Carboxymethylated tamarind kernel powder (CMTKP) was synthesized by reacting TKP (tamarind kernel polysaccharide) with monochloroacetic acid in the presence of sodium hydroxide. Semi-interpenetrating polymer networks (SIPN) based on poly-2-hydroxyethyl acrylate (PHEA) were synthesized with variable proportions of TKP and CMTKP, which were named as XTHEA21, XTHEA55, and CMTKP21, CMTKP55, respectively. CMTKP IPNs, being more ionic and hydrophilic, showed more swelling compared to the XTHEA types though the crosslink densities of the former were more in neutral medium and were loaded with less amount of drug (%). Glass transition points of the IPNs was controlled by the crosslinked density of it but not by the blend ratio as Tg of CMTKP55<Tg of CMTKP21. FTIR study confirmed the in-situ polymerization of HEA monomer and subsequent crosslinking in the presence of CMTKP, without any cross-reaction between the two polymers. Higher crosslink density of CMTKP IPNs compared to XTHEA samples caused smaller domains of dispersed phase, as exhibited in FESEM pictures, than that of the latter. CMTKP IPNs released the drug following “Super Case II transport phenomenon” (non-Fickian), which is the same as observed by the others, though XPHEA followed “Fickian Transport”.
JanaSSahaANayakAK, et al.Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles. Colloids Surf B Biointerfaces2013; 105: 303–309.
2.
KaurHAhujaMKumarS, et al.Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery. Int J Biol Macromol2012; 50: 833–839.
3.
SanyasiSKumarAGoswamiC, et al.A carboxy methyl tamarind polysaccharide matrix for adhesion and growth of osteoclast-precursor cells. Carbohydr Polym2014; 101: 1033–1042.
4.
MaliKKDhawaleSCDiasRJ, et al.Delivery of drugs using tamarind gum and modified tamarind gum: a review. Bull Fac Pharm Cairo Univ2019; 57: 1–24.
5.
Iurciuc-TincuCAtanaseLIOchiuzL, et al.Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization. Int J Biol Macromol2020; 147: 629–642.
6.
GhosalKAdakSAgatemorC, et al.Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug. J Polym Res2020; 27: 98.
7.
NayakAKPalDSantraK. Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl. Carbohydr Polym2014; 101: 220–230.
8.
NayakAKHasnainMSAminabhaviTM. Drug delivery using interpenetrating polymeric networks of natural polymers: a recent update. J Drug Deliv Sci Technol2021; 66: 102915.
9.
BoppanaRKulkarniRVMutalikSS, et al.Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug. J Microencapsul2010; 27: 337–344.
10.
ZhangJXuSZhangS, et al. Preparation and characterization of tamarind gum/sodium alginate composite gel beads. Iranian Polym J. 2008; 17: 12.
11.
ChoudharyBPaulSRNayakSK, et al.Understanding the effect of functionalized carbon nanotubes on the properties of tamarind gum hydrogels. Polym Bull2018; 75: 4929–4945.
12.
YadavINayakSKRathnamVS, et al.Reinforcing effect of graphene oxide reinforcement on the properties of poly (vinyl alcohol) and carboxymethyl tamarind gum based phase-separated film. J Mech Behav Mater2018; 81: 61–71.
13.
BeraHBoddupalliSNandikondaS, et al.Alginate gel-coated oil-entrapped alginate–tamarind gum–magnesium stearate buoyant beads of risperidone. Int J Biol Macromol2015; 78: 102–111.
14.
MalviyaRRajSFuloriaS, et al.Evaluation of antitumor efficacy of chitosan-tamarind gum polysaccharide polyelectrolyte complex stabilized nanoparticles of simvastatin. Int Jnanomedicine2021; 16: 2533–2553.
15.
KrishnatKDhawaleSCRemethJD, et al.Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac. Marmara Pharm J2017; 21: 771–782.
16.
NagarajaKKrishna RaoKSZoS, et al.Synthesis of novel tamarind gum-co-poly (acrylamidoglycolic acid)-based pH responsive semi-IPN hydrogels and their Ag nanocomposites for controlled release of chemotherapeutics and inactivation of multi-drug-resistant bacteria. Gels2021; 7: 237.
17.
JhaSMalviyaRFuloriaS, et al.Characterization of microwave-controlled polyacrylamide graft copolymer of tamarind seed polysaccharide. Polymers2022; 14: 1037.
