMI onset was known for 9813 events. Poisson regression analysis was performed to examine the relation between the lunar cycle and the occurrence of AMI.

There was no association between new moon, full moon, waning moon and waxing moon and the occurrence of AMI. However, we observed that the three days after a new moon may be significantly protective for the occurrence of AMI, rate ratio (RR) 0.94 (95% CI 0.91–0.98), and the day before a new moon had a slightly negative effect (RR 1.06, 95% CI 1.00–1.12). Stratified analysis did not reveal any susceptible subgroups.

Conclusion: The moon phases did not show any apparent association with AMI occurrence. However, there might be a ‘cardioprotective’ time three days after a new moon.

Keywords

Circadian rhythm myocardial infarction epidemiology registries

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References

Vance

. Belief in lunar effects on human behaviour. Psycho Rep 1995; 76: 32–34.

Zimecki

. The lunar cycle: effects on human and animal behavior and physiology. Postepy Hig Med Dosw (Online) 2006; 60: 1–7. Review).

Detry

Vincent

. Circadian rhythms in cardiovascular disease: the crucial hours. J Hum Hypertens 1992; 6(Suppl 1): S3–S8.

Thayer

Verkuil

Brosschot

. Effects of the physical work environment on physiological measures of stress. Eur J Cardiovasc Prev Rehabil 2010; 17: 431–439.

Penteriani

Delgado Mdel

Campioni

. Moonlight makes owls more chatty. PLoS One 2010 Jan 20; 5: e8696–e8696.

Wells

Gionfriddo

Hackett

. Canine and feline emergency room visits and the lunar cycle: 11,940 cases (1992–2002). J Am Vet Med Assoc 2007; 231: 251–253.

Staboulidou

Soergel

Vaske

. The influence of lunar cycle on frequency of birth, birth complications, neonatal outcome and the gender: a retrospective analysis. Acta Obstet Gynecol Scand 2008; 87: 875–879.

Ghiandoni

Seclì

Rocchi

. Does lunar position influence the time of delivery? A statistical analysis. Obstet Gynecol Reprod Biol 1998; 77: 47–50.

Jones

. Lunar association with suicide. Suicide Life Threat Behav 1977; 7: 31–39.

10.

Biermann

Estel

Sperling

. Influence of lunar phases on suicide: the end of a myth? A population-based study. Chronobiol Int 2005; 22: 1137–1143.

11.

Polychronopoulos

Argyriou

Sirrou

. Lunar phases and seizure occurrence: just an ancient legend? Neurology 2006; 66: 1442–1443.

12.

Baxendale

Fisher

. Moonstruck? The effect of the lunar cycle on seizures. Epilepsy Behav 2008; 13: 549–550.

13.

Eisenburger

Schreiber

Vergeiner

. Lunar phases are not related to the occurrence of acute myocardial infarction and sudden cardiac death. Resuscitation 2003; 56: 187–189.

14.

Sha

Song

. Lunar phases, myocardial infarction and hemorrheological character. A Western medical study combined with appraisal of the related traditional Chinese medical theory. Chin Med J (Engl) 1989; 102: 722–725.

15.

Willich

Löwel

Lewis

. Association of wake time and the onset of myocardial infarction. Triggers and mechanisms of myocardial infarction (TRIMM) pilot study. TRIMM Study Group. Circulation 1991; 84(Suppl): VI62–VI67.

16.

Oomman

Ramachandran

Shanmugapriya . A novel trigger for acute coronary syndromes: the effect of lunar cycles on the incidence and in-hospital prognosis of acute coronary syndromes–a 3-year retrospective study. J Indian Med Assoc 2003; 101: 227–228.

17.

Wake

Fukuda

Yoshiyama

. The effect of the gravitation of the moon on acute myocardial infarction. Am J Emerg Med 2007; 25: 256–258.

18.

Meisinger

Hörmann

Heier

. Admission blood glucose and adverse outcomes in non-diabetic patients with myocardial infarction in the reperfusion era. Int J Cardiol 2006; 113: 229–235.

19.

Löwel

Lewis

Hörmann

. Case finding, data quality aspects and comparability of myocardial infarction registers: results of a south German register study. J Clin Epidemiol 1991; 44: 249–260.

20.

Kuch

Heier

von Scheidt

. 20-year-trends in clinical characteristics, therapy and short-term prognosis in acute myocardial infarction according to presenting electrocardiogram – results of the MONICA/KORA Augsburg Myocardial Infarction Registry (1985–2004). Am J Cardiol 2007; 100: 1056–1060.

21.

Alpert

Thygesen

Antman

. Myocardial infarction redefined–a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000; 36: 959–969.

22.

http://www.maa.mhn.de/StarDate/moonphases.html. Moonphases Calendar. Moonphases for the years 1700 till 2199.

23.

Lewis SH. Selbstmeisterung, Schicksal und Lebensrhythmen. 5th ed. Baden-Baden: AMORC, 1982.

24.

Röösli

Jüni

Braun-Fahrländer

. Sleepless night, the moon is bright: longitudinal study of lunar phase and sleep. J Sleep Res 2006; 15: 149–153.

25.

Celec

Ostatnikova

Putz

. The circalunar cycle of salivary testosterone and the visual-spatial performance. Bratisl Lek Listy 2002; 103: 59–69.

26.

Nielsen

. Circadian and circatrigintan changes in osteoblastic activity assessed by serum osteocalcin. Physiological and methodological aspects. Dan Med Bull 1994; 41: 216–227. Review).

27.

Muller

Stone

Turi

. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313: 1315–1322.

28.

Spencer

Goldberg

Becker

. Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction. J Am Coll Cardiol 1998; 31: 1226–1233.

29.

Trappolini

Matteoli

Borgia

. Circadian variations in the onset of acute myocardial infarction. Minerva Cardioangiol 2001; 49: 289–296.

30.

Hansen

Johansson

Gullberg

. Circadian distribution of onset of acute myocardial infarction in subgroups from analysis of 10,791 patients treated in a single center. Am J Cardiol 1992; 69: 1003–1008.

31.

Lewin

. Circadian, day-of-week, and age patterns of the occurrence of acute coronary syndrome in Beijing's emergency medical services system. Am J Emerg Med 2010; 28: 663–667.

32.

ISIS-2-Collaborative Group Morning peak in the incidence of myocardial infarction: experience in the ISIS-2 trial. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Eur Heart J 1992; 13: 594–598. Review).

33.

Willich

Löwel

Lewis

. Weekly variation of acute myocardial infarction. Increased Monday risk in the working population. Circulation 1994; 90: 87–93.

34.

Barnett

Dobson

McElduff

. WHO MONICA Project. Cold periods and coronary events: an analysis of populations worldwide. J Epidemiol Community Health 2005; 59: 551–557.

35.

Kriszbacher

Boncz

Koppán

. Seasonal variations in the occurrence of acute myocardial infarction in Hungary between 2000 and 2004. Int J Cardiol 2008; 129: 251–254.

36.

Loughnan

Nicholls

Tapper

. Demographic, seasonal, and spatial differences in acute myocardial infarction admissions to hospital in Melbourne Australia. Int J Health Geogr 2008; 7: 42–42.

37.

Wolf

Schneider

Breitner

. Air temperature and the occurrence of myocardial infarction in Augsburg, Germany. Circulation 2009; 120: 735–742.

38.

Hopstock

Wilsgaard

Njølstad

. Seasonal variation in incidence of acute myocardial infarction in a sub-Arctic population: the Tromsø Study 1974-2004. Eur J Cardiovasc Prev Rehabil 2011; 18: 320–325.