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Abstract

English

Gli angiomi cavernosi sono malformazioni vascolari che possono colpire il SNG. La loro sintomatologia di esordio consiste in crisi convulsive, cefalea, deficit neurologici focali o emorragia.

In letteratura sono stati descritti vari casi familiari e, mediante il loro studio si è potuto affermare che la trasmissione è di tipo genetico, autosomico dominante. Rispetto ai casi sporadici, nelle forme familiari sono inoltre risultate più frequenti le lesioni vascolari multifocali a sede sia intra che extracerebrale.

Le informazioni sulla storia naturale dell'angioma cavernoso sono state raccolte solo in questi ultimi anni, grazie all'introduzione della RM, esame che consente la sicura identificazione e la diagnosi della lesione.

Il nostro studio riguarda una famiglia (madre e due figli) portatrice di angioma cavernoso cerebrale. Tutti e tre i pazienti sono stati sottoposti ad intervento chirurgico e la diagnosi è stata confermata istologicamente.

Considerando la sempre maggior frequenza di casi familiari è auspicabile uno studio, nei casi di angioma cavernoso sporadico, anche sui familiari asintomatici, per una eventuale corretta pianificazione terapeutica e genetica.

Keywords

angioma cavernoso malformazioni vascolari familiari RM

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References

Bicknell

Carlow

: Familial cavernous angiomas. Arch Neurol 35: 746–749, 1978.

Clark

: Familial occurrence of cavernous angiomata of the brain. J Neurol Neurosurg Psychiatry 33: 871–876, 1970.

Corboy

Galetta

: Familial cavernous angiomas manifesting with an acute chiasmal syndrome. Am J Opthalmology 108: 245–250, 1989.

Del Curling

Kelly

: An analysis of the natural history of cavernous angiomas. J Neurosurg 75: 702–708, 1991.

Dobyns

Michels

: Familial cavernous malformations of the central nervous system and retina. Ann Neurol 21: 578, 1987.

Giombini

Morello

: Cavernous angioma of the brain. Account of fourteen personal cases and review of the literature. Acta Neurochir 40: 6182, 1978.

Hayman

Evans

: Familial cavernous angiomas: natural history and genetic study over a 5-year period. Am J Med Genet 11: 147–160, 1982.

Kufs

: Ueber heredofamiliare angiomatose des gehirns und der retina, ihre beziehungen zueinander und zur angiomatose der haunt. Z Neurol Psychiatry 113: 651–686, 1928.

Gomori

Grossman

: Occult cerebral vascular malfomations: high-field MR imaging. Radiology 158: 707–713, 1986.

10.

Jellinger

: Vascular malformations of the central nervous system: a morphological overview. Neurosurg Rev 9: 177–216, 1986.

11.

Liliequist

: Angiography in intracerebral cavernous hemangioma. Neuroradiology 9: 69–72, 1975.

12.

Mason

Aase

: Familal cavernous angiomas of the brain in an Hispanic family. Neurology 38: 324–326, 1988.

13.

McCormik

: Pathology of vascular malformations of the brain. In: Wilson

Stein

, eds. Intracranial arteriovenous malformations. Baltimore: Williams and Wilkins, 1984: 44–63.

14.

Michael

Levin

: Multiple teleangiectases of the brain: discussion of hereditary factors in their development. Arch Nurol Psych 36: 514–529, 1936.

15.

Rigamonti

Drayer

: The MRI appearance of cavernous malformations (angiomas). J Neurosurg 67: 518–524, 1987.

16.

Rigamonti

Hadley

: Cerebral cavernous malformations. Incidence and familial occurence. N Engl J Med 319: 343–347, 1988.

17.

Robinson

Awad

: Natural history of the cavernous angioma. J Neurosurg 75: 709–714, 1991.

18.

Russel

Rubinstein

: Pathology of Tumors of the Nervous System, ed 5. Baltimore: Williams and Wilkins, 1989: 727–765.

19.

Sarwar

McCormik

: Intracerebral venous angioma. Arch Neurol 35: 323–325, 1978.

20.

Savoiardo

: Intracranial cavernous hemangiomas: neuroradiologic review of 36 operated cases. Am J Neuroradiol 4: 945–950, 1983.

21.

Simard

Garcia-Bengochea

: Cavernous angioma: a review of 126 collected and 12 new clinical cases. Neurosurgery 18: 162–172, 1986.

22.

Traverso

Passeri

: A family with hereditary intracerebral cavernous angiomas. Nuova Rivista di Neurologia 612: 71–73, 1991.

23.

Voit

Yasargil

: Cerebral cavernous hemangiomas. Incidence, pathology, localisation, diagnosis, clinical features and treatment. Review of the literature and report of an unusual case. Neurochirurgia 19: 59–68, 1976.

24.

Weber

Vespignani

: Les angiomes caverneux intracerebraux. Rev Neurol 145: 429–436, 1989.

25.

Wilkins

: Natural history of intracranial vascular malformations: a review. Neurosurgery 16: 421–430, 1985.

26.

Wood

White

Kernohan

: Cavernous hemangiomatosis involving the brain, spinal cord, heart, skin and kidney. Proc Mayo Clinic 32: 249–254, 1957.

Angioma Cavernoso Cerebrale

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