PET with L-methyl-11C-methionine (Met-PET) is a useful tool for differentiating cerebral tumor from normal brain tissue, but some observations showed a high accumulation of methionine in non-tumorous lesions.
We evaluated whether Met-PET was clinically useful in distinguishing tumor from non-tumor in intracranial lesions. We investigated 50 cases of brain lesions. We had four non-tumorous lesions with an accumulation (false positive) and five tumorous lesions with no accumulation (false negative) in Met-PET. It should be kept in mind that there is a possibility of tumorous or non tumorous lesions in the presence of a low or high accumulation of methionine.
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