We reviewed clinical, laboratory and MR findings in patients with primary Sjögren's syndrome whose initial clinical manifestations were related to CNS involvement. MR is highly sensitive in detecting CNS involvement in this syndrome. Imaging findings are not specific but may offer useful paraclinical information. The etiology of CNS lesions in Sjögren's syndrome is discussed.
AlexanderEL: Neurologic disease in Sjögren's syndrome: Mononuclear inflammatory vasculopathy affecting central/peripheral nervous system and muscle. A clinical review and update of immunopathogenesis. Rheum Dis Clin North AmII: 869–908, 1993.
2.
AlexanderEL: Neurologic Complications of Primary Sjögren's Syndrome. Medicine61(4): 247–257, 1982.
3.
PierotL: Asymptomatic cerebral involvement in Sjögren's syndrome: MRI findings of 15 cases. Neuroradiology35: 378–380, 1993.
4.
AlexanderEL: Anti-Ro(SS-A) autoantibodies in central nervous system disease associated with Sjögren's syndrome (CNS-SS). Clinical, neuroimaging and angiographic correlates. Neurology44: 899–908, 1994.
5.
MolinaR: Two types of inflammatory vascular disease in Sjögren's syndrome. Differential association with serore-activity to rheumatoid factor and antibodies to Ro(SS-A) and with hypocomplementemia. Arthritis and Rheumatism28 (11): 1251–1258, 1985.
6.
SobueG: MRI demonstrates dorsal column involvement of the spinal cord in Sjögren's syndrome-associated neuropathy. Neurology45: 592–593, 1995.
7.
AlexanderEL: Magnetic Resonance Imaging of Cerebral Lesions in Patients with the Sjögren Syndrome. Annals of Internal Medicine108: 815–823, 1988.