18.
YadavIRathnamVSYogalakshmiY, et al.Synthesis and characterization of polyvinyl alcohol-carboxymethyl tamarind gum based composite films. Carbohydr Polym2017; 165: 159–168.
19.
NayakAKPalD. Tamarind seed polysaccharide: an emerging excipient for pharmaceutical use. Indian J Pharm Educ Res2017; 51: S136–S146.
20.
CaiHTepermeisterMYuanC, et al.Regulating hydrogel mechanical properties with an electric field. Mater Horiz2025; 12: 5388–5399.
21.
HoareTRKohaneDS. Hydrogels in drug delivery: progress and challenges. Polymer2008; 49: 1993–2007.
22.
HongrattanavichitISomsestaNAht-OngD. Biodegradable nanocellulose hydrogels from agricultural waste: impact of defibrillation on mechanical and antimicrobial properties. Polym Renew Resour2024; 16(1): 3–22.
23.
ConeoNRamosYA´vilaGD, et al.Active chitosan-poly (vinyl alcohol) film reinforced with zinc oxide nanoparticles for food packaging applications. Polym Renew Resour2023; 14: 173–194.
24.
ChawananorasestKSaengtongdeePKaemchantuekP. Extraction and characterization of tamarind (tamarind indica L.) seed polysaccharides (TSP) from three difference sources. Molecules2016; 21: 775.
25.
KalogerasIMBrostowW. Glass transition temperatures in binary polymer blends. J Polym Sci B Polym Phys2009; 47: 80–95.
26.
GoyalPKumarVSharmaP. Carboxymethylation of tamarind kernel powder. Carbohydr Polym2007; 69: 251–255.
27.
PradasMMRibellesJLGArocaAS, et al.Interaction between water and polymer chains in poly (hydroxyethyl acrylate) hydrogels. Colloid Polym Sci2001; 279: 323–330.
28.
OmidianHHasherniS-AAskariF, et al. Swelling and crosslink density measurements for hydrogels. Iran J Polym Sci Technol. 1994; 3: 115.
29.
GoswamiSKiranKPandaAB, et al.Synthesis of magnetically active interpenetrating polymer network for drug release. Int J Nanodimension2011; 2(1): 37–48.
30.
GoswamiSChakrabartyD. Synthesis and characterization of sequential interpenetrating polymer networks of novolac resin and poly (Ethyl acrylate). J Appl Polym Sci2006; 99: 2857–2867.
31.
KiranKGoswamiSSharmaPP, et al.Study of drug transport phenomenon of acrylic IPNs embedded with iron oxide nanoparticles. Int J Polym Mater2013; 62(9): 509–516.
32.
KiranKGoswamiS. PMMA/PHEA interpenetrating network embedded with iron oxide nanoparticles for drug delivery applications. Int J Polym Mat Polym Bio2014; 63: 963–970.
33.
KorsmeyerRWGurnyRDoelkerE, et al.Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm1983; 15: 25–35.
34.
RitgerPLPeppasNA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Contr Release1987; 5: 37–42.
35.
ArjunSKarthikSArjunanK, et al.Preparation and evaluation of rosuvastatin calcium nanosuspension and solid dispersion tablets by wet granulation and direct compression techniques using tamarind gum as a binder. Indian J Pharmaceut Sci2020; 82: 32–40.
36.
MaliKKDhawaleSCDiasRJ. Extraction, characterization and functionalization of tamarind gum. Res J Pharm Technol2019; 12: 1745–1752.
37.
DashSMurthyPNNathL, et al.Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm2010; 67: 217–223.
38.
RawoothMHabibullahSKQureshiD, et al.Effect of tamarind gum on the properties of phase-separated poly(vinylalcohol)films. Polymers2022; 14(14): 2793–2817.
39.
KumariSRustagiBMeenaP, et al.Carboxymethyl tamarind kernel gum-based superabsorbent hydrogel for release of copper micronutrient. Int J Biol Macromol2025; 320: 146010.
40.
JanaSSharmaRMaitiS, et al.Interpenetrating hydrogels of O-carboxymethyl tamarind gum and alginate for monitoring delivery of acyclovir. Int J Biol Macromol2016; 92: 1034–1039.
41.
ShawGSUvaneshKGauthamSN, et al.Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study. Des Monomers Polym2015; 18(434): 434–450.
