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Abstract

We compared the sensitivity of diffusion MRI to T2SI for early detection of Wallerian degeneration secondary to cerebral infarction. Serial full tensor DWI of 15 acute stroke patients with B=1221. ROI analysis of ADC, T2, DWI, eigenvalues, and anisotropy indices in bilateral intracerebral corticospinal tracts. 5/16 patients developed DWI hyperintensity and/or ADC/FA reduction, prior to T2 prolongation, during initial two weeks in ipsilateral corticospinal tracts. Mean FA and ADC reductions were 12% and 24% respectively. All were subsequently confirmed to be Wallerian degeneration on follow up MRI.

Another 6/15 patients without observable DWI signal changes demonstrated ipsilateral ADC and FA reductions at one or more levels in CS tracts without subsequent demonstration of Wallerian. Antegrade thalamic transneuronal degeneration was noted in 2/15. Changes in diffusion parameters precede T2 signal abnormalities in the evolution of Wallerian degeneration.

Keywords

ADC diffusion anisotropy cerebral infarction Wallerian degeneration

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References

Lexa

Trojanowski

: The Aging Brain and Neurodegenerative Diseases. In: Atlas

(ed): Magnetic resonance imaging of the brain and spine. Lippincott-Raven, Philadelphia 1996.

Sawlani

Gupta

: MRI demonstration of Wallerian degeneration in various intracranial lesions and its clinical implications. J Neurol Sci 146(2): 103–108, 1997.

Sonoda

Tsubahara

: Extent of pyramidal tract wallerian degeneration in the brain stem on MRI and degree of motor impairment after supratentorial stroke. Disabil Rehabil 14: 89–92, 1992.

Kuhn

Mikulis

: Wallerian degeneration after cerebral infarction: Evaluation with sequential MR imaging. Radiology 172: 179–182, 1989.

Inoue

Matsumura

: MR imaging of Wallerian degeneration in the brainstem: Temporal relationships. Am J Neuroradiol 11: 897–902, 1990.

Duchen

: General pathology of neurons and neuroglia. In: Adams

Duchan

(eds): Greenfiels's neuropathology (5th ed). John Wiley and Sons, New York 1992.

Webster

: The relationship between Schmidt-Lanterman incisures and myelin segmentation during wallerian degeneration. Ann N Y Acad Sci 122: 29–41, 1964.

Nakane

Tamura

: MR detection of secondary changes remote from ischemia: Preliminary observations after occlusion of the middle cerebral artery in rats. Am J Neuroradiol 18: 945–950, 1997.

Sorensen

Buonanno

: Hyperacute stroke evaluation with combined multisection diffusion-weighted and hemodynamically weightedecho-planar MR imaging. Radiology 199: 391–401, 1996.

10.

Basser

Pierpaoli

: Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. JMRI 111: 209–219, 1996.

11.

Basser

Mattiello Le Bihan

: Anisotropic diffusion: MR diffusion tensor imaging. In: Le Bihan

(ed): Diffusion and perfusion magnetic resonance imaging: Applications to functional MRI. Raven Press, New York 1995: 140–149.

12.

Lexa

Grossman

Rosenquist

: MR of wallerian degeneration in the feline visual system: Characterization by magnetization transfer rate with histopathologic correlation. Am J Neuroradiol 15: 201–212, 1994.

ADC and Diffusion Anisotropy Indices in Wallerian Degeneration

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